دورية أكاديمية
Orally administered angiotensin-converting enzyme-inhibitors captopril and isoleucine-proline-proline have distinct effects on local renin-angiotensin system and corticosterone synthesis in dextran sulfate sodium-induced colitis in mice.
| العنوان: | Orally administered angiotensin-converting enzyme-inhibitors captopril and isoleucine-proline-proline have distinct effects on local renin-angiotensin system and corticosterone synthesis in dextran sulfate sodium-induced colitis in mice. |
|---|---|
| المؤلفون: | Salmenkari H; Faculty of Medicine, Pharmacology, University of Helsinki, Helsinki, Finland. hanne.salmenkari@helsinki.fi., Holappa M; Faculty of Medicine, Pharmacology, University of Helsinki, Helsinki, Finland., Forsgard RA; Faculty of Medicine, Pharmacology, University of Helsinki, Helsinki, Finland., Korpela R; Faculty of Medicine, Pharmacology, University of Helsinki, Helsinki, Finland., Vapaatalo H; Faculty of Medicine, Pharmacology, University of Helsinki, Helsinki, Finland. |
| المصدر: | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society [J Physiol Pharmacol] 2017 Jun; Vol. 68 (3), pp. 355-362. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Polish Physiological Society Country of Publication: Poland NLM ID: 9114501 Publication Model: Print Cited Medium: Internet ISSN: 1899-1505 (Electronic) Linking ISSN: 08675910 NLM ISO Abbreviation: J Physiol Pharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Krakow : Polish Physiological Society Original Publication: [Kraków] : The Society, [1991- |
| مواضيع طبية MeSH: | Angiotensin-Converting Enzyme Inhibitors/*pharmacology , Captopril/*pharmacology , Colitis/*metabolism , Corticosterone/*metabolism , Oligopeptides/*pharmacology , Renin-Angiotensin System/*drug effects, Administration, Oral ; Animals ; Colitis/chemically induced ; Colitis/genetics ; Colitis/pathology ; Colon/drug effects ; Colon/metabolism ; Colon/pathology ; Cytochrome P-450 CYP1B1/genetics ; Dextran Sulfate ; Interleukin-1beta/metabolism ; Interleukin-6/metabolism ; Male ; Mice, Inbred BALB C ; Peptidyl-Dipeptidase A/genetics ; Peptidyl-Dipeptidase A/metabolism ; Tumor Necrosis Factor-alpha/metabolism |
| مستخلص: | The effects of angiotensin-converting enzyme (ACE) inhibition by an antihypertensive drug, captopril, and milk casein-derived ACE-inhibiting bioactive tripeptide isoleucine-proline-proline (Ile-Pro-Pro), on local renin-angiotensin system (RAS) and glucocorticoid production in the intestine were studied in the dextran sodium sulfate induced colitis in mice. Mice received water or 3% dextran sodium sulfate with or without either 15.7 mg/l captopril or 833 mg/l Ile-Pro-Pro for 7 days. Captopril and Ile-Pro-Pro were found to have distinct effects on local renin-angiotensin system and mRNA expression of glucocorticoid synthesis components in colon in vitro. Captopril reduced intestinal mRNA expression of angiotensin-converting enzyme, angiotensinogen and Cyp11b1, whereas Ile-Pro-Pro reduced angiotensin-converting enzyme protein shedding from colon. Neither captopril nor Ile-Pro-Pro changed the expression of glucocorticoid-synthesis driving transcription factor Lrh-1 expression or intestinal glucocorticoid production. Contrary to previous studies, captopril did not alleviate DSS-induced colitis. Furthermore, Ile-Pro-Pro was mildly pro-inflammatory as exhibited by increased pro-inflammatory cytokine interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) levels in colon. The nutritional component Ile-Pro-Pro had different effect on intestinal RAS and glucocorticoid (GC) synthesis pathway than ACE inhibitor captopril, which suggests that the bioactivity of Ile-Pro-Pro is not limited to inhibition of ACE. |
| المشرفين على المادة: | 0 (Angiotensin-Converting Enzyme Inhibitors) 0 (Interleukin-1beta) 0 (Interleukin-6) 0 (Oligopeptides) 0 (Tumor Necrosis Factor-alpha) 0 (interleukin-6, mouse) 0 (isoleucyl-prolyl-proline) 9042-14-2 (Dextran Sulfate) 9G64RSX1XD (Captopril) EC 1.14.14.1 (Cyp1b1 protein, mouse) EC 1.14.14.1 (Cytochrome P-450 CYP1B1) EC 3.4.15.1 (Peptidyl-Dipeptidase A) W980KJ009P (Corticosterone) |
| تواريخ الأحداث: | Date Created: 20170819 Date Completed: 20180509 Latest Revision: 20180509 |
| رمز التحديث: | 20240628 |
| PMID: | 28820392 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1899-1505 |
|---|