دورية أكاديمية
Treatment failure of bacterial vaginosis is not associated with higher loads of Atopobium vaginae and Gardnerella vaginalis.
| العنوان: | Treatment failure of bacterial vaginosis is not associated with higher loads of Atopobium vaginae and Gardnerella vaginalis. |
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| المؤلفون: | Ferreira CST; Department of Pathology, Botucatu Medical School, UNESP - Univ Estadual Paulista, Botucatu, Brazil., Donders GG; Femicare vzw, Clinical Research for Women, Gasthuismolenstraat 31, 3300, Tienen, Belgium.; Department of Obstetrics and Gynecology, Antwerp University Hospital, Edegem, Belgium., Parada CMGL; Department of Nursing, Botucatu Medical School, UNESP - Univ Estadual Paulista, Botucatu, Brazil., Tristão ADR; Department of Gynecology and Obstetrics, Botucatu Medical School, UNESP - Univ Estadual Paulista, Botucatu, Brazil., Fernandes T; Department of Basic Pathology, Setor de Ciências Biológicas, UFPR - Univ Federal do Paraná, Curitiba, Brazil., da Silva MG; Department of Pathology, Botucatu Medical School, UNESP - Univ Estadual Paulista, Botucatu, Brazil., Marconi C; Department of Pathology, Botucatu Medical School, UNESP - Univ Estadual Paulista, Botucatu, Brazil.; Department of Basic Pathology, Setor de Ciências Biológicas, UFPR - Univ Federal do Paraná, Curitiba, Brazil. |
| المصدر: | Journal of medical microbiology [J Med Microbiol] 2017 Aug; Vol. 66 (8), pp. 1217-1224. Date of Electronic Publication: 2017 Aug 10. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Microbiology Society Country of Publication: England NLM ID: 0224131 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5644 (Electronic) Linking ISSN: 00222615 NLM ISO Abbreviation: J Med Microbiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2015- : London : Microbiology Society Original Publication: 1968-1995: Edinburgh, Livingstone. |
| مواضيع طبية MeSH: | Actinobacteria/*drug effects , Gardnerella vaginalis/*drug effects , Vaginosis, Bacterial/*drug therapy, Actinobacteria/genetics ; Actinobacteria/isolation & purification ; Actinobacteria/physiology ; Adolescent ; Adult ; Bacterial Load/drug effects ; Brazil ; Female ; Gardnerella vaginalis/genetics ; Gardnerella vaginalis/isolation & purification ; Gardnerella vaginalis/physiology ; Humans ; Middle Aged ; Treatment Failure ; Vagina/microbiology ; Vaginosis, Bacterial/microbiology ; Young Adult |
| مستخلص: | Purpose: Cervicovaginal Atopobium vaginae and Gardnerella vaginalis are strongly associated with bacterial vaginosis (BV) and are the main components of vaginal biofilms. The low efficacy of BV treatment with metronidazole may be due to the presence of such biofilms. Thus, the aim of this study was to compare the pretreatment cervicovaginal loads of A. vaginae and G. vaginalis for women who restored normal flora and those who persisted with BV after a full course of oral metronidazole. Methodology: In this cross-sectional study, 309 reproductive-aged women were recruited in a primary health care service in Botucatu, Brazil. Cervicovaginal samples were tested for genital tract infections, microscopic classification of local microbiota and molecular quantification of A. vaginae and G. vaginalis. Results: All the participants with concurrent cervicovaginal infections (n=64) were excluded. A total of 84 out of 245 (34.3 %) women had BV at enrolment and 43 (51.2 %) of them completed the treatment and returned for follow-up. Evaluation of the vaginal microbiota at follow-up showed that 29 (67.4 %) women restored normal vaginal flora, while 14 (32.6 %) still had BV. The pretreatment loads of G. vaginalis were lower in women with treatment failure (P=0.001) compared to those who successfully restored normal flora. The loads of A. vaginae did not differ between the groups. Conclusion: Although G. vaginalis produces several virulence factors and its loads correlate positively with those of A. vaginae, higher cervicovaginal quantities of these bacteria are not associated with treatment failure of BV after oral metronidazole. |
| تواريخ الأحداث: | Date Created: 20170810 Date Completed: 20170830 Latest Revision: 20191210 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1099/jmm.0.000561 |
| PMID: | 28792372 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1473-5644 |
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| DOI: | 10.1099/jmm.0.000561 |