دورية أكاديمية
Assessment of exposure to pesticides in rural workers in southern of Minas Gerais, Brazil.
| العنوان: | Assessment of exposure to pesticides in rural workers in southern of Minas Gerais, Brazil. |
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| المؤلفون: | Silvério ACP; Laboratory of Toxicants and Drugs Analysis - LATF, Faculty of Pharmaceutical Sciences, Federal University of Alfenas - Unifal-MG, 700 Gabriel Monteiro da Silva street, 37130-000, Alfenas, MG, Brazil., Machado SC; Laboratory of Toxicants and Drugs Analysis - LATF, Faculty of Pharmaceutical Sciences, Federal University of Alfenas - Unifal-MG, 700 Gabriel Monteiro da Silva street, 37130-000, Alfenas, MG, Brazil., Azevedo L; Laboratory Nutritional and Toxicological Analysis in vivo - LANTIN, Faculty of Nutrion, Federal University of Alfenas - Unifal-MG, 700 Gabriel Monteiro da Silva street, 37130-000, Alfenas, MG, Brazil., Nogueira DA; Institute of Exact Sciences- ICEX- Federal University of Alfenas - Unifal-MG, 700 Gabriel Monteiro da Silva street, 37130-000, Alfenas, MG, Brazil., de Castro Graciano MM; Health department - DSA, Faculty of Medicine, Federal University of Lavras, 1001 Doctor Sylvio Menecucci, 37200-000, Lavras, MG, Brazil., Simões JS; Laboratory of Toxicants and Drugs Analysis - LATF, Faculty of Pharmaceutical Sciences, Federal University of Alfenas - Unifal-MG, 700 Gabriel Monteiro da Silva street, 37130-000, Alfenas, MG, Brazil., Viana ALM; Laboratory of Clinical Analysis- LACEN, Faculty of Pharmaceutical Sciences, Federal University of Alfenas - Unifal-MG, 700 Gabriel Monteiro da Silva street, 37130-000, Alfenas, MG, Brazil., Martins I; Laboratory of Toxicants and Drugs Analysis - LATF, Faculty of Pharmaceutical Sciences, Federal University of Alfenas - Unifal-MG, 700 Gabriel Monteiro da Silva street, 37130-000, Alfenas, MG, Brazil. Electronic address: isarita.sakakibara@unifal-mg.edu.br. |
| المصدر: | Environmental toxicology and pharmacology [Environ Toxicol Pharmacol] 2017 Oct; Vol. 55, pp. 99-106. Date of Electronic Publication: 2017 Aug 18. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science B.V Country of Publication: Netherlands NLM ID: 9612020 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7077 (Electronic) Linking ISSN: 13826689 NLM ISO Abbreviation: Environ Toxicol Pharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier Science B.V., c1996- |
| مواضيع طبية MeSH: | Alkanes/*analysis , Cholinesterases/*metabolism , Occupational Exposure/*adverse effects , Organophosphates/*adverse effects , Pesticides/*adverse effects, Adult ; Alkanes/blood ; Alkanes/urine ; Blood/drug effects ; Blood/metabolism ; Brazil ; DNA Damage ; Female ; Humans ; Male ; Micronucleus Tests ; Middle Aged ; Mouth/drug effects ; Mouth/metabolism ; Mutagenicity Tests ; Rural Population ; Urine/chemistry |
| مستخلص: | The aim of the study was to assess of occupational exposure to pesticides in rural workers using genotoxicity test, bioindicators and clinical evaluation. Blood, urine and buccal samples from persons, rural workers exposed to a complex mixture of pesticides with organophosphates (n=94) and without organophosphates (n=94) were collected to compare the activities of cholinesterases, the levels of urinary dialkyl phosphates, genotoxicity data, from a cytome assay. Biomarkers were analysed by traditional/published methods Control group consisted of 50 other persons, non- occupationally exposed to pesticides from the city of Alfenas, Minas Gerais, Brazil. All subjects underwent a clinical evaluation. In the group exposed to organophosphates, the activity of acetylcholinesterase, butyrylcholinesterase and total cholinesterase was lower by 63.8%, 12.8%, and 14.8%, respectively, and 92.6% of the group had dialkyl phosphates present in their urine. The cytome assay was used to measure biomarkers of DNA damage (micronuclei and/or elimination of nuclear material by budding), cytokinetic defects (binucleated cells), and proliferative potential (basal cell) and/or cell death (condensed chromatin, karyorrhectic, pyknotic, and karyolytic cells). The group exposed to organophosphates showed significant changes in all these parameters compared to the control group and showed significant changes in budding, condensed chromatin and karyolytic cells compared with the group non-exposed to organophosphates. Data from the clinical evaluation showed significant changes in the central nervous, respiratory and auditory systems. The studied biomarkers are able to distinguish occupational and environmental exposure to pesticides and the data showed hazardous exposure to organophosphates and afforded valuable data to estimate the risk to cancer development. (Copyright © 2017 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Cholinesterase activity; Clinical evaluation; Cytome assay; Occupational toxicology; Organophosphates; Urinary dialkyl phosphates |
| المشرفين على المادة: | 0 (Alkanes) 0 (Organophosphates) 0 (Pesticides) EC 3.1.1.8 (Cholinesterases) |
| تواريخ الأحداث: | Date Created: 20170827 Date Completed: 20180522 Latest Revision: 20180522 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.etap.2017.08.013 |
| PMID: | 28843102 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1872-7077 |
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| DOI: | 10.1016/j.etap.2017.08.013 |