دورية أكاديمية
FETAX Assay for Evaluation of Developmental Toxicity.
| العنوان: | FETAX Assay for Evaluation of Developmental Toxicity. |
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| المؤلفون: | Mouche I; GenEvolutioN, 4, Rue des frères Montgolfier, Rosny-sur-Seine, 78710, France. isabelle.mouche@genevolution.fr., Malésic L; Paris, France., Gillardeaux O; Paris, France. |
| المصدر: | Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2017; Vol. 1641, pp. 311-324. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029 (Electronic) Linking ISSN: 10643745 NLM ISO Abbreviation: Methods Mol Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Totowa, NJ : Humana Press Original Publication: Clifton, N.J. : Humana Press, |
| مواضيع طبية MeSH: | Biological Assay/*methods , Toxicity Tests/*methods, Animals ; Embryo, Nonmammalian/drug effects ; Larva/drug effects ; Larva/metabolism ; Teratogens/toxicity ; Xenopus laevis/embryology |
| مستخلص: | The frog embryo teratogenesis assay Xenopus (FETAX) test is a development toxicity screening test. Due to the small amount of compound needed and the capability to study organogenesis in a short period of time (96 h), FETAX test constitutes an efficient development toxicity alert test when performed early in drug safety development. The test is conducted on fertilized Xenopus laevis mid-blastula-stage eggs over the organogenesis period. Compound teratogenic potential is determined after analysis of the mortality and malformation observations on larvae. In parallel, FETAX test provides also information concerning embryotoxic effect based on larva length. |
| فهرسة مساهمة: | Keywords: Development; Embryo; FETAX; Teratogen; Teratogenesis; Toxicity; Xenopus laevis |
| المشرفين على المادة: | 0 (Teratogens) |
| تواريخ الأحداث: | Date Created: 20170728 Date Completed: 20180417 Latest Revision: 20180719 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1007/978-1-4939-7172-5_17 |
| PMID: | 28748472 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1940-6029 |
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| DOI: | 10.1007/978-1-4939-7172-5_17 |