دورية أكاديمية
أعرض في EDS

Let-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice.

التفاصيل البيبلوغرافية
العنوان: Let-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice.
المؤلفون: Jiang X; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, 94143, USA., Hawkins JS; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, 94143, USA., Lee J; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, 94143, USA., Lizama CO; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, 94143, USA., Bos FL; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, 94143, USA., Zape JP; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, 94143, USA., Ghatpande P; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, 94143, USA., Peng Y; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, 94143, USA., Louie J; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, 94143, USA., Lagna G; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, 94143, USA., Zovein AC; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, 94143, USA.; Department of Pediatrics, Division of Neonatology, University of California San Francisco School of Medicine, San Francisco, CA, 94143, USA., Hata A; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, 94143, USA. akiko.hata@ucsf.edu.
المصدر: Nature communications [Nat Commun] 2017 Jul 25; Vol. 8 (1), pp. 128. Date of Electronic Publication: 2017 Jul 25.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: Hematopoiesis/*genetics , Hematopoietic Stem Cells/*metabolism , Leukotriene B4/*metabolism , MicroRNAs/*genetics , Stem Cell Niche/*genetics, Animals ; Aorta/metabolism ; Endothelium, Vascular/metabolism ; Liver/embryology ; Liver/metabolism ; Mice, 129 Strain ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Microscopy, Fluorescence ; Reverse Transcriptase Polymerase Chain Reaction ; Ribonuclease III/genetics ; Ribonuclease III/metabolism ; Signal Transduction/genetics
مستخلص: Hematopoietic stem and progenitor cells arise from the vascular endothelium of the dorsal aorta and subsequently switch niche to the fetal liver through unknown mechanisms. Here we report that vascular endothelium-specific deletion of mouse Drosha (Drosha cKO ), an enzyme essential for microRNA biogenesis, leads to anemia and death. A similar number of hematopoietic stem and progenitor cells emerge from Drosha-deficient and control vascular endothelium, but Drosha cKO -derived hematopoietic stem and progenitor cells accumulate in the dorsal aorta and fail to colonize the fetal liver. Depletion of the let-7 family of microRNAs is a primary cause of this defect, as it leads to activation of leukotriene B4 signaling and induction of the α4β1 integrin cell adhesion complex in hematopoietic stem and progenitor cells. Inhibition of leukotriene B4 or integrin rescues maturation and migration of Drosha cKO hematopoietic stem and progenitor cells to the fetal liver, while it hampers hematopoiesis in wild-type animals. Our study uncovers a previously undefined role of innate leukotriene B4 signaling as a gatekeeper of the hematopoietic niche transition.Hematopoietic stem and progenitor cells are generated first from the vascular endothelium of the dorsal aorta and then the fetal liver but what regulates this switch is unknown. Here, the authors show that changing miRNA biogenesis and leukotriene B4 signaling in mice modulates this switch in the niche.
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معلومات مُعتمدة: T32 GM008284 United States GM NIGMS NIH HHS; R01 HL093154 United States HL NHLBI NIH HHS; R01 HL116191 United States HL NHLBI NIH HHS; T32 HL007731 United States HL NHLBI NIH HHS; T32 GM008568 United States GM NIGMS NIH HHS; R01 HL108317 United States HL NHLBI NIH HHS; DP2 HL117743 United States HL NHLBI NIH HHS; United Kingdom Wellcome Trust
المشرفين على المادة: 0 (MicroRNAs)
0 (mirnlet7 microRNA, mouse)
1HGW4DR56D (Leukotriene B4)
EC 3.1.26.3 (Drosha protein, mouse)
EC 3.1.26.3 (Ribonuclease III)
تواريخ الأحداث: Date Created: 20170727 Date Completed: 20171117 Latest Revision: 20220317
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC5527007
DOI: 10.1038/s41467-017-00137-y
PMID: 28743859
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/s41467-017-00137-y