دورية أكاديمية
أعرض في EDS

Dexamethasone impairs encoding and expression of aversive conditioning promoted by pentylenetetrazole.

التفاصيل البيبلوغرافية
العنوان: Dexamethasone impairs encoding and expression of aversive conditioning promoted by pentylenetetrazole.
المؤلفون: Cavalli J; Department of Pharmacology, Biological Sciences Center, Federal University of Santa Catarina, Florianópolis., Hoeller AA; Department of Pharmacology, Biological Sciences Center, Federal University of Santa Catarina, Florianópolis., Dal Bó S; Academic Unity of Health Sciences, University of Extremo Sul Catarinense, Criciúma, Brazil., Bertoglio LJ; Department of Pharmacology, Biological Sciences Center, Federal University of Santa Catarina, Florianópolis., de Lima TCM; Department of Pharmacology, Biological Sciences Center, Federal University of Santa Catarina, Florianópolis., Carobrez AP; Department of Pharmacology, Biological Sciences Center, Federal University of Santa Catarina, Florianópolis.
المصدر: Behavioural pharmacology [Behav Pharmacol] 2020 Aug; Vol. 31 (5), pp. 435-447.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams and Wilkins Country of Publication: England NLM ID: 9013016 Publication Model: Print Cited Medium: Internet ISSN: 1473-5849 (Electronic) Linking ISSN: 09558810 NLM ISO Abbreviation: Behav Pharmacol Subsets: MEDLINE
أسماء مطبوعة: Publication: London : Lippincott Williams and Wilkins
Original Publication: London : Clinical Neuroscience Publishers,
مواضيع طبية MeSH: Conditioning, Psychological/*drug effects , Dexamethasone/*pharmacology , Fear/*psychology , Memory/*drug effects , Memory Consolidation/*drug effects, Animals ; Male ; Pentylenetetrazole ; Rats
مستخلص: Behavioral and neuroendocrine responses following threatening situations promote the release of corticosterone, which is known to modulate trauma-related learning and memory process. However, it remains unknown whether the aversive learning generated by interoceptive fear conditioning is affected by glucocorticoid modulation. Therefore, the present study aimed to investigate the role of dexamethasone suppression in encoding and expression of pentylenetetrazole-induced olfactory fear conditioning (OFC) and in contextual second-order conditioning promoted by the conditioned odor. Adult male Long-Evans rats were treated with dexamethasone 60 min before the encoding or the expression in both OFC and contextual second-order conditioning. Dexamethasone treatment impaired encoding and expression of the OFC, but failed to impair encoding and expression of the contextual second-order conditioning. Altogether, our results show that although OFC and thereafter contextual second-order conditioning may allow the study of traumatic memories, each order of conditioning seems to present specific features related to their pharmacological modulation. These findings highlight the importance of addressing the role of neuromodulatory systems in first-order and second-order conditioning to gain a better understanding of these phenomena and support future therapies related to traumatic memories.
References: Almeida-Souza TH, Goes TC, Teixeira-Silva F. Pharmacological validation of the free-exploratory paradigm in male Wistar rats: a proposed test of trait anxiety. Pharmacol Biochem Behav. 2015; 135:114–120.
Arp JM, Ter Horst JP, Loi M, den Blaauwen J, Bangert E, Fernández G, et al. Blocking glucocorticoid receptors at adolescent age prevents enhanced freezing between repeated cue-exposures after conditioned fear in adult mice raised under chronic early life stress. Neurobiol Learn Mem. 2016; 133:30–38.
Badiani A, Jakob A, Rodaros D, Stewart J. Sensitization of stress-induced feeding in rats repeatedly exposed to brief restraint: the role of corticosterone. Brain Res. 1996; 26:35–44.
Baldi E, Bucherelli C. Brain sites involved in fear memory reconsolidation and extinction of rodents. Neurosci Biobehav Rev. 2015; 53:160–190.
Bhattacharya SS, Kishor K, Saxena PN, Bhargava KP. A neuropharmacological study of gamma-aminobutyric acid (GABA). Arch Int Pharmacodyn Ther. 1964; 150:295–305.
Blanchard DC, Blanchard RJ, Griebel G. Defensive responses to predator threat in the rat and mouse. Curr Protoc Neurosci. 200510.1002/0471142301.ns0819s30. (PMID: 10.1002/0471142301.ns0819s30)
Broersen LM. Attentional processes and learning and memory in rats: the prefrontal cortex and hippocampus compared. Prog Brain Res. 2000; 126:79–94.
