Monomeric and Dimeric Oxidomolybdenum(V and VI) Complexes, Cytotoxicity, and DNA Interaction Studies: Molybdenum Assisted C═N Bond Cleavage of Salophen Ligands.

التفاصيل البيبلوغرافية
العنوان:	Monomeric and Dimeric Oxidomolybdenum(V and VI) Complexes, Cytotoxicity, and DNA Interaction Studies: Molybdenum Assisted C═N Bond Cleavage of Salophen Ligands.
المؤلفون:	Majumder S; Department of Chemistry, National Institute of Technology , Rourkela 769008, Odisha, India., Pasayat S; Department of Chemistry, National Institute of Technology , Rourkela 769008, Odisha, India., Panda AK; School of Basic Sciences, Indian Institute of Technology Bhubaneswar , Bhubaneswar 751013, Odisha, India., Dash SP; Department of Chemistry, National Institute of Technology , Rourkela 769008, Odisha, India.; Department of Basic Sciences, Paralamaharaja Engineering College , Sitalapalli, Brahmapur, Odisha 761003, India., Roy S; Department of Chemistry, National Institute of Technology , Rourkela 769008, Odisha, India., Biswas A; School of Basic Sciences, Indian Institute of Technology Bhubaneswar , Bhubaneswar 751013, Odisha, India., Varma ME; Bioprospecting Group, Agharkar Research Institute , G.G. Agharkar Road, Pune 411004, India., Joshi BN; Bioprospecting Group, Agharkar Research Institute , G.G. Agharkar Road, Pune 411004, India., Garribba E; Dipartimento di Chimica e Farmacia, Università di Sassari , Via Vienna 2, I-07100 Sassari, Italy., Kausar C; Department of Life Science, National Institute of Technology , Rourkela 769008, Odisha, India., Patra SK; Department of Life Science, National Institute of Technology , Rourkela 769008, Odisha, India., Kaminsky W; Department of Chemistry, University of Washington , Box 351700, Seattle, Washington 98195, United States., Crochet A; Department of Chemistry, Fribourg Center for Nanomaterials, University of Fribourg , CH-1700 Fribourg, Switzerland., Dinda R; Department of Chemistry, National Institute of Technology , Rourkela 769008, Odisha, India.
المصدر:	Inorganic chemistry [Inorg Chem] 2017 Sep 18; Vol. 56 (18), pp. 11190-11210. Date of Electronic Publication: 2017 Aug 31.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: American Chemical Society Country of Publication: United States NLM ID: 0366543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-510X (Electronic) Linking ISSN: 00201669 NLM ISO Abbreviation: Inorg Chem Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: [Easton, Pa.] American Chemical Society.
مواضيع طبية MeSH:	Antineoplastic Agents/pharmacology , Coordination Complexes/pharmacology , DNA/drug effects , Molybdenum/pharmacology , Oxides/pharmacology , Salicylates/pharmacology, Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cattle ; Cell Death/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Coordination Complexes/chemical synthesis ; Coordination Complexes/chemistry ; Crystallography, X-Ray ; DNA/chemistry ; Drug Screening Assays, Antitumor ; Humans ; Ligands ; MCF-7 Cells ; Models, Molecular ; Molecular Structure ; Molybdenum/chemistry ; Oxides/chemistry ; Salicylates/chemistry
مستخلص:	Four novel dimeric bis-μ-imido bridged metal-metal bonded oxidomolybdenum(V) complexes [Mo ^V 2 O 2 L' 2 ^1-4 ] (1-4) (where L' ^1-4 are rearranged ligands formed in situ from H 2 L ^1-4 ) and a new mononuclear dioxidomolybdenum(VI) complex [Mo ^VI O 2 L ⁵ ] (5) synthesized from salen type N 2 O 2 ligands are reported. This rare series of imido-bridged complexes (1-4) have been furnished from rearranged H 3 L' ^1-4 ligands, containing an aromatic diimine (o-phenylenediamine) "linker", where Mo assisted hydrolysis followed by -C═N bond cleavage of one of the arms of the ligand H 2 L ^1-4 took place. A monomeric molybdenum(V) intermediate species [Mo ^V O(HL' ^1-4 )(OEt)] (I d ^1-4 ) was generated in situ. The concomitant deprotonation and dimerization of two molybdenum(V) intermediate species (I d ^1-4 ) ultimately resulted in the formation of a bis-μ-imido bridge between the two molybdenum centers of [Mo ^V 2 O 2 L' 2 ^1-4 ] (1-4). The mechanism of formation of 1-4 has been discussed, and one of the rare intermediate monomeric molybdenum(V) species I d ⁴ has been isolated in the solid state and characterized. The monomeric dioxidomolybdenum(VI) complex [Mo ^VI O 2 L ⁵ ] (5) was prepared from the ligand H 2 L ⁵ where the aromatic "linker" was replaced by an aliphatic diimine (1,2-diaminopropane). All the ligands and complexes have been characterized by elemental analysis, IR, UV-vis spectroscopy, NMR, ESI-MS, and cyclic voltammetry, and the structural features of 1, 2, 4, and 5 have been solved by X-ray crystallography. The DNA binding and cleavage activity of 1-5 have been explored. The complexes interact with CT-DNA by the groove binding mode, and the binding constants range between 10 ³ and 10 ⁴ M ^-1 . Fairly good photoinduced cleavage of pUC19 supercoiled plasmid DNA was exhibited by all the complexes, with 4 showing the most promising photoinduced DNA cleavage activity of ∼93%. Moreover, in vitro cytotoxic activity of all the complexes was evaluated by MTT assay, which reveals that the complexes induce cell death in MCF-7 (human breast adenocarcinoma) and HCT-15 (colon cancer) cell lines.
المشرفين على المادة:	0 (Antineoplastic Agents) 0 (Coordination Complexes) 0 (Ligands) 0 (Oxides) 0 (Salicylates) 118-57-0 (salophen) 81AH48963U (Molybdenum) 9007-49-2 (DNA) 91080-16-9 (calf thymus DNA)
تواريخ الأحداث:	Date Created: 20170901 Date Completed: 20180307 Latest Revision: 20180307
رمز التحديث:	20221213
DOI:	10.1021/acs.inorgchem.7b01578
PMID:	28858483
قاعدة البيانات:	MEDLINE

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الوصف
تدمد:	1520-510X
DOI:	10.1021/acs.inorgchem.7b01578