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Mitochondria-Targeted Antioxidant SkQ1 Improves Dermal Wound Healing in Genetically Diabetic Mice.

التفاصيل البيبلوغرافية
العنوان: Mitochondria-Targeted Antioxidant SkQ1 Improves Dermal Wound Healing in Genetically Diabetic Mice.
المؤلفون: Demyanenko IA; Faculty of Biology, Lomonosov Moscow State University, Leninskie Gory 1-12, Moscow 119234, Russia., Zakharova VV; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Leninskie Gory 1-40, Moscow 119992, Russia., Ilyinskaya OP; Faculty of Biology, Lomonosov Moscow State University, Leninskie Gory 1-12, Moscow 119234, Russia., Vasilieva TV; Faculty of Biology, Lomonosov Moscow State University, Leninskie Gory 1-12, Moscow 119234, Russia., Fedorov AV; Faculty of Biology, Lomonosov Moscow State University, Leninskie Gory 1-12, Moscow 119234, Russia., Manskikh VN; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Leninskie Gory 1-40, Moscow 119992, Russia.; Institute of Mitoengineering, Lomonosov Moscow State University, Leninskie Gory 1-73, Moscow 119992, Russia., Zinovkin RA; Faculty of Biology, Lomonosov Moscow State University, Leninskie Gory 1-12, Moscow 119234, Russia.; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Leninskie Gory 1-40, Moscow 119992, Russia.; Institute of Mitoengineering, Lomonosov Moscow State University, Leninskie Gory 1-73, Moscow 119992, Russia., Pletjushkina OY; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Leninskie Gory 1-40, Moscow 119992, Russia., Chernyak BV; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Leninskie Gory 1-40, Moscow 119992, Russia., Skulachev VP; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Leninskie Gory 1-40, Moscow 119992, Russia.; Institute of Mitoengineering, Lomonosov Moscow State University, Leninskie Gory 1-73, Moscow 119992, Russia., Popova EN; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Leninskie Gory 1-40, Moscow 119992, Russia.
المصدر: Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2017; Vol. 2017, pp. 6408278. Date of Electronic Publication: 2017 Jul 06.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 101479826 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1942-0994 (Electronic) Linking ISSN: 19420994 NLM ISO Abbreviation: Oxid Med Cell Longev Subsets: MEDLINE
أسماء مطبوعة: Publication: 2011- : New York : Hindawi Pub. Corp.
Original Publication: 2008-2010: Austin, TX : Landes Bioscience
مواضيع طبية MeSH: Dermis/*metabolism , Diabetes Mellitus, Experimental/*drug therapy , Diabetes Mellitus, Type 2/*drug therapy , Mitochondria/*metabolism , Plastoquinone/*analogs & derivatives , Wound Healing/*drug effects, Animals ; Dermis/pathology ; Diabetes Mellitus, Experimental/genetics ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Experimental/pathology ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Type 2/pathology ; Mice ; Mice, Knockout ; Mitochondria/genetics ; Oxidative Stress/drug effects ; Plastoquinone/pharmacology
مستخلص: Oxidative stress is widely recognized as an important factor in the delayed wound healing in diabetes. However, the role of mitochondrial reactive oxygen species in this process is unknown. It was assumed that mitochondrial reactive oxygen species are involved in many wound-healing processes in both diabetic humans and animals. We have applied the mitochondria-targeted antioxidant 10-(6'-plastoquinonyl)decyltriphenylphosphonium (SkQ1) to explore the role of mitochondrial reactive oxygen species in the wound healing of genetically diabetic mice. Healing of full-thickness excisional dermal wounds in diabetic C57BL/KsJ-db - /db - mice was significantly enhanced after long-term (12 weeks) administration of SkQ1. SkQ1 accelerated wound closure and stimulated epithelization, granulation tissue formation, and vascularization. On the 7th day after wounding, SkQ1 treatment increased the number of α -smooth muscle actin-positive cells (myofibroblasts), reduced the number of neutrophils, and increased macrophage infiltration. SkQ1 lowered lipid peroxidation level but did not change the level of the circulatory IL-6 and TNF. SkQ1 pretreatment also stimulated cell migration in a scratch-wound assay in vitro under hyperglycemic condition. Thus, a mitochondria-targeted antioxidant normalized both inflammatory and regenerative phases of wound healing in diabetic mice. Our results pointed to nearly all the major steps of wound healing as the target of excessive mitochondrial reactive oxygen species production in type II diabetes.
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المشرفين على المادة: 0 (10-(6'-plastoquinonyl)decyltriphenylphosphonium)
OAC30J69CN (Plastoquinone)
تواريخ الأحداث: Date Created: 20170802 Date Completed: 20180417 Latest Revision: 20181113
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC5518517
DOI: 10.1155/2017/6408278
PMID: 28761623
قاعدة البيانات: MEDLINE
الوصف
تدمد:1942-0994
DOI:10.1155/2017/6408278