دورية أكاديمية
أعرض في EDS

Optimization of therapeutic drug monitoring of vancomycin in patients with chronic hemodialysis
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التفاصيل البيبلوغرافية
العنوان: Optimization of therapeutic drug monitoring of vancomycin in patients with chronic hemodialysis
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المؤلفون: Mahmoud LB, Chaabouni Y, Ghozzi H, Feriani H, Hakim A, Kharrat M, Marrakchi C, Sahnoun Z, Jmaa MB, Zeghal K, Hachicha J
المصدر: Clinical nephrology [Clin Nephrol] 2017 Oct; Vol. 88 (10), pp. 198-204.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Dustri-Verlag Dr. Karl Feistle Country of Publication: Germany NLM ID: 0364441 Publication Model: Print Cited Medium: Internet ISSN: 0301-0430 (Print) Linking ISSN: 03010430 NLM ISO Abbreviation: Clin Nephrol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: München-Deisenhofen, Dustri-Verlag Dr. Karl Feistle.
مواضيع طبية MeSH: Anti-Bacterial Agents/*therapeutic use , Drug Monitoring/*methods , Renal Dialysis/*adverse effects , Staphylococcal Infections/*drug therapy , Vancomycin/*therapeutic use, Administration, Intravenous ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents/administration & dosage ; Female ; Humans ; Kidney Failure, Chronic/therapy ; Male ; Methicillin-Resistant Staphylococcus aureus ; Middle Aged ; Prospective Studies ; Staphylococcal Infections/etiology ; Vancomycin/administration & dosage ; Young Adult
مستخلص: Purpose: To validate a simplified vancomycin monitoring algorithm in patients on chronic hemodialysis who required intravenous vancomycin for at least 3 weeks.
Materials and Methods: In this prospective study, all hemodialysis patients who were admitted between April 1, 2013, and March 31, 2015, in our unit for suspected or confirmed methicillin-resistant Staphylococcus aureus infection that required vancomycin were enrolled. All patients were categorized into two groups. In group 1 (standard vancomycin dosing algorithm), the maintenance doses of vancomycin were adjusted according to the pre-hemodialysis vancomycin concentrations determined before each hemodialysis session. In group 2 (simplified vancomycin dosing algorithm), pre-dialysis vancomycin trough levels were taken before the 2 nd and the 6 th session of hemodialysis. Maintenance doses were adjusted according to the residual concentrations of vancomycin.
Results: A total of 101 blood samples were collected, the average plasma concentration of vancomycin was 13.1 ± 3.8 µg/mL. 64 (63.4%) levels fell out of the therapeutic range. Seven (6.9%) of these exceeded the therapeutic range and 30 (29.7%) were lower. After the loading dose, the average plasma concentration was 11.2 ± 3.4 µg/mL. There were no statistically significant differences between the two groups with respect to the average plasma concentration of vancomycin and the proportion of vancomycin trough levels in the target range.
Conclusion: The vancomycin dosing algorithm using limited concentration monitoring for hemodialysis patients achieved drug concentrations comparable to those found with more frequent monitoring and resulted in significant cost savings.
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المشرفين على المادة: 0 (Anti-Bacterial Agents)
6Q205EH1VU (Vancomycin)
تواريخ الأحداث: Date Created: 20170811 Date Completed: 20180423 Latest Revision: 20221222
رمز التحديث: 20231215
DOI: 10.5414/CN109091
PMID: 28793955
قاعدة البيانات: MEDLINE
الوصف
تدمد:0301-0430
DOI:10.5414/CN109091