دورية أكاديمية
Genome-wide significant locus for Research Diagnostic Criteria Schizoaffective Disorder Bipolar type.
| العنوان: | Genome-wide significant locus for Research Diagnostic Criteria Schizoaffective Disorder Bipolar type. |
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| المؤلفون: | Green EK; School of Biomedical and Healthcare Sciences, Plymouth University Peninsula Schools of Medicine and Dentistry, Plymouth, UK., Di Florio A; MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Forty L; MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Gordon-Smith K; Department of Psychological Medicine, Worcester University, Worcester, UK., Grozeva D; Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK., Fraser C; MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Richards AL; MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Moran JL; Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Purcell S; Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Department of Psychiatry, Friedman Brain Institute, Icahn School of Medicine, Mount Sinai, New York.; Institute for Genomics and Multiscale Biology, Icahn School of Medicine, Mount Sinai, New York., Sklar P; Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Department of Psychiatry, Friedman Brain Institute, Icahn School of Medicine, Mount Sinai, New York.; Institute for Genomics and Multiscale Biology, Icahn School of Medicine, Mount Sinai, New York., Kirov G; MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Owen MJ; MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., O'Donovan MC; MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Craddock N; MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Jones L; Department of Psychological Medicine, Worcester University, Worcester, UK., Jones IR; MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK. |
| المصدر: | American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics [Am J Med Genet B Neuropsychiatr Genet] 2017 Dec; Vol. 174 (8), pp. 767-771. Date of Electronic Publication: 2017 Aug 29. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 101235742 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-485X (Electronic) Linking ISSN: 15524841 NLM ISO Abbreviation: Am J Med Genet B Neuropsychiatr Genet Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Hoboken, N.J. : Wiley-Blackwell Original Publication: Hoboken, N.J. : Wiley-Liss, c2003- |
| مواضيع طبية MeSH: | Genetic Markers* , Genome-Wide Association Study* , Polymorphism, Single Nucleotide*, Bipolar Disorder/*diagnosis , Schizophrenia/*diagnosis, Bipolar Disorder/genetics ; Case-Control Studies ; Genetic Predisposition to Disease ; Humans ; Meta-Analysis as Topic ; Schizophrenia/genetics |
| مستخلص: | Studies have suggested that Research Diagnostic Criteria for Schizoaffective Disorder Bipolar type (RDC-SABP) might identify a more genetically homogenous subgroup of bipolar disorder. Aiming to identify loci associated with RDC-SABP, we have performed a replication study using independent RDC-SABP cases (n = 144) and controls (n = 6,559), focusing on the 10 loci that reached a p-value <10 -5 for RDC-SABP in the Wellcome Trust Case Control Consortium (WTCCC) bipolar disorder sample. Combining the WTCCC and replication datasets by meta-analysis (combined RDC-SABP, n = 423, controls, n = 9,494), we observed genome-wide significant association at one SNP, rs2352974, located within the intron of the gene TRAIP on chromosome 3p21.31 (p-value, 4.37 × 10 -8 ). This locus did not reach genome-wide significance in bipolar disorder or schizophrenia large Psychiatric Genomic Consortium datasets, suggesting that it may represent a relatively specific genetic risk for the bipolar subtype of schizoaffective disorder. (© 2017 Wiley Periodicals, Inc.) |
| معلومات مُعتمدة: | 078901 United Kingdom WT_ Wellcome Trust; MR/L010305/1 United Kingdom MRC_ Medical Research Council; MR/P005748/1 United Kingdom MRC_ Medical Research Council |
| فهرسة مساهمة: | Keywords: Research Diagnostic Criteria; SABP; TRAIP; schizoaffective disorder bipolar type |
| المشرفين على المادة: | 0 (Genetic Markers) |
| تواريخ الأحداث: | Date Created: 20170830 Date Completed: 20180216 Latest Revision: 20220129 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1002/ajmg.b.32572 |
| PMID: | 28851079 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1552-485X |
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| DOI: | 10.1002/ajmg.b.32572 |