دورية أكاديمية
MicroRNA Changes in Cerebrospinal Fluid After Subarachnoid Hemorrhage.
| العنوان: | MicroRNA Changes in Cerebrospinal Fluid After Subarachnoid Hemorrhage. |
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| المؤلفون: | Bache S; From the Departments of Neuroanaesthesiology (S.B., K.M.) and Neurosurgery (R.R.), The Neuroscience Centre, and Centre for Genomic Medicine (S.B., M.R., F.C.N.), Rigshospitalet, and Department of Anaesthesia, Frederiksberg Hospital (F.P.L.), University of Copenhagen, Denmark. bache@dadlnet.dk., Rasmussen R; From the Departments of Neuroanaesthesiology (S.B., K.M.) and Neurosurgery (R.R.), The Neuroscience Centre, and Centre for Genomic Medicine (S.B., M.R., F.C.N.), Rigshospitalet, and Department of Anaesthesia, Frederiksberg Hospital (F.P.L.), University of Copenhagen, Denmark., Rossing M; From the Departments of Neuroanaesthesiology (S.B., K.M.) and Neurosurgery (R.R.), The Neuroscience Centre, and Centre for Genomic Medicine (S.B., M.R., F.C.N.), Rigshospitalet, and Department of Anaesthesia, Frederiksberg Hospital (F.P.L.), University of Copenhagen, Denmark., Laigaard FP; From the Departments of Neuroanaesthesiology (S.B., K.M.) and Neurosurgery (R.R.), The Neuroscience Centre, and Centre for Genomic Medicine (S.B., M.R., F.C.N.), Rigshospitalet, and Department of Anaesthesia, Frederiksberg Hospital (F.P.L.), University of Copenhagen, Denmark., Nielsen FC; From the Departments of Neuroanaesthesiology (S.B., K.M.) and Neurosurgery (R.R.), The Neuroscience Centre, and Centre for Genomic Medicine (S.B., M.R., F.C.N.), Rigshospitalet, and Department of Anaesthesia, Frederiksberg Hospital (F.P.L.), University of Copenhagen, Denmark., Møller K; From the Departments of Neuroanaesthesiology (S.B., K.M.) and Neurosurgery (R.R.), The Neuroscience Centre, and Centre for Genomic Medicine (S.B., M.R., F.C.N.), Rigshospitalet, and Department of Anaesthesia, Frederiksberg Hospital (F.P.L.), University of Copenhagen, Denmark. |
| المصدر: | Stroke [Stroke] 2017 Sep; Vol. 48 (9), pp. 2391-2398. Date of Electronic Publication: 2017 Aug 02. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0235266 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4628 (Electronic) Linking ISSN: 00392499 NLM ISO Abbreviation: Stroke Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1998- : Baltimore, Md. : Lippincott Williams & Wilkins Original Publication: Dallas : American Heart Association |
| مواضيع طبية MeSH: | Brain Ischemia/*genetics , MicroRNAs/*cerebrospinal fluid , Subarachnoid Hemorrhage/*genetics, Adult ; Aged ; Brain Ischemia/cerebrospinal fluid ; Case-Control Studies ; Female ; High-Throughput Nucleotide Sequencing ; Humans ; Male ; Middle Aged ; Prospective Studies ; Real-Time Polymerase Chain Reaction ; Sequence Analysis, RNA ; Subarachnoid Hemorrhage/cerebrospinal fluid |
