دورية أكاديمية

Cell cycle dynamics and complement expression distinguishes mature haematopoietic subsets arising from hemogenic endothelium.

التفاصيل البيبلوغرافية
العنوان: Cell cycle dynamics and complement expression distinguishes mature haematopoietic subsets arising from hemogenic endothelium.
المؤلفون: Zape JP; a Cardiovascular Research Institute , University of California San Francisco , San Francisco , CA , USA., Lizama CO; a Cardiovascular Research Institute , University of California San Francisco , San Francisco , CA , USA., Cautivo KM; c Department of Laboratory of Medicine , University of California San Francisco, School of Medicine , San Francisco , CA , USA., Zovein AC; a Cardiovascular Research Institute , University of California San Francisco , San Francisco , CA , USA.; b Department of Pediatrics, Division of Neonatology , University of California San Francisco School of Medicine , San Francisco , CA , USA.
المصدر: Cell cycle (Georgetown, Tex.) [Cell Cycle] 2017 Oct 02; Vol. 16 (19), pp. 1835-1847. Date of Electronic Publication: 2017 Aug 18.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101137841 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1551-4005 (Electronic) Linking ISSN: 15514005 NLM ISO Abbreviation: Cell Cycle Subsets: MEDLINE
أسماء مطبوعة: Publication: 2015- : Philadelphia, PA : Taylor & Francis
Original Publication: Georgetown, TX : Landes Bioscience, c2002-
مواضيع طبية MeSH: Cell Cycle/*genetics , Complement System Proteins/*genetics , Endothelium, Vascular/*metabolism , Hemangioblasts/*metabolism , Hematopoietic Stem Cells/*metabolism, Animals ; Cell Differentiation ; Cell Division ; Complement System Proteins/metabolism ; Embryo, Mammalian ; Endothelium, Vascular/cytology ; Endothelium, Vascular/growth & development ; Female ; Flow Cytometry ; Gene Expression Regulation ; Hemangioblasts/cytology ; Hematopoiesis/genetics ; Hematopoietic Stem Cells/cytology ; Mice ; Mice, Transgenic ; Pregnancy ; Signal Transduction ; Staining and Labeling/methods
مستخلص: The emergence of haematopoietic stem and progenitor cells (HSPCs) from hemogenic endothelium results in the formation of sizeable HSPC clusters attached to the vascular wall. We evaluate the cell cycle and proliferation of HSPCs involved in cluster formation, as well as the molecular signatures from their initial appearance to the point when cluster cells are capable of adult engraftment (definitive HSCs). We uncover a non-clonal origin of HSPC clusters with differing cell cycle, migration, and cell signaling attributes. In addition, we find that the complement cascade is highly enriched in mature HSPC clusters, possibly delineating a new role for this pathway in engraftment.
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معلومات مُعتمدة: DP2 HL117743 United States HL NHLBI NIH HHS; T32 GM008568 United States GM NIGMS NIH HHS
فهرسة مساهمة: Keywords: hematopoiesis; hematopoietic stem cells; hemogenic endothelium
المشرفين على المادة: 9007-36-7 (Complement System Proteins)
تواريخ الأحداث: Date Created: 20170819 Date Completed: 20180605 Latest Revision: 20200930
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC5628647
DOI: 10.1080/15384101.2017.1361569
PMID: 28820341
قاعدة البيانات: MEDLINE
الوصف
تدمد:1551-4005
DOI:10.1080/15384101.2017.1361569