دورية أكاديمية
Regulation and Possible Functions of Kisspeptin in the Medial Amygdala.
العنوان: | Regulation and Possible Functions of Kisspeptin in the Medial Amygdala. |
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المؤلفون: | Stephens SBZ; Department of Reproductive Medicine, University of California, San Diego, La Jolla, CA, United States., Kauffman AS; Department of Reproductive Medicine, University of California, San Diego, La Jolla, CA, United States. |
المصدر: | Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2017 Aug 07; Vol. 8, pp. 191. Date of Electronic Publication: 2017 Aug 07 (Print Publication: 2017). |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Research Foundation] |
مستخلص: | Kisspeptin, encoded by the Kiss1 gene, is required for reproduction. Humans and mice lacking kisspeptin or its receptor, Kiss1r, have impairments in reproductive physiology and fertility. In addition to being located in the hypothalamus in the anteroventral periventricular and arcuate nuclei, kisspeptin neurons are also present in several extra-hypothalamic regions, such as the medial amygdala (MeA). However, while there has been a significant focus on the reproductive roles of hypothalamic kisspeptin neurons, the regulation and function(s) of MeA and other extra-hypothalamic kisspeptin neurons have received far less attention. This review summarizes what is currently known about the regulation, development, neural projections, and potential functions of MeA kisspeptin neurons, as well as kisspeptin signaling directly within the MeA, with emphasis on data gathered from rodent models. Recent data are summarized and compared between rodent species and also between males and females. In addition, critical gaps in knowledge and important future directions are discussed. |
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معلومات مُعتمدة: | F32 HD088060 United States HD NICHD NIH HHS; P50 HD012303 United States HD NICHD NIH HHS; R01 HD082567 United States HD NICHD NIH HHS; T32 HD007203 United States HD NICHD NIH HHS |
فهرسة مساهمة: | Keywords: GnRH; Kiss1; Kiss1r; LH; amygdala; kisspeptin; puberty; reproduction |
تواريخ الأحداث: | Date Created: 20170822 Latest Revision: 20191120 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC5545938 |
DOI: | 10.3389/fendo.2017.00191 |
PMID: | 28824550 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1664-2392 |
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DOI: | 10.3389/fendo.2017.00191 |