دورية أكاديمية
أعرض في EDS

Retinal degeneration in progressive supranuclear palsy measured by optical coherence tomography and scanning laser polarimetry.

التفاصيل البيبلوغرافية
العنوان: Retinal degeneration in progressive supranuclear palsy measured by optical coherence tomography and scanning laser polarimetry.
المؤلفون: Stemplewitz B; Department of Ophthalmology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany. b.stemplewitz@asklepios.com., Kromer R; Department of Ophthalmology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany., Vettorazzi E; Department of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany., Hidding U; Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany., Frings A; Department of Ophthalmology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany., Buhmann C; Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany.
المصدر: Scientific reports [Sci Rep] 2017 Jul 13; Vol. 7 (1), pp. 5357. Date of Electronic Publication: 2017 Jul 13.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Scanning Laser Polarimetry* , Tomography, Optical Coherence*, Retinal Degeneration/*diagnostic imaging , Retinal Degeneration/*pathology , Supranuclear Palsy, Progressive/*complications, Aged ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Sensitivity and Specificity
مستخلص: This cross-sectional study compared the retinal morphology between patients with progressive supranuclear palsy (PSP) and healthy controls. (The retinal nerve fiber layer (RNFL) around the optic disc and the retina in the macular area of 22 PSP patients and 151 controls were investigated by spectral domain optical coherence tomography (SD-OCT). Additionally, the RNFL and the nerve fiber index (NFI) were measured by scanning laser polarimetry (SLP). Results of RNFL measurements with SD-OCT and SLP were compared to assess diagnostic discriminatory power. Applying OCT, PSP patients showed a smaller RNFL thickness in the inferior nasal and inferior temporal areas. The macular volume and the thickness of the majority of macular sectors were reduced compared to controls. SLP data showed a thinner RNFL thickness and an increase in the NFI in PSP patients. Sensitivity and specificity to discriminate PSP patients from controls were higher applying SLP than SD-OCT. Retinal changes did not correlate with disease duration or severity in any OCT or SLP measurement. PSP seems to be associated with reduced thickness and volume of the macula and reduction of the RNFL, independent of disease duration or severity. Retinal imaging with SD-OCT and SLP might become an additional tool in PSP diagnosis.
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تواريخ الأحداث: Date Created: 20170715 Date Completed: 20190204 Latest Revision: 20190215
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC5509679
DOI: 10.1038/s41598-017-05575-8
PMID: 28706282
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-017-05575-8