دورية أكاديمية
أعرض في EDS

Synthesis and characterization of Fe III (μ-OH)Zn II complexes: effects of a second coordination sphere and increase in the chelate ring size on the hydrolysis of a phosphate diester and DNA.

التفاصيل البيبلوغرافية
العنوان: Synthesis and characterization of Fe III (μ-OH)Zn II complexes: effects of a second coordination sphere and increase in the chelate ring size on the hydrolysis of a phosphate diester and DNA.
المؤلفون: Silva GADS; Departamento de Química, Universidade Federal de Santa Catarina, 88040-900 Florianópolis, SC, Brazil. ademir.neves@ufsc.br rosely.peralta@ufsc.br., Amorim AL, Souza B, Gabriel P, Terenzi H, Nordlander E, Neves A, Peralta RA
المصدر: Dalton transactions (Cambridge, England : 2003) [Dalton Trans] 2017 Aug 29; Vol. 46 (34), pp. 11380-11394.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101176026 Publication Model: Print Cited Medium: Internet ISSN: 1477-9234 (Electronic) Linking ISSN: 14779226 NLM ISO Abbreviation: Dalton Trans Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, UK : Royal Society of Chemistry, c2003-
مواضيع طبية MeSH: 2,4-Dinitrophenol/*analogs & derivatives , Chelating Agents/*chemistry , DNA/*chemistry , Iron/*chemistry , Organometallic Compounds/*chemical synthesis , Organophosphates/*chemistry , Zinc/*chemistry, 2,4-Dinitrophenol/chemistry ; Biomimetic Materials/chemical synthesis ; Biomimetic Materials/chemistry ; Chemistry Techniques, Synthetic ; Hydrolases/metabolism ; Hydrolysis ; Ligands ; Models, Molecular ; Molecular Conformation ; Organometallic Compounds/chemistry
مستخلص: The synthesis and characterization of three ligands and their respective heterobinuclear Fe III Zn II complexes were carried out, with the goal of mimicking the active site of purple acid phosphatases (PAPs). The ligand 2-hydroxy-3-(((2-hydroxy-5-methyl-3-(((2-(pyridin-2-yl)ethyl)(pyridin-2-ylmethyl)amino)methyl)benzyl)(pyridin-2ylmethyl)amino)methyl)-5-methylbenzaldehyde (H 2 L 2 ) was synthesized and its complex (Fe III Zn II L 2 ) was used as a basis for comparison with similar complexes previously published in the literature. Subsequent modifications were conducted in the aldehyde group, where 1,2-ethanediamine and 1,4-diaminobutane were used as side chain derivatives. The compounds Fe III Zn II L 2 (1), Fe III Zn II L 2 -et (2) and Fe III Zn II L 2 -but (3) were characterized by spectroscopic methods (infrared and UV-Vis) and ESI-MS spectrometry. Theoretical calculations were performed to provide insights into the complex structures with Fe III Zn II structures. The hydrolytic activity was analyzed both with the model substrate 2,4-BDNPP and with DNA catalyzed by complexes 1, 2 and 3.
المشرفين على المادة: 0 (Chelating Agents)
0 (Ligands)
0 (Organometallic Compounds)
0 (Organophosphates)
2566-26-9 (2,4-dinitrophenylphosphate)
9007-49-2 (DNA)
E1UOL152H7 (Iron)
EC 3.- (Hydrolases)
J41CSQ7QDS (Zinc)
Q13SKS21MN (2,4-Dinitrophenol)
تواريخ الأحداث: Date Created: 20170817 Date Completed: 20180810 Latest Revision: 20180810
رمز التحديث: 20221213
DOI: 10.1039/c7dt02035j
PMID: 28812750
قاعدة البيانات: MEDLINE
الوصف
تدمد:1477-9234
DOI:10.1039/c7dt02035j