دورية أكاديمية
Evidence of bone marrow downregulation in brain-dead rats.
| العنوان: | Evidence of bone marrow downregulation in brain-dead rats. |
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| المؤلفون: | Menegat L; Heart Institute (InCor), LIM 11, University of São Paulo Medical School, São Paulo, SP, Brazil., Simas R; Heart Institute (InCor), LIM 11, University of São Paulo Medical School, São Paulo, SP, Brazil., Caliman JM; Heart Institute (InCor), LIM 11, University of São Paulo Medical School, São Paulo, SP, Brazil., Zanoni FL; Heart Institute (InCor), LIM 11, University of São Paulo Medical School, São Paulo, SP, Brazil., Jacysyn JF; LIM 62, University of São Paulo Medical School, São Paulo, SP, Brazil., da Silva LFF; Department of Pathology, University of São Paulo Medical School, São Paulo, SP, Brazil., Borelli P; Faculty of Pharmaceutical Sciences, Department of Clinical and Toxicological Analyses, University of São Paulo, São Paulo, SP, Brazil., Moreira LFP; Heart Institute (InCor), LIM 11, University of São Paulo Medical School, São Paulo, SP, Brazil., Sannomiya P; Heart Institute (InCor), LIM 11, University of São Paulo Medical School, São Paulo, SP, Brazil. |
| المصدر: | International journal of experimental pathology [Int J Exp Pathol] 2017 Jun; Vol. 98 (3), pp. 158-165. Date of Electronic Publication: 2017 Jul 27. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley Country of Publication: England NLM ID: 9014042 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2613 (Electronic) Linking ISSN: 09599673 NLM ISO Abbreviation: Int J Exp Pathol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford, OX : Wiley, c1990- |
| مواضيع طبية MeSH: | Bone Marrow Cells/*pathology , Brain Death/*pathology, Animals ; Apoptosis ; Bone Marrow Cells/immunology ; Bone Marrow Cells/metabolism ; Brain Death/immunology ; Brain Death/metabolism ; Cell Adhesion Molecules/metabolism ; Disease Models, Animal ; Down-Regulation ; Granulocytes/metabolism ; Hemodynamics/physiology ; Leukocyte Count ; Leukopenia/etiology ; Lymphocyte Subsets/immunology ; Male ; Necrosis ; Rats, Wistar |
| مستخلص: | Experimental findings support the evidence of a persistent leucopenia triggered by brain death (BD). This study aimed to investigate leucocyte behaviour in bone marrow and blood after BD in rats. BD was induced using intracranial balloon catheter inflation. Sham-operated (SH) rats were trepanned only. Thereafter bone marrow cells were harvested every six hours from the femoral cavity and used for total and differential counts. They were analysed further by flow cytometry to characterize lymphocyte subsets, granulocyte adhesion molecules expression and apoptosis/necrosis [annexin V/propidium iodide (PI) protocol]. BD rats exhibited a reduction in bone marrow cells due to a reduction in lymphocytes (40%) and segmented cells (45%). Bone marrow lymphocyte subsets were similar in BD and SH rats (CD3, P = 0.1; CD4, P = 0.4; CD3/CD4, P = 0.4; CD5, P = 0.4, CD3/CD5, P = 0.2; CD8, P = 0.8). Expression of L-selectin and beta (© 2017 The Authors. International Journal of Experimental Pathology © 2017 International Journal of Experimental Pathology.) |
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| فهرسة مساهمة: | Keywords: bone marrow downregulation; brain death; rats |
| المشرفين على المادة: | 0 (Cell Adhesion Molecules) |
| تواريخ الأحداث: | Date Created: 20170728 Date Completed: 20170918 Latest Revision: 20181113 |
| رمز التحديث: | 20240829 |
| مُعرف محوري في PubMed: | PMC5573774 |
| DOI: | 10.1111/iep.12234 |
| PMID: | 28749083 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1365-2613 |
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| DOI: | 10.1111/iep.12234 |