دورية أكاديمية
أعرض في EDS

Integrated STAT3 and Ikaros Zinc Finger Transcription Factor Activities Regulate Bcl-6 Expression in CD4 + Th Cells.

التفاصيل البيبلوغرافية
العنوان: Integrated STAT3 and Ikaros Zinc Finger Transcription Factor Activities Regulate Bcl-6 Expression in CD4 + Th Cells.
المؤلفون: Read KA; Virginia Tech Carilion Research Institute, Roanoke, VA 24016., Powell MD; Virginia Tech Carilion Research Institute, Roanoke, VA 24016.; Graduate Program in Translational Biology, Medicine, and Health, Virginia Tech, Blacksburg, VA 24061., Baker CE; Virginia Tech Carilion Research Institute, Roanoke, VA 24016., Sreekumar BK; Virginia Tech Carilion Research Institute, Roanoke, VA 24016.; Graduate Program in Translational Biology, Medicine, and Health, Virginia Tech, Blacksburg, VA 24061., Ringel-Scaia VM; Graduate Program in Translational Biology, Medicine, and Health, Virginia Tech, Blacksburg, VA 24061.; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061., Bachus H; Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294; and., Martin RE; Virginia Tech Carilion Research Institute, Roanoke, VA 24016., Cooley ID; Virginia Tech Carilion Research Institute, Roanoke, VA 24016.; Virginia Tech Carilion School of Medicine, Roanoke, VA 24016., Allen IC; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061., Ballesteros-Tato A; Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294; and., Oestreich KJ; Virginia Tech Carilion Research Institute, Roanoke, VA 24016; oestrk@vtc.vt.edu.; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061.; Virginia Tech Carilion School of Medicine, Roanoke, VA 24016.
المصدر: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2017 Oct 01; Vol. 199 (7), pp. 2377-2387. Date of Electronic Publication: 2017 Aug 28.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: American Association of Immunologists Country of Publication: United States NLM ID: 2985117R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1550-6606 (Electronic) Linking ISSN: 00221767 NLM ISO Abbreviation: J Immunol Subsets: MEDLINE
أسماء مطبوعة: Publication: Bethesda, MD : American Association of Immunologists
Original Publication: Baltimore : Williams & Wilkins, c1950-
مواضيع طبية MeSH: CD4-Positive T-Lymphocytes/*immunology , CD4-Positive T-Lymphocytes/*metabolism , Ikaros Transcription Factor/*metabolism , Proto-Oncogene Proteins c-bcl-6/*genetics , STAT3 Transcription Factor/*metabolism, Animals ; Cell Differentiation ; Gene Expression Regulation ; Ikaros Transcription Factor/genetics ; Mice ; Orthomyxoviridae Infections/immunology ; Orthomyxoviridae Infections/virology ; Promoter Regions, Genetic ; Proto-Oncogene Proteins c-bcl-6/metabolism ; STAT3 Transcription Factor/genetics ; T-Lymphocytes, Helper-Inducer/metabolism ; Trans-Activators/genetics ; Trans-Activators/metabolism
مستخلص: B cell lymphoma-6 (Bcl-6) is a transcriptional repressor that is required for the differentiation of T follicular helper (T FH ) cell populations. Currently, the molecular mechanisms underlying the transcriptional regulation of Bcl-6 expression are unclear. In this study, we have identified the Ikaros zinc finger transcription factors Aiolos and Ikaros as novel regulators of Bcl-6. We found that increased expression of Bcl-6 in CD4 + Th cell populations correlated with enhanced enrichment of Aiolos and Ikaros at the Bcl6 promoter. Furthermore, overexpression of Aiolos or Ikaros, but not the related family member Eos, was sufficient to induce Bcl6 promoter activity. Intriguingly, STAT3, a known Bcl-6 transcriptional regulator, physically interacted with Aiolos to form a transcription factor complex capable of inducing the expression of Bcl6 and the T FH -associated cytokine receptor Il6ra Importantly, in vivo studies revealed that the expression of Aiolos was elevated in Ag-specific T FH cells compared with that observed in non-T FH effector Th cells generated in response to influenza infection. Collectively, these data describe a novel regulatory mechanism through which STAT3 and the Ikaros zinc finger transcription factors Aiolos and Ikaros cooperate to regulate Bcl-6 expression.
(Copyright © 2017 by The American Association of Immunologists, Inc.)
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معلومات مُعتمدة: P30 CA013148 United States CA NCI NIH HHS; R01 AI110480 United States AI NIAID NIH HHS; R03 DK105975 United States DK NIDDK NIH HHS; R56 AI127800 United States AI NIAID NIH HHS
المشرفين على المادة: 0 (Ikzf3 protein, mouse)
0 (Proto-Oncogene Proteins c-bcl-6)
0 (STAT3 Transcription Factor)
0 (Stat3 protein, mouse)
0 (Trans-Activators)
0 (Zfpn1a1 protein, mouse)
148971-36-2 (Ikaros Transcription Factor)
تواريخ الأحداث: Date Created: 20170830 Date Completed: 20171024 Latest Revision: 20210413
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC5657606
DOI: 10.4049/jimmunol.1700106
PMID: 28848064
قاعدة البيانات: MEDLINE
الوصف
تدمد:1550-6606
DOI:10.4049/jimmunol.1700106