دورية أكاديمية
Dexamethasone impairs encoding and expression of aversive conditioning promoted by pentylenetetrazole.
العنوان: | Dexamethasone impairs encoding and expression of aversive conditioning promoted by pentylenetetrazole. |
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المؤلفون: | Cavalli J; Department of Pharmacology, Biological Sciences Center, Federal University of Santa Catarina, Florianópolis., Hoeller AA; Department of Pharmacology, Biological Sciences Center, Federal University of Santa Catarina, Florianópolis., Dal Bó S; Academic Unity of Health Sciences, University of Extremo Sul Catarinense, Criciúma, Brazil., Bertoglio LJ; Department of Pharmacology, Biological Sciences Center, Federal University of Santa Catarina, Florianópolis., de Lima TCM; Department of Pharmacology, Biological Sciences Center, Federal University of Santa Catarina, Florianópolis., Carobrez AP; Department of Pharmacology, Biological Sciences Center, Federal University of Santa Catarina, Florianópolis. |
المصدر: | Behavioural pharmacology [Behav Pharmacol] 2020 Aug; Vol. 31 (5), pp. 435-447. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Lippincott Williams and Wilkins Country of Publication: England NLM ID: 9013016 Publication Model: Print Cited Medium: Internet ISSN: 1473-5849 (Electronic) Linking ISSN: 09558810 NLM ISO Abbreviation: Behav Pharmacol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: London : Lippincott Williams and Wilkins Original Publication: London : Clinical Neuroscience Publishers, |
مواضيع طبية MeSH: | Conditioning, Psychological/*drug effects , Dexamethasone/*pharmacology , Fear/*psychology , Memory/*drug effects , Memory Consolidation/*drug effects, Animals ; Male ; Pentylenetetrazole ; Rats |
مستخلص: | Behavioral and neuroendocrine responses following threatening situations promote the release of corticosterone, which is known to modulate trauma-related learning and memory process. However, it remains unknown whether the aversive learning generated by interoceptive fear conditioning is affected by glucocorticoid modulation. Therefore, the present study aimed to investigate the role of dexamethasone suppression in encoding and expression of pentylenetetrazole-induced olfactory fear conditioning (OFC) and in contextual second-order conditioning promoted by the conditioned odor. Adult male Long-Evans rats were treated with dexamethasone 60 min before the encoding or the expression in both OFC and contextual second-order conditioning. Dexamethasone treatment impaired encoding and expression of the OFC, but failed to impair encoding and expression of the contextual second-order conditioning. Altogether, our results show that although OFC and thereafter contextual second-order conditioning may allow the study of traumatic memories, each order of conditioning seems to present specific features related to their pharmacological modulation. These findings highlight the importance of addressing the role of neuromodulatory systems in first-order and second-order conditioning to gain a better understanding of these phenomena and support future therapies related to traumatic memories. |
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المشرفين على المادة: | 7S5I7G3JQL (Dexamethasone) WM5Z385K7T (Pentylenetetrazole) |
تواريخ الأحداث: | Date Created: 20170902 Date Completed: 20210201 Latest Revision: 20210202 |
رمز التحديث: | 20231215 |
DOI: | 10.1097/FBP.0000000000000344 |
PMID: | 28863004 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1473-5849 |
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DOI: | 10.1097/FBP.0000000000000344 |