دورية أكاديمية
The risk of cancer as a result of elevated levels of nitrate in drinking water and vegetables in Central India.
| العنوان: | The risk of cancer as a result of elevated levels of nitrate in drinking water and vegetables in Central India. |
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| المؤلفون: | Taneja P; Academy of Scientific and Innovation Research, Water Technology & Management Division, CSIR-National Environmental Engineering Research Institute (CSIR-NEERI), Academic Council of Scientific & Innovative Research, Nehru Marg, Nagpur 440020, India., Labhasetwar P; Water Technology & Management Division, CSIR-National Environment and Engineering Research Institute (CSIR-NEERI), Nehru Marg, Nagpur 440020, India E-mail: pk_labhasetwar@neeri.res.in., Nagarnaik P; Water Technology & Management Division, CSIR-National Environment and Engineering Research Institute (CSIR-NEERI), Nehru Marg, Nagpur 440020, India E-mail: pk_labhasetwar@neeri.res.in., Ensink JHJ; London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK; deceased. |
| المصدر: | Journal of water and health [J Water Health] 2017 Aug; Vol. 15 (4), pp. 602-614. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: IWA Pub Country of Publication: England NLM ID: 101185420 Publication Model: Print Cited Medium: Print ISSN: 1477-8920 (Print) Linking ISSN: 14778920 NLM ISO Abbreviation: J Water Health Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London ; Avenel, NJ : IWA Pub., c2003- |
| مواضيع طبية MeSH: | Environmental Exposure* , Food Contamination*, Drinking Water/*analysis , Nitrates/*analysis , Stomach Neoplasms/*epidemiology , Vegetables/*chemistry, Adolescent ; Adult ; Aged ; Aged, 80 and over ; Case-Control Studies ; Child ; Environmental Monitoring ; Female ; Humans ; India/epidemiology ; Male ; Middle Aged ; Risk Factors ; Stomach Neoplasms/chemically induced ; Young Adult |
| مستخلص: | The objective of the present study was to determine the effect of nitrates on the incidence of gastrointestinal (GI) cancer development. Nitrate converted to nitrite under reducing conditions of gut results in the formation of N-nitrosamines which are linked to an increased gastric cancer risk. A population of 234 individuals with 78 cases of GI cancer and 156 controls residing at urban and rural settings in Nagpur and Bhandara districts of India were studied for 2 years using a case-control study. A detailed survey of 16 predictor variables using Formhub software was carried out. Nitrate concentrations in vegetables and primary drinking water supplies were measured. The logistic regression model showed that nitrate was statistically significant in predicting increasing risk of cancer when potential confounders were kept at base level (P value of 0.001 nitrate in drinking water; 0.003 for nitrate in vegetable) at P < 0.01. Exposure to nitrate in drinking water at >45 mg/L level of nitrate was associated with a higher risk of GI cancers. Analysis suggests that nitrate concentration in drinking water was found statistically significant in predicting cancer risk with an odds ratio of 1.20. |
| المشرفين على المادة: | 0 (Drinking Water) 0 (Nitrates) |
| تواريخ الأحداث: | Date Created: 20170804 Date Completed: 20171103 Latest Revision: 20220409 |
| رمز التحديث: | 20231215 |
| DOI: | 10.2166/wh.2017.283 |
| PMID: | 28771157 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1477-8920 |
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| DOI: | 10.2166/wh.2017.283 |