Correlation between HPV status at T and N sites of oropharyngeal squamous cell carcinomas.

التفاصيل البيبلوغرافية
العنوان:	Correlation between HPV status at T and N sites of oropharyngeal squamous cell carcinomas.
المؤلفون:	Josiassen MV; a Department of Otorhinolaryngology, Head and Neck Surgery and Audiology , Rigshospitalet, University of Copenhagen , Copenhagen , Denmark., Charabi B; a Department of Otorhinolaryngology, Head and Neck Surgery and Audiology , Rigshospitalet, University of Copenhagen , Copenhagen , Denmark., Lajer CB; a Department of Otorhinolaryngology, Head and Neck Surgery and Audiology , Rigshospitalet, University of Copenhagen , Copenhagen , Denmark., Garnaes E; a Department of Otorhinolaryngology, Head and Neck Surgery and Audiology , Rigshospitalet, University of Copenhagen , Copenhagen , Denmark., Hamilton Therkildsen M; b Department of Pathology , Rigshospitalet, University of Copenhagen , Copenhagen , Denmark., Norrild B; c Department of Cellular and Molecular Medicine , Rigshospitalet, University of Copenhagen , Copenhagen , Denmark., Specht L; d Department of Oncology , Rigshospitalet, University of Copenhagen , Copenhagen , Denmark., Nielsen FC; e Genomic Medicine, Rigshospitalet , University of Copenhagen , Copenhagen , Denmark., von Buchwald C; a Department of Otorhinolaryngology, Head and Neck Surgery and Audiology , Rigshospitalet, University of Copenhagen , Copenhagen , Denmark.
المصدر:	Acta oto-laryngologica [Acta Otolaryngol] 2017 Dec; Vol. 137 (12), pp. 1260-1264. Date of Electronic Publication: 2017 Jul 30.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Taylor & Francis Country of Publication: England NLM ID: 0370354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1651-2251 (Electronic) Linking ISSN: 00016489 NLM ISO Abbreviation: Acta Otolaryngol Subsets: MEDLINE
أسماء مطبوعة:	Publication: 2015- : Abingdon, Oxford : Taylor & Francis Original Publication: Stockholm : Scandinavian University Press
مواضيع طبية MeSH:	Genes, p16, Carcinoma, Squamous Cell/virology , Human papillomavirus 16/isolation & purification , Oropharyngeal Neoplasms/virology, Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/pathology ; Humans ; Lymphatic Metastasis ; Neck/pathology ; Oropharyngeal Neoplasms/genetics ; Oropharyngeal Neoplasms/pathology
مستخلص:	Objectives: Human papilloma virus (HPV) is known to be associated with oropharyngeal squamous cell carcinomas (OPSCC) and may potentially play a vital role in tumor metastasis. The purpose of this study was to correlate HPV status of cervical lymph node metastases with their respective primary OPSCC tumor. Methods: Formalin-fixed, paraffin-embedded (FFPE) tissue samples obtained from 34 patients with cervical lymph node metastases were analyzed with HPV 16 DNA polymerase chain reaction (PCR), p16 immunohistochemistry and HPV typing. The results were correlated with the HPV status and type found in the primary tumors of OPSCC. Results: Comparing HPV DNA status with p16 we found that 21 primary tumors and lymph node metastases were HPV positive (61.8%) and seven primary tumors and lymph node metastases were HPV negative (20.6%). Six patient samples differed when correlating the primary tumor and lymph node metastasis (17.6%). Conclusions: In this study, HPV status in OPSCCs and their cervical lymph node metastases correlated in the vast majority of cases. However, HPV detection methods may have certain limitations resulting in varying degree of non-correlation. This should be taken into account when stratifying treatment in regard to HPV status.
فهرسة مساهمة:	Keywords: HPV; cervical lymph node metastases; oropharyngeal cancer; p16; squamous cell carcinoma
تواريخ الأحداث:	Date Created: 20170801 Date Completed: 20180604 Latest Revision: 20180604
رمز التحديث:	20240628
DOI:	10.1080/00016489.2017.1356934
PMID:	28758552
قاعدة البيانات:	MEDLINE

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الوصف
تدمد:	1651-2251
DOI:	10.1080/00016489.2017.1356934