دورية أكاديمية
Mitochondrial Superoxide Increases Age-Associated Susceptibility of Human Dermal Fibroblasts to Radiation and Chemotherapy.
العنوان: | Mitochondrial Superoxide Increases Age-Associated Susceptibility of Human Dermal Fibroblasts to Radiation and Chemotherapy. |
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المؤلفون: | Mapuskar KA; Department of Radiation Oncology, The University of Iowa, Iowa City, Iowa., Flippo KH; Department of Pharmacology, The University of Iowa, Iowa City, Iowa., Schoenfeld JD; Department of Radiation Oncology, The University of Iowa, Iowa City, Iowa., Riley DP; Galera Therapeutics, Inc., Malvern, Pennsylvania., Strack S; Department of Pharmacology, The University of Iowa, Iowa City, Iowa., Hejleh TA; Department of Internal Medicine, The University of Iowa, Iowa City, Iowa., Furqan M; Department of Internal Medicine, The University of Iowa, Iowa City, Iowa., Monga V; Department of Internal Medicine, The University of Iowa, Iowa City, Iowa., Domann FE; Department of Radiation Oncology, The University of Iowa, Iowa City, Iowa., Buatti JM; Department of Radiation Oncology, The University of Iowa, Iowa City, Iowa., Goswami PC; Department of Radiation Oncology, The University of Iowa, Iowa City, Iowa., Spitz DR; Department of Radiation Oncology, The University of Iowa, Iowa City, Iowa., Allen BG; Department of Radiation Oncology, The University of Iowa, Iowa City, Iowa. bryan-allen@uiowa.edu. |
المصدر: | Cancer research [Cancer Res] 2017 Sep 15; Vol. 77 (18), pp. 5054-5067. Date of Electronic Publication: 2017 Aug 01. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Baltimore, Md. : American Association for Cancer Research Original Publication: Chicago [etc.] |
مواضيع طبية MeSH: | Radiation, Ionizing*, Cisplatin/*adverse effects , Fibroblasts/*pathology , Mitochondria/*pathology , Skin/*pathology , Superoxides/*metabolism, Adult ; Age Factors ; Aged ; Animals ; Antineoplastic Agents/adverse effects ; Apoptosis/drug effects ; Apoptosis/radiation effects ; Cell Proliferation/drug effects ; Cell Proliferation/radiation effects ; Cells, Cultured ; Fibroblasts/drug effects ; Fibroblasts/radiation effects ; Humans ; Male ; Membrane Potential, Mitochondrial/drug effects ; Membrane Potential, Mitochondrial/radiation effects ; Mice ; Mice, Inbred C57BL ; Mitochondria/drug effects ; Mitochondria/radiation effects ; Oxidative Stress ; Skin/drug effects ; Skin/radiation effects ; Superoxide Dismutase/metabolism ; Young Adult |
مستخلص: | Elderly cancer patients treated with ionizing radiation (IR) or chemotherapy experience more frequent and greater normal tissue toxicity relative to younger patients. The current study demonstrates that exponentially growing fibroblasts from elderly (old) male donor subjects (70, 72, and 78 years) are significantly more sensitive to clonogenic killing mediated by platinum-based chemotherapy and IR (∼70%-80% killing) relative to young fibroblasts (5 months and 1 year; ∼10%-20% killing) and adult fibroblasts (20 years old; ∼10%-30% killing). Old fibroblasts also displayed significantly increased (2-4-fold) steady-state levels of O (©2017 American Association for Cancer Research.) |
