دورية أكاديمية
Hyperbaric oxygen therapy for five days increases blood-brain barrier permeability.
| العنوان: | Hyperbaric oxygen therapy for five days increases blood-brain barrier permeability. |
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| المؤلفون: | Tatar S; Department of Underwater and Hyperbaric Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey., Orhan N; Department of Neuroscience, The Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey., Yilmaz CU; Department of Laboratory Animal Biology, The Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey., Arican N; Department of Forensic Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey., Ahishali B; Department of Histology and Embryology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey., Kucuk M; Department of Laboratory Animal Biology, The Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey., Elmas I; Department of Forensic Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey., Kaya M; Department of Physiology, Koç University School of Medicine, Istanbul, Turkey., Toklu AS; Department of Underwater and Hyperbaric Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. |
| المصدر: | Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc [Undersea Hyperb Med] 2017 Jul-Aug; Vol. 44 (4), pp. 345-355. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Undersea and Hyperbaric Medical Society Country of Publication: United States NLM ID: 9312954 Publication Model: Print Cited Medium: Print ISSN: 1066-2936 (Print) Linking ISSN: 10662936 NLM ISO Abbreviation: Undersea Hyperb Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Bethesda, Md. : Undersea and Hyperbaric Medical Society Original Publication: Bethesda, Md. : The Society, c1993- |
| مواضيع طبية MeSH: | Blood-Brain Barrier/*metabolism , Cerebral Cortex/*chemistry , Glutathione Peroxidase/*analysis , Hippocampus/*chemistry , Hyperbaric Oxygenation/*adverse effects , Malondialdehyde/*analysis , Superoxide Dismutase/*analysis, Animals ; Capillaries/ultrastructure ; Cerebral Cortex/blood supply ; Female ; Hippocampus/blood supply ; Horseradish Peroxidase/pharmacokinetics ; Hyperbaric Oxygenation/methods ; Microscopy, Electron ; Permeability ; Rats ; Rats, Wistar ; Time Factors |
| مستخلص: | This study aimed to explore the effects of hyperbaric oxygen (HBO₂) on blood-brain barrier (BBB) integrity in rats, when administered for one (at 2.5 ATA, 3 HBO₂ sessions a day) and five days (at 2.5 ATA, 3 HBO₂ sessions a day for the first two days, and twice a day for the last three days). Horseradish peroxidase (HRP) was used to evaluate the BBB permeability. Superoxide dismutase (SOD) activity, glutathione (GSH) and malondialdehyde (MDA) levels were measured in the cerebral cortex and hippocampus regions. Frequent vesicles containing HRP reaction products were observed in capillary endothelial cells in the cerebral cortex and hippocampus of rats subjected to HBO₂. The accumulation of HRP reaction products in these brain regions was significantly higher than that of control animals (P ⟨ 0.01). In animals that received HBO₂, MDA levels (P ⟨ 0.01 for five days) and GSH (p ⟨ 0.05 for one day, and P ⟨ 0.01 for five days) were decreased in the cerebral cortex, whereas SOD activities slightly increased in this region. In animals that received HBO₂ significant decreases in MDA (P ⟨ 0.05 for one day; P ⟨ 0.01 for five days) and GSH (P ⟨ 0.05 for five days) levels were observed in the hippocampus region, but SOD activities decreased in this region. We showed that HBO₂ administered with the doses described above impaired BBB integrity in otherwise healthy rats. Therefore, we suggest that the results of this study should be taken into consideration when patients are exposed to HBO₂ with the same doses. Competing Interests: The authors of this paper declare no conflicts of interest exist with this submission. (Copyright© Undersea and Hyperbaric Medical Society.) |
| فهرسة مساهمة: | Keywords: blood-brain barrier; glutathione; horseradish peroxidase; hyperbaric oxygen therapy; malondialdehyde; superoxide dismutase |
| المشرفين على المادة: | 4Y8F71G49Q (Malondialdehyde) EC 1.11.1.- (Horseradish Peroxidase) EC 1.11.1.9 (Glutathione Peroxidase) EC 1.15.1.1 (Superoxide Dismutase) |
| تواريخ الأحداث: | Date Created: 20170808 Date Completed: 20180605 Latest Revision: 20191113 |
| رمز التحديث: | 20221213 |
| DOI: | 10.22462/7.8.2017.7 |
| PMID: | 28783891 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1066-2936 |
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| DOI: | 10.22462/7.8.2017.7 |