دورية أكاديمية
Prevalence, risk factors, and antimalarial resistance patterns of falciparum plasmodiasis among pregnant women in Kaduna metropolis, Nigeria.
| العنوان: | Prevalence, risk factors, and antimalarial resistance patterns of falciparum plasmodiasis among pregnant women in Kaduna metropolis, Nigeria. |
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| المؤلفون: | Aliyu MM; Department of Biological Science, National Defense Academy, Kaduna State, Nigeria., Nasir IA; Department of Medical Laboratory Services, University of Abuja Teaching Hospital, Gwagwalada, Federal Capital Territory, Abuja, Nigeria., Umar YA; Department of Biological Science, National Defense Academy, Kaduna State, Nigeria., Vanstawa AP; Department of Biological Science, National Defense Academy, Kaduna State, Nigeria., Medugu JT; Department of Medical Laboratory Science, University of Maiduguri, Borno State, Nigeria., Emeribe AU; Department of Medical Laboratory Science, University of Calabar, Cross River State, Nigeria., Amadu DO; Department of Medical Microbiology and Parasitology, University of Ilorin Teaching Hospital, Ilorin, Nigeria. |
| المصدر: | Ci ji yi xue za zhi = Tzu-chi medical journal [Ci Ji Yi Xue Za Zhi] 2017 Apr-Jun; Vol. 29 (2), pp. 98-103. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Buddhist Compassion Relief Tzu Chi Foundation Country of Publication: China (Republic : 1949- ) NLM ID: 9514171 Publication Model: Print Cited Medium: Print NLM ISO Abbreviation: Ci Ji Yi Xue Za Zhi Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: Hualien : Buddhist Compassion Relief Tzu Chi Foundation Original Publication: Hualian Xian [Taiwan] : Fo jiao ci ji ci shan shi ye ji jin hui, Min'guo 78 [1989]- |
| مستخلص: | Objective: Pregnant women infected with malaria represent a significant obstetric problem, especially in the face of antimalarial resistance. This cross-sectional study investigated the prevalence of malaria parasitemia, associated risk factors as well as the antimalarial resistance pattern of Plasmodium isolates from pregnant women attending four selected secondary health facilities in Kaduna State, Nigeria. Materials and Methods: Blood samples were collected from 353 pregnant women attending selected hospitals. Malaria microscopy and parasite density count were conducted based on standard protocols. Antimalarial susceptibility test (using chloroquine, artesunate, artether, and sulfadoxine-pyrimethamine), and hemoglobin concentrations were determined using schizont maturation assay and methemoglobin method, respectively. Multiple-drug resistance (MDR) was defined by resistance against ≥3 antimalarial drugs. Results: The overall prevalence of plasmodiasis was 22.4%. Out of those infected, 5.2% was found to be anemic. Malaria parasitemia was significantly associated with parity, residential area, age of women, and use of preventive measures against malaria ( P < 0.05) but not with hemoglobin concentration, occupation, and trimester of pregnancy ( P > 0.05). Malaria parasites from the pregnant women exhibited the highest resistance against chloroquine, 75 (94.9%) followed Artemether, 30 (37.9%) then sulfadoxine-pyrimethamine, 29 (36.7%) and least resistant to artesunate, 28 (35.4%). The prevalence of MDR was 40.5% (32/79). Conclusion: The prevalence of malaria was relatively high due to inadequate and/or ineffective preventive measures adopted by pregnant women. More so, significant isolates of Plasmodium falciparum exhibited MDR against antimalarial agents tested. Competing Interests: There are no conflicts of interest. |
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| فهرسة مساهمة: | Keywords: Anemia; Antimalaria; Coinfection; Preventive measures |
| تواريخ الأحداث: | Date Created: 20170801 Latest Revision: 20191120 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC5509200 |
| DOI: | 10.4103/tcmj.tcmj_22_17 |
| PMID: | 28757774 |
| قاعدة البيانات: | MEDLINE |
| DOI: | 10.4103/tcmj.tcmj_22_17 |
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