دورية أكاديمية
أعرض في EDS

Determination of the residue levels of nicarbazin and combination nicarbazin-narasin in broiler chickens after oral administration.

التفاصيل البيبلوغرافية
العنوان: Determination of the residue levels of nicarbazin and combination nicarbazin-narasin in broiler chickens after oral administration.
المؤلفون: Lima AL; Departamento de Tecnologia e Inspeção de Produtos de Origem Animal, Escola de Veterinária, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil., Barreto F; Laboratório Nacional Agropecuário (LANAGRO-RS), Ministério da Agricultura, Pecuária e Abastecimento, Porto Alegre, Rio Grande do Sul, Brazil., Rau RB; Laboratório Nacional Agropecuário (LANAGRO-RS), Ministério da Agricultura, Pecuária e Abastecimento, Porto Alegre, Rio Grande do Sul, Brazil., Silva GRD; Departamento de Tecnologia e Inspeção de Produtos de Origem Animal, Escola de Veterinária, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil., Lara LJC; Departamento de Tecnologia e Inspeção de Produtos de Origem Animal, Escola de Veterinária, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil., Figueiredo TC; Departamento de Tecnologia e Inspeção de Produtos de Origem Animal, Escola de Veterinária, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil., Assis DCS; Departamento de Tecnologia e Inspeção de Produtos de Origem Animal, Escola de Veterinária, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil., Cançado SV; Departamento de Tecnologia e Inspeção de Produtos de Origem Animal, Escola de Veterinária, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
المصدر: PloS one [PLoS One] 2017 Jul 27; Vol. 12 (7), pp. e0181755. Date of Electronic Publication: 2017 Jul 27 (Print Publication: 2017).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Coccidiostats/*pharmacokinetics , Nicarbazin/*pharmacokinetics , Pyrans/*pharmacokinetics, Administration, Oral ; Animals ; Chickens ; Coccidiostats/administration & dosage ; Drug Combinations ; Drug Residues ; Food Safety ; Nicarbazin/administration & dosage ; Pyrans/administration & dosage
مستخلص: The depletion times of the anticoccidial nicarbazin administered individually and of nicarbazin and narasin administered in combination were evaluated by determining the presence and levels of 4,4'-dinitrocarbanilide (DNC), the marker residue for nicarbazin, and narasin residues in the muscle tissues of broiler chickens subjected to a pharmacological treatment. A high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was used. The results showed the presence of all anticoccidial residues; however, the DNC levels were higher when the nicarbazin was administered individually than when it was used in association with narasin throughout the experimental period. After six days of withdrawal, the DNC level following nicarbazin administration alone was lower than the maximum residue level (MRL) of 200 μg kg-1. However, when the nicarbazin was co-administered with narasin, the concentrations of DNC were lower than the MRL after four days of withdrawal. These results may be justified because the dosage of nicarbazin, when administrated individually, is greater than when it is used in combination with narasin. The levels of narasin were lower than the MRL of 15 μg kg-1 throughout the evaluation period. It was concluded that nicarbazin is rapidly metabolized from the broiler muscles up to six days of withdrawal since the DNC levels were lower than the maximum residue level (MRL) and the concentrations of narasin were lower than the MRL throughout the evaluation period.
References: Food Addit Contam. 2000 Dec;17(12):1001-6. (PMID: 11271833)
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2008 Jan;25(1):32-40. (PMID: 17957540)
J Vet Pharmacol Ther. 2009 Oct;32(5):451-6. (PMID: 19754911)
Food Addit Contam. 1995 Jan-Feb;12(1):93-9. (PMID: 7758637)
J Chromatogr A. 2012 Aug 31;1253:94-104. (PMID: 22819368)
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2013;30(6):958-69. (PMID: 23731083)
Poult Sci. 1995 Mar;74(3):577-80. (PMID: 7761342)
J Microbiol Methods. 2001 Mar 1;44(2):131-7. (PMID: 11165342)
Poult Sci. 1989 Mar;68(3):428-34. (PMID: 2704700)
Food Addit Contam. 2007 Sep;24(9):923-34. (PMID: 17691005)
Talanta. 2017 Jun 1;168:43-51. (PMID: 28391864)
Anal Chim Acta. 2011 Aug 26;700(1-2):26-33. (PMID: 21742113)
Food Addit Contam. 2003 Feb;20(2):136-40. (PMID: 12623661)
J Vet Pharmacol Ther. 2011 Dec;34(6):521-56. (PMID: 21679196)
المشرفين على المادة: 0 (Coccidiostats)
0 (Drug Combinations)
0 (Pyrans)
11P9NUA12U (Nicarbazin)
DZY9VU539P (narasin)
تواريخ الأحداث: Date Created: 20170728 Date Completed: 20170928 Latest Revision: 20181113
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC5531545
DOI: 10.1371/journal.pone.0181755
PMID: 28750013
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0181755