دورية أكاديمية
أعرض في EDS

Interfacially Engineered Pyridinium Pseudogemini Surfactants as Versatile and Efficient Supramolecular Delivery Systems for DNA, siRNA, and mRNA.

التفاصيل البيبلوغرافية
العنوان: Interfacially Engineered Pyridinium Pseudogemini Surfactants as Versatile and Efficient Supramolecular Delivery Systems for DNA, siRNA, and mRNA.
المؤلفون: Satyal U; Department of Pharmaceutical Sciences and Moulder Center of Drug Discovery Research, Temple University School of Pharmacy , Philadelphia, Pennsylvania 19140, United States., Draghici B; Department of Pharmaceutical Sciences and Moulder Center of Drug Discovery Research, Temple University School of Pharmacy , Philadelphia, Pennsylvania 19140, United States., Dragic LL; Department of Pharmaceutical Sciences and Moulder Center of Drug Discovery Research, Temple University School of Pharmacy , Philadelphia, Pennsylvania 19140, United States., Zhang Q; Department of Pharmaceutical Sciences and Moulder Center of Drug Discovery Research, Temple University School of Pharmacy , Philadelphia, Pennsylvania 19140, United States., Norris KW; Department of Pharmaceutical Sciences and Moulder Center of Drug Discovery Research, Temple University School of Pharmacy , Philadelphia, Pennsylvania 19140, United States., Madesh M, Brailoiu E, Ilies MA; Department of Pharmaceutical Sciences and Moulder Center of Drug Discovery Research, Temple University School of Pharmacy , Philadelphia, Pennsylvania 19140, United States.
المصدر: ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2017 Sep 06; Vol. 9 (35), pp. 29481-29495. Date of Electronic Publication: 2017 Aug 25.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101504991 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1944-8252 (Electronic) Linking ISSN: 19448244 NLM ISO Abbreviation: ACS Appl Mater Interfaces Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, D.C. : American Chemical Society
مواضيع طبية MeSH: Surface-Active Agents/*chemistry, DNA ; RNA, Messenger ; RNA, Small Interfering ; Transfection
مستخلص: This article presents the synthesis, self-assembly, and biological activity as transfection agents for pDNA, siRNA, and mRNA of novel pyridinium pseudogemini surfactants, interfacially engineered from the most efficient gemini surfactants and lipids generated in our amphiphile research program. Formulation of novel amphiphiles in water revealed supramolecular properties very similar to those of gemini surfactants, despite their lipidlike charge/mass ratio. This dual character was found also to enhance endosomal escape and significantly increase the transfection efficiency. We were also successful in identifying the parameters governing the efficient delivery of pDNA, siRNA, and mRNA, drawing valuable structure-activity and structure-property relationships for each nucleic acid type, and establishing DNA/siRNA/mRNA comparisons. Several supramolecular complexes identified in this study proved to be extremely efficient nucleic acid delivery systems, displaying excellent serum stability and tissue penetration in three-dimensional organoids.
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معلومات مُعتمدة: R01 GM109882 United States GM NIGMS NIH HHS; R01 HL086699 United States HL NHLBI NIH HHS; R01 HL119306 United States HL NHLBI NIH HHS; S10 RR022511 United States RR NCRR NIH HHS
فهرسة مساهمة: Keywords: DNA; amphiphile; mRNA; pyridinium; siRNA; transfection
المشرفين على المادة: 0 (RNA, Messenger)
0 (RNA, Small Interfering)
0 (Surface-Active Agents)
9007-49-2 (DNA)
تواريخ الأحداث: Date Created: 20170816 Date Completed: 20190115 Latest Revision: 20210101
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC7774514
DOI: 10.1021/acsami.7b07066
PMID: 28809098
قاعدة البيانات: MEDLINE
الوصف
تدمد:1944-8252
DOI:10.1021/acsami.7b07066