دورية أكاديمية
N-glycosylation of the transient receptor potential melastatin 8 channel is altered in pancreatic cancer cells.
| العنوان: | N-glycosylation of the transient receptor potential melastatin 8 channel is altered in pancreatic cancer cells. |
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| المؤلفون: | Ulăreanu R; 1 Department of Anatomy, Animal Physiology and Biophysics, Faculty of Biology, University of Bucharest, Bucharest, Romania., Chiriţoiu G; 2 Department of Molecular Cell Biology, Institute of Biochemistry, Romanian Academy, Bucharest, Romania., Cojocaru F; 1 Department of Anatomy, Animal Physiology and Biophysics, Faculty of Biology, University of Bucharest, Bucharest, Romania., Deftu A; 1 Department of Anatomy, Animal Physiology and Biophysics, Faculty of Biology, University of Bucharest, Bucharest, Romania., Ristoiu V; 1 Department of Anatomy, Animal Physiology and Biophysics, Faculty of Biology, University of Bucharest, Bucharest, Romania., Stănică L; 1 Department of Anatomy, Animal Physiology and Biophysics, Faculty of Biology, University of Bucharest, Bucharest, Romania., Mihăilescu DF; 1 Department of Anatomy, Animal Physiology and Biophysics, Faculty of Biology, University of Bucharest, Bucharest, Romania., Cucu D; 1 Department of Anatomy, Animal Physiology and Biophysics, Faculty of Biology, University of Bucharest, Bucharest, Romania. |
| المصدر: | Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine [Tumour Biol] 2017 Aug; Vol. 39 (8), pp. 1010428317720940. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: IOS Press Country of Publication: Netherlands NLM ID: 8409922 Publication Model: Print Cited Medium: Internet ISSN: 1423-0380 (Electronic) Linking ISSN: 10104283 NLM ISO Abbreviation: Tumour Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2021- : Amsterdam, The Netherlands : IOS Press Original Publication: Tokyo, Japan : Saikon Pub. Co., c1984- |
| مواضيع طبية MeSH: | Carcinogenesis/*genetics , Carcinoma, Pancreatic Ductal/*genetics , Pancreatic Neoplasms/*genetics , TRPM Cation Channels/*genetics, Calcium/metabolism ; Carcinoma, Pancreatic Ductal/pathology ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Epithelial Cells/metabolism ; Gene Expression Regulation, Neoplastic ; Glycosylation ; Humans ; Pancreas ; Pancreatic Neoplasms/pathology ; Patch-Clamp Techniques |
| مستخلص: | Transient receptor potential melastatin 8 (TRPM8), a membrane ion channel, is activated by thermal and chemical stimuli. In pancreatic ductal adenocarcinoma, TRPM8 is required for cell migration, proliferation, and senescence and is associated with tumor size and pancreatic ductal adenocarcinoma stages. Although the underlying mechanisms of these processes have yet to be described, this cation-permeable channel has been proposed as an oncological target. In this study, the glycosylation status of the TRPM8 channel was shown to affect cell proliferation, cell migration, and calcium uptake. TRPM8 expressed in the membrane of the Panc-1 pancreatic tumoral cell line is non-glycosylated, whereas human embryonic kidney cells transfected with human TRPM8 overexpress a glycosylated protein. Moreover, our data suggest that Ca 2+ uptake is modulated by the glycosylation status of the protein, thus affecting cell proliferation. |
| فهرسة مساهمة: | Keywords: Pancreatic cancer; cell migration; glycosylation; membrane protein; patch clamp; transient receptor potential melastatin 8 |
| المشرفين على المادة: | 0 (TRPM Cation Channels) 0 (TRPM8 protein, human) SY7Q814VUP (Calcium) |
| تواريخ الأحداث: | Date Created: 20170901 Date Completed: 20170908 Latest Revision: 20170908 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1177/1010428317720940 |
| PMID: | 28857015 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1423-0380 |
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| DOI: | 10.1177/1010428317720940 |