دورية أكاديمية
Nodular lymphocyte predominant Hodgkin's lymphoma in daily practice: A multicenter experience.
| العنوان: | Nodular lymphocyte predominant Hodgkin's lymphoma in daily practice: A multicenter experience. |
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| المؤلفون: | Gemici A; Division of Hematology, Sanliurfa Mehmet AkifInan Training and Research Hospital, Sanliurfa, Turkey., Aydogdu I; Department of Hematology, Celal Bayar University, Manisa, Turkey., Terzi H; Department of Hematology, Cumhuriyet University, Sivas, Turkey., Sencan M; Department of Hematology, Cumhuriyet University, Sivas, Turkey., Aslan A; Department of Medical Oncology, Hacettepe University, Ankara, Turkey., Kaya AH; Hematology and Stem Cell Transplantation Clinic, Ankara Oncology Training and Research Hospital, Ankara, Turkey., Dal MS; Hematology and Stem Cell Transplantation Clinic, Ankara Oncology Training and Research Hospital, Ankara, Turkey., Akay MO; Department of Hematology, Osmangazi University, Eskisehir, Turkey., Dogu MH; Division of Hematology, Istanbul Training and Research Hospital, Istanbul, Turkey., Ayyildiz O; Department of Hematology, Dicle University, Diyarbakir, Turkey., Sahin F; Department of Hematology, Ege University, Izmir, Turkey., Cagliyan GA; Division of Hematology, Denizli State Hospital, Denizli, Turkey., Yilmaz M; Department of Hematology, Gaziantep University, Gaziantep, Turkey., Gokgoz Z; Ordu State Hospital, Division of Hematology, Ordu, Turkey., Bilen Y; Department of Hematology, Ataturk University, Erzurum, Turkey., Demir C; Department of Hematology, YuzuncuYil University, Van, Turkey., Sevindik OG; Department of Hematology, Firat University, Elazig, Turkey., Korkmaz S; Division of Hematology, Kayseri Training and Research Hospital, Kayseri, Turkey., Eser B; Department of Hematology, Erciyes University, Kayseri, Turkey., Altuntas F; Hematology and Stem Cell Transplantation Clinic, Ankara Oncology Training and Research Hospital, Ankara, Turkey. |
| مؤلفون مشاركون: | ThREG, Turkish hematology Research and Education Group |
| المصدر: | Hematological oncology [Hematol Oncol] 2018 Feb; Vol. 36 (1), pp. 116-120. Date of Electronic Publication: 2017 Jul 14. |
| نوع المنشور: | Journal Article; Multicenter Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 8307268 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-1069 (Electronic) Linking ISSN: 02780232 NLM ISO Abbreviation: Hematol Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford, England : Wiley-Blackwell, c1983- |
| مواضيع طبية MeSH: | Hodgkin Disease/*therapy, Adolescent ; Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Young Adult |
| مستخلص: | Nodular lymphocyte predominant Hodgkin's lymphoma (NLPHL) is a rare subtype of Hodgkin's lymphoma. In this study, we aimed to investigate the clinical features and therapeutic outcomes of patients with NLPHL who were diagnosed at different institutes in Turkey. We retrospectively reviewed the records of the patients diagnosed with NLPHL. Adult patients who were diagnosed after 2005 with histological confirmation were selected for the study. Forty-three patients were included in the study. Median age of patients was 37.5 years (18-70) at the time of diagnosis. About 60.5% patients were diagnosed as stage I and II NLPHL, and remaining 39.5% had stage III and IV disease. Median follow-up was 46 months. During follow-up, none of the patients died. Seven patients relapsed or progressed after initial therapy at a median of 12 months. Five of 7 relapsed/refractory patients (71.4%) were salvaged with chemotherapy only (DHAP, ICE), and the remaining 2 (28.6%) were salvaged with chemoimmunotherapy. All of relapsed/refractory patients were able to achieve complete remission after salvage therapy. Lactate dehydrogenase levels were significantly higher in patients with progressive disease compared with nonprogressive disease. Our study showed an excellent outcome with all patients alive at last contact with a median follow up of 46 months despite a wide range of different therapeutic approaches. All relapsed and refractory patients were successfully salvaged despite a low frequency of patients received immunotherapy in conjunction with chemotherapy. Our results suggest that immunotherapy may be reserved for further relapses. (Copyright © 2017 John Wiley & Sons, Ltd.) |
| فهرسة مساهمة: | Keywords: nodular lymphocyte predominant Hodgkin's lymphoma; overall survival; progression-free survival; treatment |
| تواريخ الأحداث: | Date Created: 20170715 Date Completed: 20180305 Latest Revision: 20180305 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1002/hon.2460 |
| PMID: | 28707314 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1099-1069 |
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| DOI: | 10.1002/hon.2460 |