دورية أكاديمية
Clinical outcomes of patient-specific porous titanium endoprostheses in dogs with tumors of the mandible, radius, or tibia: 12 cases (2013-2016).
| العنوان: | Clinical outcomes of patient-specific porous titanium endoprostheses in dogs with tumors of the mandible, radius, or tibia: 12 cases (2013-2016). |
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| المؤلفون: | Bray JP, Kersley A, Downing W, Crosse KR, Worth AJ, House AK, Yates G, Coomer AR, Brown IWM |
| المصدر: | Journal of the American Veterinary Medical Association [J Am Vet Med Assoc] 2017 Sep 01; Vol. 251 (5), pp. 566-579. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Veterinary Medical Association Country of Publication: United States NLM ID: 7503067 Publication Model: Print Cited Medium: Internet ISSN: 1943-569X (Electronic) Linking ISSN: 00031488 NLM ISO Abbreviation: J Am Vet Med Assoc Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Mar. 1975- : Schaumburg, Ill. : American Veterinary Medical Association Original Publication: Ithaca, N.Y. : [American Veterinary Medical Association, 1915]- |
| مواضيع طبية MeSH: | Titanium*, Bone Neoplasms/*surgery , Dog Diseases/*surgery , Prosthesis Implantation/*veterinary, Animals ; Dogs ; Mandible ; Prospective Studies ; Prosthesis Design ; Radius ; Tibia ; Treatment Outcome |
| مستخلص: | OBJECTIVE To characterize the processes involved in and outcomes achieved with custom-designed patient-specific implants to provide functional replacement of skeletal structures in dogs with tumors of the mandible, radius, or tibia. DESIGN Prospective case series. ANIMALS 6 dogs with mandibular tumors, 5 with tumors of the distal aspect of the radius, and 1 with a tumor in the distal aspect of the tibia treated from June 2013 to September 2016 at 3 referral centers. PROCEDURES After tumor staging, implants were designed from patients' CT scans by means of various computer-aided design applications and printed by means of selective laser melting in titanium-6 aluminum-4 vanadium alloy. A cutting jig was created in thermoplastic to ensure each osteotomy was performed as planned. Following ostectomy, the implant was secured into the defect with screws of appropriate size and length. RESULTS Initial return to normal clinical function was good to excellent for 11 of the 12 dogs. However, major complications resulted in revision of the implant or amputation of the limb in 5 dogs, and at least 3 of these complications were considered a consequence of faulty implant design or manufacturing. Infection developed in 2 dogs and was successfully treated in 1 dog. The longest-surviving dog maintained good limb function for 2 years. CONCLUSIONS AND CLINICAL RELEVANCE This is the largest reported series of dogs managed with customized 3-D-printed titanium implants. The 3-D printing allowed complex and patient-specific 3-D geometries to be fabricated, enabling function-sparing treatment of bone cancer affecting multiple anatomic sites. |
| المشرفين على المادة: | D1JT611TNE (Titanium) |
| تواريخ الأحداث: | Date Created: 20170823 Date Completed: 20180102 Latest Revision: 20181202 |
| رمز التحديث: | 20221213 |
| DOI: | 10.2460/javma.251.5.566 |
| PMID: | 28828951 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1943-569X |
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| DOI: | 10.2460/javma.251.5.566 |