دورية أكاديمية
Optimization of therapeutic drug monitoring of vancomycin in patients with chronic hemodialysis .
العنوان: | Optimization of therapeutic drug monitoring of vancomycin in patients with chronic hemodialysis . |
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المؤلفون: | Mahmoud LB, Chaabouni Y, Ghozzi H, Feriani H, Hakim A, Kharrat M, Marrakchi C, Sahnoun Z, Jmaa MB, Zeghal K, Hachicha J |
المصدر: | Clinical nephrology [Clin Nephrol] 2017 Oct; Vol. 88 (10), pp. 198-204. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Dustri-Verlag Dr. Karl Feistle Country of Publication: Germany NLM ID: 0364441 Publication Model: Print Cited Medium: Internet ISSN: 0301-0430 (Print) Linking ISSN: 03010430 NLM ISO Abbreviation: Clin Nephrol Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: München-Deisenhofen, Dustri-Verlag Dr. Karl Feistle. |
مواضيع طبية MeSH: | Anti-Bacterial Agents/*therapeutic use , Drug Monitoring/*methods , Renal Dialysis/*adverse effects , Staphylococcal Infections/*drug therapy , Vancomycin/*therapeutic use, Administration, Intravenous ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents/administration & dosage ; Female ; Humans ; Kidney Failure, Chronic/therapy ; Male ; Methicillin-Resistant Staphylococcus aureus ; Middle Aged ; Prospective Studies ; Staphylococcal Infections/etiology ; Vancomycin/administration & dosage ; Young Adult |
مستخلص: | Purpose: To validate a simplified vancomycin monitoring algorithm in patients on chronic hemodialysis who required intravenous vancomycin for at least 3 weeks. Materials and Methods: In this prospective study, all hemodialysis patients who were admitted between April 1, 2013, and March 31, 2015, in our unit for suspected or confirmed methicillin-resistant Results: A total of 101 blood samples were collected, the average plasma concentration of vancomycin was 13.1 ± 3.8 µg/mL. 64 (63.4%) levels fell out of the therapeutic range. Seven (6.9%) of these exceeded the therapeutic range and 30 (29.7%) were lower. After the loading dose, the average plasma concentration was 11.2 ± 3.4 µg/mL. There were no statistically significant differences between the two groups with respect to the average plasma concentration of vancomycin and the proportion of vancomycin trough levels in the target range. Conclusion: The vancomycin dosing algorithm using limited concentration monitoring for hemodialysis patients achieved drug concentrations comparable to those found with more frequent monitoring and resulted in significant cost savings. . |
المشرفين على المادة: | 0 (Anti-Bacterial Agents) 6Q205EH1VU (Vancomycin) |
تواريخ الأحداث: | Date Created: 20170811 Date Completed: 20180423 Latest Revision: 20221222 |
رمز التحديث: | 20231215 |
DOI: | 10.5414/CN109091 |
PMID: | 28793955 |
قاعدة البيانات: | MEDLINE |
تدمد: | 0301-0430 |
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DOI: | 10.5414/CN109091 |