| مستخلص: | Background and Purpose: Delayed cerebral ischemia (DCI) accounts for a major part of the morbidity and mortality after aneurysmal subarachnoid hemorrhage (SAH). MicroRNAs (miRNAs) are pathophysiologically involved in acute cerebral ischemia. This study compared miRNA profiles in cerebrospinal fluid from neurologically healthy patients, as well as SAH patients with and without subsequent development of DCI. Methods: In a prospective case-control study of SAH patients treated with external ventricular drainage and neurologically healthy patients, miRNA profiles in cerebrospinal fluid were screened and validated using 2 different high-throughput real-time quantification polymerase chain reaction techniques. The occurrence of DCI was documented in patient charts and subsequently reviewed independently by 2 physicians. Results: MiRNA profiles from 27 SAH patients and 10 neurologically healthy patients passed quality control. In the validation, 66 miRNAs showed a relative increase in cerebrospinal fluid from SAH patients compared with neurologically healthy patients ( P <0.001); 2 (miR-21 and miR-221) showed a relative increase in SAH patients with DCI compared with those without ( P <0.05) in both the screening and validation. Conclusions: SAH is associated with marked changes in the cerebrospinal fluid miRNA profile. These changes could be associated to the development of DCI. Clinical Trial Registration: URL: http://www.clinicaltrials.gov. Unique identifier: NCT01791257. (© 2017 The Authors.) |
| References: | Br J Anaesth. 2012 Sep;109(3):315-29. (PMID: 22879655) J Neurotrauma. 2010 Dec;27(12):2147-56. (PMID: 20883153) J Cereb Blood Flow Metab. 2010 Sep;30(9):1564-76. (PMID: 20606686) Transl Stroke Res. 2014 Dec;5(6):711-8. (PMID: 25127724) J Vasc Res. 2013;50(4):346-54. (PMID: 23860376) J Transl Med. 2015 May 07;13:149. (PMID: 25947950) Am J Transl Res. 2016 Jul 15;8(7):3179-87. (PMID: 27508039) Nat Methods. 2014 Aug;11(8):809-15. (PMID: 24973947) Lancet. 2007 Jan 27;369(9558):306-18. (PMID: 17258671) J Am Heart Assoc. 2017 Apr 25;6(4):null. (PMID: 28442458) PLoS One. 2012;7(10):e47778. (PMID: 23082215) Methods. 2013 Jan;59(1):S1-6. (PMID: 23036329) Nat Rev Clin Oncol. 2011 Jun 07;8(8):467-77. (PMID: 21647195) Ann Clin Biochem. 2008 May;45(Pt 3):238-44. (PMID: 18482910) J Neurosurg. 2017 Apr;126(4):1131-1139. (PMID: 27128592) Nucleic Acids Res. 2010 Nov;38(20):7248-59. (PMID: 20615901) Circ Res. 2007 Jun 8;100(11):1579-88. (PMID: 17478730) J Neurol Sci. 2015 Aug 15;355(1-2):113-9. (PMID: 26055311) Stroke. 2010 Oct;41(10 ):2391-5. (PMID: 20798370) Biomed Res Int. 2015;2015:379071. (PMID: 26421286) Genome Biol. 2009;10 (6):R64. (PMID: 19531210) Physiol Genomics. 2014 Nov 1;46(21):789-97. (PMID: 25159851) Bioinformation. 2006 Nov 22;1(7):251-2. (PMID: 17597901) Neurosurgery. 2007 Apr;60(4):674-9; discussion 679-80. (PMID: 17415204) Cochrane Database Syst Rev. 2007 Jul 18;(3):CD000277. (PMID: 17636626) J Mol Cell Biol. 2011 Feb;3(1):44-50. (PMID: 21278451) Exp Brain Res. 2012 Jan;216(2):225-30. (PMID: 22094713) J Cereb Blood Flow Metab. 2008 Nov;28(11):1761-70. (PMID: 18628782) Biosci Rep. 2017 Feb 23;37(1):null. (PMID: 28115593) Brain Behav Immun. 2015 Oct;49:75-85. (PMID: 25934573) |
| فهرسة مساهمة: | Keywords: brain injuries; cerebrospinal fluid; microRNAs; real-time polymerase chain reaction; stroke; subarachnoid hemorrhage |
| سلسلة جزيئية: | ClinicalTrials.gov NCT01791257 |
| المشرفين على المادة: | 0 (MicroRNAs) |
| تواريخ الأحداث: | Date Created: 20170804 Date Completed: 20170926 Latest Revision: 20181113 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC5571886 |
| DOI: | 10.1161/STROKEAHA.117.017804 |
| PMID: | 28768799 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1524-4628 |
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| DOI: | 10.1161/STROKEAHA.117.017804 |