دورية أكاديمية
Importance of Serum Testicular Protein Hormone Measurement in the Assessment of Disorders of Sex Development.
| العنوان: | Importance of Serum Testicular Protein Hormone Measurement in the Assessment of Disorders of Sex Development. |
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| المؤلفون: | Freire AV; Centro de Investigaciones Endocrinológicas 'Dr. César Bergadá' (CEDIE), CONICET - FEI - División de Endocrinología, Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina., Grinspon RP, Rey RA |
| المصدر: | Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation [Sex Dev] 2018; Vol. 12 (1-3), pp. 30-40. Date of Electronic Publication: 2017 Aug 30. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: S. Karger Country of Publication: Switzerland NLM ID: 101316472 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1661-5433 (Electronic) Linking ISSN: 16615425 NLM ISO Abbreviation: Sex Dev Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel ; New York : S. Karger, 2007- |
| مواضيع طبية MeSH: | Disorders of Sex Development/*blood , Disorders of Sex Development/*diagnosis , Testicular Hormones/*blood, Disorders of Sex Development/physiopathology ; Fetus/metabolism ; Humans ; Sex Differentiation |
| مستخلص: | Commonly known for testosterone secretion, the testes also produce the protein hormones anti-müllerian hormone (AMH), inhibin B, and insulin-like factor 3 (INSL3). AMH and inhibin B are secreted by Sertoli cells, whereas INSL3 is a Leydig cell product. AMH is involved in fetal sex differentiation and induces the regression of the anlagen of the uterus and fallopian tubes. INSL3 participates in fetal testicular descent. Serum testicular protein hormone assessment can be very useful and complementary to testosterone measurements in patients with DSD. AMH and inhibin B determination is extremely helpful during childhood, when basal testosterone is normally low. Serum AMH and inhibin B above the female range are indicative of the presence of testicular tissue, and their circulating levels reflect the amount of functional Sertoli cells. In DSD patients with normal male levels of AMH and inhibin B, the diagnosis of gonadal dysgenesis can be ruled out, and isolated androgen secretion deficiency or androgen insensitivity should be suspected. In externally virilized XY patients with persistent müllerian ducts, serum AMH levels determine the diagnosis to AMH deficiency or resistance. At pubertal age, inhibin B levels serve to predict spermatogenic development. (© 2017 S. Karger AG, Basel.) |
| فهرسة مساهمة: | Keywords: Anti-müllerian hormone; Inhibin B; Insulin-like factor 3; Leydig cells; Sertoli cells |
| المشرفين على المادة: | 0 (Testicular Hormones) |
| تواريخ الأحداث: | Date Created: 20170830 Date Completed: 20181116 Latest Revision: 20181116 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1159/000479572 |
| PMID: | 28850950 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1661-5433 |
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| DOI: | 10.1159/000479572 |