References: | Biochem Med Metab Biol. 1994 Feb;51(1):35-42. (PMID: 8192914) J Biol Chem. 2012 Aug 3;287(32):27255-64. (PMID: 22689576) Plast Reconstr Surg. 2011 Feb;127(2):560-8. (PMID: 21285760) Antioxid Redox Signal. 2003 Oct;5(5):557-61. (PMID: 14580310) Carcinogenesis. 1996 Aug;17(8):1633-9. (PMID: 8761419) N Engl J Med. 2009 Oct 8;361(15):1475-85. (PMID: 19812404) In Vivo. 2007 Mar-Apr;21(2):141-6. (PMID: 17436562) Cancer Control. 2007 Jan;14(1):44-56. (PMID: 17242670) Radiat Res. 2009 Dec;172(6):737-45. (PMID: 19929420) Arch Biochem Biophys. 1973 Sep;158(1):396-400. (PMID: 4354035) Cancer Metastasis Rev. 2004 Aug-Dec;23(3-4):311-22. (PMID: 15197331) Oxid Med Cell Longev. 2016;2016:3565127. (PMID: 27247702) Adv Exp Med Biol. 1977;78:67-82. (PMID: 197811) J Biol Chem. 2012 Mar 30;287(14):10990-1001. (PMID: 22334657) Methods. 2002 Apr;26(4):307-16. (PMID: 12054921) Curr Opin Genet Dev. 2013 Feb;23(1):53-62. (PMID: 23317514) Nat Protoc. 2006;1(5):2315-9. (PMID: 17406473) Eur J Pharmacol. 2014 Oct 5;740:364-78. (PMID: 25058905) Cancer Res. 2006 Aug 1;66(15):7615-20. (PMID: 16885361) Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10469-74. (PMID: 11517304) Radiother Oncol. 2013 Sep;108(3):362-9. (PMID: 23849169) Aging (Albany NY). 2009 May 22;1(6):557-72. (PMID: 20195383) Antioxid Redox Signal. 2011 Sep 15;15(6):1669-78. (PMID: 21050134) J Invest Dermatol. 2013 Apr;133(4):1088-96. (PMID: 23190879) J Appl Physiol. 1953 Sep;6(3):189-93. (PMID: 13096460) Am J Physiol. 1998 Jan;274(1 Pt 1):L127-33. (PMID: 9458810) Radiat Res. 2015 Mar;183(3):262-70. (PMID: 25706776) Pharmacol Rev. 2016 Jan;68(1):20-48. (PMID: 26589414) Radiother Oncol. 1995 Aug;36(2):107-20. (PMID: 7501808) Methods Enzymol. 2009;457:231-53. (PMID: 19426871) In Vivo. 2008 May-Jun;22(3):305-9. (PMID: 18610740) J Biol Chem. 1960 Nov;235:3322-9. (PMID: 13738472) J Clin Oncol. 2009 Jun 10;27(17):2758-65. (PMID: 19403886) J Am Geriatr Soc. 1972 Apr;20(4):145-7. (PMID: 5016631) PLoS One. 2015 Dec 04;10(12):e0143007. (PMID: 26636574) Aging Cell. 2006 Oct;5(5):379-89. (PMID: 16911562) J Biol Chem. 2011 Aug 5;286(31):27103-10. (PMID: 21659507) J Biol Chem. 1951 Nov;193(1):265-75. (PMID: 14907713) Front Biosci. 2008 May 01;13:6554-79. (PMID: 18508680) Int J Mol Sci. 2015 Jul 13;16(7):15918-53. (PMID: 26184181) Antioxid Redox Signal. 2010 Jun 15;12(12):1431-70. (PMID: 19803744) J Invest Dermatol. 2017 Mar;137(3):576-586. (PMID: 27794421) Am J Physiol Cell Physiol. 2005 Jun;288(6):C1440-50. (PMID: 15647387) Int J Mol Sci. 2011;12(9):6226-39. (PMID: 22016654) Eur J Cancer Care (Engl). 2002 Mar;11(1):33-43. (PMID: 11966833) Curr Med Chem. 2004 May;11(9):1105-12. (PMID: 15134509) Anal Biochem. 1989 May 15;179(1):8-18. (PMID: 2547324) Am J Respir Cell Mol Biol. 2003 Jul;29(1):88-97. (PMID: 12600822) |
معلومات مُعتمدة: | R01 CA111365 United States CA NCI NIH HHS; P30 ES005605 United States ES NIEHS NIH HHS; P30 CA086862 United States CA NCI NIH HHS; R01 NS056244 United States NS NINDS NIH HHS; T32 CA078586 United States CA NCI NIH HHS; R01 CA182804 United States CA NCI NIH HHS; T32 GM007337 United States GM NIGMS NIH HHS |
المشرفين على المادة: | 0 (Antineoplastic Agents) 11062-77-4 (Superoxides) EC 1.15.1.1 (Superoxide Dismutase) Q20Q21Q62J (Cisplatin) |
تواريخ الأحداث: | Date Created: 20170803 Date Completed: 20171030 Latest Revision: 20181113 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC5600863 |
DOI: | 10.1158/0008-5472.CAN-17-0106 |
PMID: | 28765155 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1538-7445 |
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DOI: | 10.1158/0008-5472.CAN-17-0106 |