دورية أكاديمية
أعرض في EDS

Threonine deficiency decreased intestinal immunity and aggravated inflammation associated with NF-κB and target of rapamycin signalling pathways in juvenile grass carp (Ctenopharyngodon idella) after infection with Aeromonas hydrophila.

التفاصيل البيبلوغرافية
العنوان: Threonine deficiency decreased intestinal immunity and aggravated inflammation associated with NF-κB and target of rapamycin signalling pathways in juvenile grass carp (Ctenopharyngodon idella) after infection with Aeromonas hydrophila.
المؤلفون: Dong YW; 1Animal Nutrition Institute,Sichuan Agricultural University,Chengdu 611130,People's Republic of China., Jiang WD; 1Animal Nutrition Institute,Sichuan Agricultural University,Chengdu 611130,People's Republic of China., Liu Y; 1Animal Nutrition Institute,Sichuan Agricultural University,Chengdu 611130,People's Republic of China., Wu P; 1Animal Nutrition Institute,Sichuan Agricultural University,Chengdu 611130,People's Republic of China., Jiang J; 1Animal Nutrition Institute,Sichuan Agricultural University,Chengdu 611130,People's Republic of China., Kuang SY; 4Animal Nutrition Institute,Sichuan Academy of Animal Science,Chengdu 610066,People's Republic of China., Tang L; 4Animal Nutrition Institute,Sichuan Academy of Animal Science,Chengdu 610066,People's Republic of China., Tang WN; 4Animal Nutrition Institute,Sichuan Academy of Animal Science,Chengdu 610066,People's Republic of China., Zhang YA; 5Institute of Hydrobiology,Chinese Academy of Sciences,Wuhan 430072,People's Republic of China., Zhou XQ; 1Animal Nutrition Institute,Sichuan Agricultural University,Chengdu 611130,People's Republic of China., Feng L; 1Animal Nutrition Institute,Sichuan Agricultural University,Chengdu 611130,People's Republic of China.
المصدر: The British journal of nutrition [Br J Nutr] 2017 Jul; Vol. 118 (2), pp. 92-108.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Published on behalf of the Nutrition Society by CABI Publishing Country of Publication: England NLM ID: 0372547 Publication Model: Print Cited Medium: Internet ISSN: 1475-2662 (Electronic) Linking ISSN: 00071145 NLM ISO Abbreviation: Br J Nutr Subsets: MEDLINE
أسماء مطبوعة: Publication: <2000->: Wallingford, Oxon, UK : Published on behalf of the Nutrition Society by CABI Publishing
Original Publication: [Cambridge, New York] Cambridge University Press.
مواضيع طبية MeSH: Carps/*microbiology , Fish Diseases/*microbiology , Gram-Negative Bacterial Infections/*veterinary , Intestines/*immunology , TOR Serine-Threonine Kinases/*metabolism , Threonine/*deficiency, Aeromonas hydrophila ; Animals ; Antimicrobial Cationic Peptides/genetics ; Blood Proteins ; Carps/immunology ; Cytokines/genetics ; Cytokines/metabolism ; Diet/veterinary ; Down-Regulation/drug effects ; Enteritis/veterinary ; Fish Diseases/immunology ; Fish Proteins/genetics ; Hepcidins ; Immunoglobulin M ; Intestines/enzymology ; Muramidase/metabolism ; NF-kappa B/metabolism ; Signal Transduction/physiology ; Threonine/administration & dosage ; Up-Regulation/drug effects
مستخلص: This study aimed to investigate the impacts of dietary threonine on intestinal immunity and inflammation in juvenile grass carp. Six iso-nitrogenous semi-purified diets containing graded levels of threonine (3·99-21·66 g threonine/kg) were formulated and fed to fishes for 8 weeks, and then challenged with Aeromonas hydrophila for 14 d. Results showed that, compared with optimum threonine supplementation, threonine deficiency (1) decreased the ability of fish against enteritis, intestinal lysozyme activities (except in the distal intestine), acid phosphatase activities, complement 3 (C3) and C4 contents and IgM contents (except in the proximal intestine (PI)), and it down-regulated the transcript abundances of liver-expressed antimicrobial peptide (LEAP)-2A, LEAP-2B, hepcidin, IgZ, IgM and β-defensin1 (except in the PI) (P<0·05); (2) could up-regulate intestinal pro-inflammatory cytokines TNF-α, IL-1β, IL-6, IL-8 and IL-17D mRNA levels partly related to NF-κB signalling; (3) could down-regulate intestinal anti-inflammatory cytokine transforming growth factor (TGF)-β1, TGF-β2, IL-4/13A (not IL-4/13B) and IL-10 mRNA levels partly by target of rapamycin signalling. Finally, on the basis of the specific growth rate, against the enteritis morbidity and IgM contents, the optimum threonine requirements were estimated to be 14·53 g threonine/kg diet (4·48 g threonine/100 g protein), 15.05 g threonine/kg diet (4·64 g threonine/100 g protein) and 15·17 g threonine/kg diet (4·68 g threonine/100 g protein), respectively.
فهرسة مساهمة: Keywords: 4E-BP1 eIF4E-binding protein 1; ACP acid phosphatase; C complement; DI distal intestine; FE feed efficiency; GOT glutamate-oxaloacetate transaminase; GPT glutamate-puruvate transaminase; IKK IκB kinase; INFγ interferon γ; IκBα inhibitor of κBα; LA lysozyme activities; LEAP liver-expressed antimicrobial peptide; MI mid intestine; PAC plasma ammonia content; PI proximal intestine; PWG percentage weight gain; S6K1 ribosomal protein S6 kinases 1; SGR special growth rate; TGF transforming growth factor; TOR target of rapamycin; Immunity; Inflammation; Intestine; Juvenile grass carp (Ctenopharyngodon idella); NF-κB and target of rapamycin signalling; Threonine deficiency
المشرفين على المادة: 0 (Antimicrobial Cationic Peptides)
0 (Blood Proteins)
0 (Cytokines)
0 (Fish Proteins)
0 (Hepcidins)
0 (Immunoglobulin M)
0 (NF-kappa B)
0 (liver-expressed antimicrobial peptide 2, human)
2ZD004190S (Threonine)
EC 2.7.11.1 (TOR Serine-Threonine Kinases)
EC 3.2.1.17 (Muramidase)
تواريخ الأحداث: Date Created: 20170819 Date Completed: 20170825 Latest Revision: 20211204
رمز التحديث: 20221213
DOI: 10.1017/S0007114517001830
PMID: 28820083
قاعدة البيانات: MEDLINE
الوصف
تدمد:1475-2662
DOI:10.1017/S0007114517001830