دورية أكاديمية
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Turmeric Extract Rescues Ethanol-Induced Developmental Defect in the Zebrafish Model for Fetal Alcohol Spectrum Disorder (FASD).

التفاصيل البيبلوغرافية
العنوان: Turmeric Extract Rescues Ethanol-Induced Developmental Defect in the Zebrafish Model for Fetal Alcohol Spectrum Disorder (FASD).
المؤلفون: Muralidharan P; Dept. of Biology, Indiana Univ.-Purdue Univ. Indianapolis, Indianapolis, Ind., 46202, U.S.A., Connors CT; Dept. of Biology, Indiana Univ.-Purdue Univ. Indianapolis, Indianapolis, Ind., 46202, U.S.A., Mohammed AS; Dept. of Biology, Indiana Univ.-Purdue Univ. Indianapolis, Indianapolis, Ind., 46202, U.S.A., Sarmah S; Dept. of Biology, Indiana Univ.-Purdue Univ. Indianapolis, Indianapolis, Ind., 46202, U.S.A., Marrs K; Dept. of Biology, Indiana Univ.-Purdue Univ. Indianapolis, Indianapolis, Ind., 46202, U.S.A., Marrs JA; Dept. of Biology, Indiana Univ.-Purdue Univ. Indianapolis, Indianapolis, Ind., 46202, U.S.A., Chism GW; Dept. of Biology, Indiana Univ.-Purdue Univ. Indianapolis, Indianapolis, Ind., 46202, U.S.A.
المصدر: Journal of food science [J Food Sci] 2017 Sep; Vol. 82 (9), pp. 2221-2225. Date of Electronic Publication: 2017 Aug 10.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley on behalf of the Institute of Food Technologists Country of Publication: United States NLM ID: 0014052 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1750-3841 (Electronic) Linking ISSN: 00221147 NLM ISO Abbreviation: J Food Sci Subsets: MEDLINE
أسماء مطبوعة: Publication: Malden, Mass. : Wiley on behalf of the Institute of Food Technologists
Original Publication: Champaign, Ill. Institute of Food Technologists
مواضيع طبية MeSH: Curcuma/*chemistry , Ethanol/*toxicity , Fetal Alcohol Spectrum Disorders/*prevention & control , Plant Extracts/*administration & dosage , Zebrafish/*growth & development, Animals ; Curcuma/anatomy & histology ; Dietary Supplements/analysis ; Disease Models, Animal ; Embryo, Nonmammalian ; Female ; Fetal Alcohol Spectrum Disorders/physiopathology ; Humans ; Male ; Plant Extracts/analysis
مستخلص: Prenatal ethanol exposure causes the most frequent preventable birth disorder, fetal alcohol spectrum disorder (FASD). The effect of turmeric extracts in rescuing an ethanol-induced developmental defect using zebrafish as a model was determined. Ethanol-induced oxidative stress is one of the major mechanisms underlying FASD. We hypothesize that antioxidant inducing properties of turmeric may alleviate ethanol-induced defects. Curcuminoid content of the turmeric powder extract (5 mg/mL turmeric in ethanol) was determined by UPLC and found to contain Curcumin (124.1 ± 0.2 μg/mL), Desmethoxycurcumin (43.4 ± 0.1 μg/mL), and Bisdemethoxycurcumin (36.6 ± 0.1 μg/mL). Zebrafish embryos were treated with 100 mM (0.6% v/v) ethanol during gastrulation through organogenesis (2 to 48 h postfertilization (hpf)) and supplemented with turmeric extract to obtain total curcuminoid concentrations of 0, 1.16, 1.72, or 2.32 μM. Turmeric supplementation showed significant rescue of the body length at 72 hpf compared to ethanol-treated embryos. The mechanism underlying the rescue remains to be determined.
(© 2017 Institute of Food Technologists®.)
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معلومات مُعتمدة: R21 AA022396 United States AA NIAAA NIH HHS
فهرسة مساهمة: Keywords: ethanol-induced defects; fetal alcohol spectrum disorder; nutritional supplement; turmeric; zebrafish
المشرفين على المادة: 0 (Plant Extracts)
3K9958V90M (Ethanol)
856YO1Z64F (turmeric extract)
تواريخ الأحداث: Date Created: 20170811 Date Completed: 20180212 Latest Revision: 20181202
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC5938731
DOI: 10.1111/1750-3841.13830
PMID: 28796310
قاعدة البيانات: MEDLINE
الوصف
تدمد:1750-3841
DOI:10.1111/1750-3841.13830