دورية أكاديمية
Regulatory T-Cell Distribution within Lung Compartments in COPD.
| العنوان: | Regulatory T-Cell Distribution within Lung Compartments in COPD. |
|---|---|
| المؤلفون: | Sales DS; a Department of Medicine, Laboratory of Experimental Therapeutics (LIM-20), School of Medicine , University of Sao Paulo , Sao Paulo , Brazil., Ito JT; a Department of Medicine, Laboratory of Experimental Therapeutics (LIM-20), School of Medicine , University of Sao Paulo , Sao Paulo , Brazil., Zanchetta IA; a Department of Medicine, Laboratory of Experimental Therapeutics (LIM-20), School of Medicine , University of Sao Paulo , Sao Paulo , Brazil., Annoni R; b Department of Pathology, School of Medicine , University of Sao Paulo , Sao Paulo , Brazil., Aun MV; c Clinical Immunology and Allergy Division, School of Medicine , University of Sao Paulo , Sao Paulo , Brazil., Ferraz LFS; b Department of Pathology, School of Medicine , University of Sao Paulo , Sao Paulo , Brazil., Cervilha DAB; a Department of Medicine, Laboratory of Experimental Therapeutics (LIM-20), School of Medicine , University of Sao Paulo , Sao Paulo , Brazil., Negri E; d Department of Medicine, Laboratory of Cell Biology (LIM-59), School of Medicine , University of Sao Paulo , Sao Paulo , Brazil., Mauad T; b Department of Pathology, School of Medicine , University of Sao Paulo , Sao Paulo , Brazil., Martins MA; a Department of Medicine, Laboratory of Experimental Therapeutics (LIM-20), School of Medicine , University of Sao Paulo , Sao Paulo , Brazil., Lopes FDTQS; a Department of Medicine, Laboratory of Experimental Therapeutics (LIM-20), School of Medicine , University of Sao Paulo , Sao Paulo , Brazil. |
| المصدر: | COPD [COPD] 2017 Oct; Vol. 14 (5), pp. 533-542. Date of Electronic Publication: 2017 Jul 26. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 101211769 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1541-2563 (Electronic) Linking ISSN: 15412563 NLM ISO Abbreviation: COPD Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: Monticello, NY : Marcel Dekker, c2004- |
| مواضيع طبية MeSH: | Lung/*immunology , Lymphoid Tissue/*immunology , Pulmonary Disease, Chronic Obstructive/*immunology , Smoking/*immunology , T-Lymphocytes, Regulatory/*immunology, Adaptive Immunity ; Adult ; Aged ; B-Cell Activating Factor/metabolism ; B-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Female ; Forced Expiratory Volume ; Humans ; Interleukin-10/metabolism ; Interleukin-17/metabolism ; Lymphocyte Count ; Male ; Middle Aged ; Pulmonary Disease, Chronic Obstructive/pathology ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Smoking/pathology ; Smoking/physiopathology ; T-Lymphocytes, Regulatory/metabolism ; Transforming Growth Factor beta/metabolism ; Vital Capacity |
| مستخلص: | The importance of the adaptive immune response, specifically the role of regulatory T (Treg) cells in controlling the obstruction progression in smokers, has been highlighted. To quantify the adaptive immune cells in different lung compartments, we used lung tissues from 21 never-smokers without lung disease, 22 current and/or ex-smokers without lung disease (NOS) and 13 current and/or ex-smokers with chronic obstructive pulmonary disease (COPD) for histological analysis. We observed increased T, B, IL-17 and BAFF + cells in small and large airways of COPD individuals; however, in the NOS, we only observed increase in T and IL-17 + cells only in small airways. A decrease in the density of Treg + , TGF-β + and IL-10 + in small and large airways was observed only in COPD individuals. In the lymphoid tissues, Treg, T,B-cells and BAFF + cells were also increased in COPD; however, changes in Treg inhibitory associated cytokines were not observed in this compartment. Therefore, our results suggest that difference in Treg + cell distributions in lung compartments and the decrease in TGF-β + and IL-10 + cells in the airways may lead to the obstruction in smokers. |
| فهرسة مساهمة: | Keywords: Adaptive immunity; COPD; T-cells; TGF-β; interleukin-10; regulatory T-cells |
| المشرفين على المادة: | 0 (B-Cell Activating Factor) 0 (Interleukin-17) 0 (TNFSF13B protein, human) 0 (Transforming Growth Factor beta) 130068-27-8 (Interleukin-10) |
| تواريخ الأحداث: | Date Created: 20170727 Date Completed: 20180712 Latest Revision: 20180712 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1080/15412555.2017.1346069 |
| PMID: | 28745532 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1541-2563 |
|---|---|
| DOI: | 10.1080/15412555.2017.1346069 |