دورية أكاديمية
أعرض في EDS

A metabolomics guided exploration of marine natural product chemical space.

التفاصيل البيبلوغرافية
العنوان: A metabolomics guided exploration of marine natural product chemical space.
المؤلفون: Floros DJ; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA.; Skaggs School of Pharmacy and Pharmaceutical Sciences, Collaborative Mass Spectrometry Innovation Center, University of California, San Diego, La Jolla, CA, USA., Jensen PR; Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, USA., Dorrestein PC; Skaggs School of Pharmacy and Pharmaceutical Sciences, Collaborative Mass Spectrometry Innovation Center, University of California, San Diego, La Jolla, CA, USA., Koyama N; Skaggs School of Pharmacy and Pharmaceutical Sciences, Collaborative Mass Spectrometry Innovation Center, University of California, San Diego, La Jolla, CA, USA.; Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan inventory the chemistries associated with 1000 marine microorganisms.
المصدر: Metabolomics : Official journal of the Metabolomic Society [Metabolomics] 2016 Sep; Vol. 12 (9). Date of Electronic Publication: 2016 Aug 09.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 101274889 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1573-3882 (Print) Linking ISSN: 15733882 NLM ISO Abbreviation: Metabolomics Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: New York : Springer, c2006-
مستخلص: Introduction: Natural products from culture collections have enormous impact in advancing discovery programs for metabolites of biotechnological importance. These discovery efforts rely on the metabolomic characterization of strain collections.
Objective: Many emerging approaches compare metabolomic profiles of such collections, but few enable the analysis and prioritization of thousands of samples from diverse organisms while delivering chemistry specific read outs.
Method: In this work we utilize untargeted LC-MS/MS based metabolomics together with molecular networking to.
Result: This approach annotated 76 molecular families (a spectral match rate of 28 %), including clinically and biotechnologically important molecules such as valinomycin, actinomycin D, and desferrioxamine E. Targeting a molecular family produced primarily by one microorganism led to the isolation and structure elucidation of two new molecules designated maridric acids A and B.
Conclusion: Molecular networking guided exploration of large culture collections allows for rapid dereplication of know molecules and can highlight producers of uniques metabolites. These methods, together with large culture collections and growing databases, allow for data driven strain prioritization with a focus on novel chemistries.
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معلومات مُعتمدة: P41 GM103484 United States GM NIGMS NIH HHS; R01 GM085770 United States GM NIGMS NIH HHS; S10 RR029121 United States RR NCRR NIH HHS; T32 EB009380 United States EB NIBIB NIH HHS
فهرسة مساهمة: Keywords: Marine natural products; Mass spectrometry; Metabolomics; Molecular networking
تواريخ الأحداث: Date Created: 20170819 Latest Revision: 20240610
رمز التحديث: 20240610
مُعرف محوري في PubMed: PMC5556696
DOI: 10.1007/s11306-016-1087-5
PMID: 28819353
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-3882
DOI:10.1007/s11306-016-1087-5