دورية أكاديمية
أعرض في EDS

Self-reported pregnancy exposures and placental DNA methylation in the MARBLES prospective autism sibling study.

التفاصيل البيبلوغرافية
العنوان: Self-reported pregnancy exposures and placental DNA methylation in the MARBLES prospective autism sibling study.
المؤلفون: Schmidt RJ; Department of Public Health Sciences, UC Davis School of Medicine, Davis, CA, USA.; MIND Institute, UC Davis School of Medicine, Davis, CA, USA., Schroeder DI; Department of Medical Microbiology and Immunology, Genome Center, UC Davis School of Medicine, Davis, CA, USA., Crary-Dooley FK; Department of Medical Microbiology and Immunology, Genome Center, UC Davis School of Medicine, Davis, CA, USA., Barkoski JM; Graduate Group in Epidemiology, UC Davis School of Medicine, Davis, CA, USA., Tancredi DJ; Department of Pediatrics, UC Davis School of Medicine, Davis, CA, USA., Walker CK; MIND Institute, UC Davis School of Medicine, Davis, CA, USA.; Department of Obstetrics and Gynecology, UC Davis School of Medicine, Davis, CA, USA., Ozonoff S; MIND Institute, UC Davis School of Medicine, Davis, CA, USA.; Department of Psychiatry and Behavioral Sciences, UC Davis School of Medicine, Davis, CA, USA., Hertz-Picciotto I; Department of Public Health Sciences, UC Davis School of Medicine, Davis, CA, USA.; MIND Institute, UC Davis School of Medicine, Davis, CA, USA., LaSalle JM; MIND Institute, UC Davis School of Medicine, Davis, CA, USA.; Department of Medical Microbiology and Immunology, Genome Center, UC Davis School of Medicine, Davis, CA, USA.
المصدر: Environmental epigenetics [Environ Epigenet] 2016 Dec; Vol. 2 (4). Date of Electronic Publication: 2016 Dec 01.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 101675941 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2058-5888 (Print) Linking ISSN: 20585888 NLM ISO Abbreviation: Environ Epigenet Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Oxford : Oxford University Press, [2015]-
مستخلص: Human placenta is a fetal-derived tissue that offers a unique sample of epigenetic and environmental exposures present in utero. In the MARBLES prospective pregnancy study of high-risk younger siblings of children with autism spectrum disorder (ASD), pregnancy and environmental factors collected by maternal interviews were examined as predictors of placental DNA methylation, including partially methylated domains (PMDs), an embryonic feature of the placental methylome. DNA methylation data from MethylC-seq analysis of 47 placentas of children clinically diagnosed at 3 years with ASD or typical development using standardized assessments were examined in relation to: child's gestational age, birth-weight, and diagnosis; maternal pre-pregnancy body mass index, smoking, education, parity, height, prenatal vitamin and folate intake; home ownership; pesticides professionally applied to lawns or gardens or inside homes, pet flea/tick pouches, collars, or soaps/shampoos used in the 3 months prior to or during pregnancy. Sequencing run, order, and coverage, and child race and sex were considered as potential confounders. Akaike information criterion was used to select the most parsimonious among candidate models. Final prediction models used sandwich estimators to produce homoscadisticity-robust estimates of the 95% confidence interval (CI) and P -values controlled the false discovery rate at 5%. The strongest, most robust associations were between pesticides professionally applied outside the home and higher average methylation over PMDs [0.45 (95% CI 0.17, 0.72), P = 0.03] and a reduced proportion of the genome in PMDs [-0.42 (95% CI - 0.67 to -0.17), P = 0.03]. Pesticide exposures could alter placental DNA methylation more than other factors.
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معلومات مُعتمدة: P01 ES011269 United States ES NIEHS NIH HHS; R01 ES020392 United States ES NIEHS NIH HHS; U54 HD079125 United States HD NICHD NIH HHS; S10 RR029668 United States RR NCRR NIH HHS; P30 ES023513 United States ES NIEHS NIH HHS; R01 ES025574 United States ES NIEHS NIH HHS; S10 RR027303 United States RR NCRR NIH HHS; UL1 TR000002 United States TR NCATS NIH HHS; R01 ES021707 United States ES NIEHS NIH HHS
فهرسة مساهمة: Keywords: autism spectrum disorders; environmental factors; high-risk cohort; pesticides; placenta DNA methylation; pregnancy
تواريخ الأحداث: Date Created: 20170808 Latest Revision: 20201001
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC5538262
DOI: 10.1093/eep/dvw024
PMID: 28781890
قاعدة البيانات: MEDLINE
الوصف
تدمد:2058-5888
DOI:10.1093/eep/dvw024