دورية أكاديمية
Regulation of Orai1/STIM1 mediated I CRAC by intracellular pH.
العنوان: | Regulation of Orai1/STIM1 mediated I |
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المؤلفون: | Gavriliouk D; School of Medical Sciences, University of Adelaide, Adelaide, South Australia, 5005, Australia., Scrimgeour NR; School of Medical Sciences, University of Adelaide, Adelaide, South Australia, 5005, Australia., Grigoryev S; School of Medicine, University of Adelaide, and South Australian Health and Medical Research Institute, Adelaide, South Australia, 5005, Australia., Ma L; School of Medical Sciences, University of Adelaide, Adelaide, South Australia, 5005, Australia.; Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia., Zhou FH; School of Medicine, University of Adelaide, and South Australian Health and Medical Research Institute, Adelaide, South Australia, 5005, Australia., Barritt GJ; School of Medicine, Flinders University of South Australia, Bedford Park, South Australia, 5065, Australia., Rychkov GY; School of Medical Sciences, University of Adelaide, Adelaide, South Australia, 5005, Australia. Grigori.Rychkov@adelaide.edu.au.; School of Medicine, University of Adelaide, and South Australian Health and Medical Research Institute, Adelaide, South Australia, 5005, Australia. Grigori.Rychkov@adelaide.edu.au. |
المصدر: | Scientific reports [Sci Rep] 2017 Aug 29; Vol. 7 (1), pp. 9829. Date of Electronic Publication: 2017 Aug 29. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: London : Nature Publishing Group, copyright 2011- |
مواضيع طبية MeSH: | Gene Expression Regulation* , Hydrogen-Ion Concentration*, Calcium Release Activated Calcium Channels/*metabolism , Neoplasm Proteins/*genetics , ORAI1 Protein/*genetics , Stromal Interaction Molecule 1/*genetics, Calcium/metabolism ; Cell Line ; Humans ; Intracellular Space/metabolism ; Ion Channel Gating ; Mutation ; Neoplasm Proteins/metabolism ; ORAI1 Protein/metabolism ; Stromal Interaction Molecule 1/metabolism |
مستخلص: | Ca 2+ release activated Ca 2+ (CRAC) channels composed of two cellular proteins, Ca 2+ -sensing stromal interaction molecule 1 (STIM1) and pore-forming Orai1, are the main mediators of the Ca 2+ entry pathway activated in response to depletion of intracellular Ca 2+ stores. Previously it has been shown that the amplitude of CRAC current (I |
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المشرفين على المادة: | 0 (Calcium Release Activated Calcium Channels) 0 (Neoplasm Proteins) 0 (ORAI1 Protein) 0 (ORAI1 protein, human) 0 (STIM1 protein, human) 0 (Stromal Interaction Molecule 1) SY7Q814VUP (Calcium) |
تواريخ الأحداث: | Date Created: 20170831 Date Completed: 20190423 Latest Revision: 20190423 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC5575016 |
DOI: | 10.1038/s41598-017-06371-0 |
PMID: | 28851859 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2045-2322 |
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DOI: | 10.1038/s41598-017-06371-0 |