دورية أكاديمية
Metastasis 'systems' biology: how are macro-environmental signals transmitted into microenvironmental cues for disseminated tumor cells?
| العنوان: | Metastasis 'systems' biology: how are macro-environmental signals transmitted into microenvironmental cues for disseminated tumor cells? |
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| المؤلفون: | Grzelak CA; Translational Research Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Ghajar CM; Translational Research Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. Electronic address: cghajar@fredhutch.org. |
| المصدر: | Current opinion in cell biology [Curr Opin Cell Biol] 2017 Oct; Vol. 48, pp. 79-86. Date of Electronic Publication: 2017 Jul 15. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 8913428 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0410 (Electronic) Linking ISSN: 09550674 NLM ISO Abbreviation: Curr Opin Cell Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Elsevier Original Publication: Philadelphia, PA, USA : Current Science, c1988- |
| مواضيع طبية MeSH: | Signal Transduction* , Tumor Microenvironment*, Neoplasm Metastasis/*pathology , Neoplasms/*metabolism , Neoplasms/*pathology, Animals ; Fibrosis/pathology ; Humans ; Liver/metabolism ; Systems Biology ; Wound Healing |
| مستخلص: | Disseminated breast tumor cells reside on or near stable microvascular endothelium. Currently, the cues that disrupt DTC dormancy and facilitate outgrowth are largely unknown. This article explores the hypothesis that specific patient lifestyle exposures (e.g., alcohol abuse) may disrupt the microenvironments that maintain disseminated tumor cell (DTC) dormancy in a tissue-specific fashion. We suggest that such exposures are 'transmitted' to the dormant niche in the form of injury. Thus, we discuss the relationship between wound healing and metastasis using liver as an example to illustrate how injury steers the phenotype of liver endothelium and perivascular hepatic stellate cells to a potentially pro-metastatic one. We posit further that non-steroidal anti-inflammatory drugs (NSAIDs) - recently shown to prevent metastatic relapse - may act by preserving the dormant niche. We conclude by suggesting that maintenance of the dormant niche - either through patient lifestyle or via development of therapeutics that mimic local molecular cues/responses that coincide with a healthy lifestyle - is a means to prevent metastatic relapse, and should be the subject of far greater research. (Copyright © 2017 Elsevier Ltd. All rights reserved.) |
| تواريخ الأحداث: | Date Created: 20170718 Date Completed: 20171226 Latest Revision: 20181202 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.ceb.2017.06.002 |
| PMID: | 28715713 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1879-0410 |
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| DOI: | 10.1016/j.ceb.2017.06.002 |