دورية أكاديمية
Persistent KSHV Infection Increases EBV-Associated Tumor Formation In Vivo via Enhanced EBV Lytic Gene Expression.
| العنوان: | Persistent KSHV Infection Increases EBV-Associated Tumor Formation In Vivo via Enhanced EBV Lytic Gene Expression. |
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| المؤلفون: | McHugh D; Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland., Caduff N; Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland., Barros MHM; Institute of Pathology, Unfallkrankenhaus Berlin, Berlin, Germany., Rämer PC; Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland., Raykova A; Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland., Murer A; Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland., Landtwing V; Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland., Quast I; Neuroinflammation, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland., Styles CT; Section of Virology, Faculty of Medicine, Imperial College London, London, UK., Spohn M; Virus Genomics, Heinrich Pette Institute, Hamburg, Germany., Fowotade A; School of Biosciences and Medicine, University of Surrey, Guildford, UK., Delecluse HJ; DKFZ unit F100/INSERM unit U1074, Heidelberg, Germany., Papoudou-Bai A; Department of Pathology, Faculty of Medicine, University of Ioannina, Ioannina, Greece., Lee YM; Departments of Pathology and Medical Science, Chungnam National University School of Medicine, Daejeon, Korea., Kim JM; Departments of Pathology and Medical Science, Chungnam National University School of Medicine, Daejeon, Korea., Middeldorp J; Department of Pathology, VU University Medical Center and Cancer Center Amsterdam, Amsterdam, the Netherlands., Schulz TF; Institute of Virology, Hannover Medical School, Hannover and German Centre of Infection Research (DZIF), Hannover-Braunschweig Site, Germany., Cesarman E; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA., Zbinden A; Institute of Medical Virology, University of Zürich, Zürich, Switzerland., Capaul R; Institute of Medical Virology, University of Zürich, Zürich, Switzerland., White RE; Section of Virology, Faculty of Medicine, Imperial College London, London, UK., Allday MJ; Section of Virology, Faculty of Medicine, Imperial College London, London, UK., Niedobitek G; Institute of Pathology, Unfallkrankenhaus Berlin, Berlin, Germany., Blackbourn DJ; School of Biosciences and Medicine, University of Surrey, Guildford, UK., Grundhoff A; Virus Genomics, Heinrich Pette Institute, Hamburg, Germany., Münz C; Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland. Electronic address: muenzc@immunology.uzh.ch. |
| المصدر: | Cell host & microbe [Cell Host Microbe] 2017 Jul 12; Vol. 22 (1), pp. 61-73.e7. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 101302316 Publication Model: Print Cited Medium: Internet ISSN: 1934-6069 (Electronic) Linking ISSN: 19313128 NLM ISO Abbreviation: Cell Host Microbe Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge, Mass. : Cell Press |
| مواضيع طبية MeSH: | Coinfection* , Gene Expression Regulation, Viral*, Herpesvirus 4, Human/*genetics , Herpesvirus 4, Human/*pathogenicity , Herpesvirus 8, Human/*pathogenicity , Herpesvirus 8, Human/*physiology , Neoplasms/*virology, Animals ; B-Lymphocytes/virology ; Cell Line, Tumor ; Cytokines/blood ; DNA, Viral/analysis ; Disease Models, Animal ; Epstein-Barr Virus Infections/blood ; Epstein-Barr Virus Infections/immunology ; Epstein-Barr Virus Infections/virology ; Genes, Viral/genetics ; Herpesviridae Infections/blood ; Herpesviridae Infections/immunology ; Herpesviridae Infections/virology ; Herpesvirus 8, Human/genetics ; High-Throughput Nucleotide Sequencing ; Humans ; Lymphoma, Primary Effusion/etiology ; Lymphoma, Primary Effusion/virology ; Mice ; Spleen/pathology ; Spleen/virology ; Survival Rate ; Virus Replication |
| مستخلص: | The human tumor viruses Epstein-Barr virus (EBV) and Kaposi sarcoma-associated herpesvirus (KSHV) establish persistent infections in B cells. KSHV is linked to primary effusion lymphoma (PEL), and 90% of PELs also contain EBV. Studies on persistent KSHV infection in vivo and the role of EBV co-infection in PEL development have been hampered by the absence of small animal models. We developed mice reconstituted with human immune system components as a model for KSHV infection and find that EBV/KSHV dual infection enhanced KSHV persistence and tumorigenesis. Dual-infected cells displayed a plasma cell-like gene expression pattern similar to PELs. KSHV persisted in EBV-transformed B cells and was associated with lytic EBV gene expression, resulting in increased tumor formation. Evidence of elevated lytic EBV replication was also found in EBV/KSHV dually infected lymphoproliferative disorders in humans. Our data suggest that KSHV augments EBV-associated tumorigenesis via stimulation of lytic EBV replication. (Copyright © 2017 Elsevier Inc. All rights reserved.) |
| معلومات مُعتمدة: | 14-1033 United Kingdom AICR_ Worldwide Cancer Research |
| فهرسة مساهمة: | Keywords: B cell lymphoma; EBV; Epstein-Barr virus; KSHV; Kaposi sarcoma-associated herpesvirus; humanized mouse model; lytic EBV replication; primary effusion lymphoma; virus-associated lymphoma |
| المشرفين على المادة: | 0 (Cytokines) 0 (DNA, Viral) |
| تواريخ الأحداث: | Date Created: 20170714 Date Completed: 20180307 Latest Revision: 20210924 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.chom.2017.06.009 |
| PMID: | 28704654 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1934-6069 |
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| DOI: | 10.1016/j.chom.2017.06.009 |