Broersen LM, Abbate F, Feenstra MG, de Bruin JP, Heinsbroek RP, Olivier B. Prefrontal dopamine is directly involved in the anxiogenic interoceptive cue of pentylenetetrazol but not in the interoceptive cue of chlordiazepoxide in the rat. Psychopharmacology (Berl). 2000; 149:366–376.
Cacciaglia R, Pohlack ST, Flor H, Nees F. Dissociable roles for hippocampal and amygdalar volume in human fear conditioning. Brain Struct Funct. 2015; 220:2575–2586.
Campeau S, Davis M. Involvement of the central nucleus and basolateral complex of the amygdala in fear conditioning measured with fear-potentiated startle in rats trained concurrently with auditory and visual conditioned stimuli. J Neurosci. 1995; 15:2301–2311.
Carobrez AP, Bertoglio LJ. Ethological and temporal analyses of anxiety-like behavior: the elevated plus-maze model 20 years on. Neurosci Biobehav Rev. 2005; 29:1193–1205.
Carroll BJ, Martin FIR, Davies B. Resistance to suppression by DEX of Plasma 11-Ohcs levels in severe depressive illness. Br Med J. 1968; 3:285–287.
Cavalli J, Bertoglio LJ, Carobrez AP. Pentylenetetrazole as an unconditioned stimulus for olfactory and contextual fear conditioning in rats. Neurobiol Learn Mem. 2009; 92:512–518.
Choudhury-Peters D, Tahim A, Davies A, Bhatti N. Model of collaborative care for post-traumatic stress disorder in patients and carers. Br J Oral Maxillofac Surg. 2016; 55:443–444.
Cook M, Mineka S. Second-order conditioning and overshadowing in the observational conditioning of fear in monkeys. Behav Res Ther. 1987; 25:349–364.
Debiec J, Ledoux JE. Disruption of reconsolidation but not consolidation of auditory fear conditioning by noradrenergic blockade in the amygdala. Neuroscience. 2004; 129:267–272.
De Kloet ER. From receptor balance to rational glucocorticoid therapy. Endocrinology. 2014; 155:2754–2769.
De Kloet ER, van der Vies J, de Wied D. The site of the suppressive action of dexamethasone on pituitary–adrenal activity. Endocrinology. 1974; 94:61–73.
De Kloet R, Wallach G, McEwen BS. Differences in corticosterone and dexamethasone binding to rat brain and pituitary. Endocrinology. 1975; 96:598–609.
De Kloet ER, Oitzl MS, Joëls M. Stress and cognition: are corticosteroids good or bad guys? Trends Neurosci. 1999; 22:422–426.
De Kloet ER, Joëls M, Holsboer F. Stress and the brain: from adaptation to disease. Nat Rev Neurosci. 2005; 6:463–475.
De Quervain DJ, Roozendaal B, Mcgaugh JL. Stress and glucocorticoids impair retrieval of long-term spatial memory. Nature. 1998; 394:787–790.
De Quervain DJ, Aerni A, Schelling G, Roozendaal B. Glucocorticoids and the regulation of memory in health and disease. Front Neuroendocrinol. 2009; 30:358–370.
De Souza MM, Schenberg LC, Carobrez AP. NMDA-coupled periaqueductal gray glycine receptors modulate anxioselective drug effects on plus-maze performance. Behav Brain Res. 1998; 90:157–165.
Diamond DM, Fleshner M, Ingersoll N, Rose GM. Psychological stress impairs spatial working memory: relevance to electrophysiological studies of hippocampal function. Behav Neurosci. 1996; 110:661–672.
Favrole P, Jehel L, Levy P, Descombes S, Muresan IP, Manifacier MJ, et al. Frequency and predictors of post-traumatic stress disorder after stroke: a pilot study. J Neurol Sci. 2013; 327:35–40.
Fernandez F, Morishita W, Zuniga E, Ngyen J, Blank M, Malenka RC, et al. Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome. Nature Neurosci. 2007; 10:411–413.
File S, Curle PF, Baldwin HA, Neal MJ. Anxiety in the rat is associate with decrease release of 5-HT and glycine from hippocampus. Neurosci Lett. 1987; 29:318–322.
Fluttert M, Dalm S, Oitzl MS. A refined method for sequential blood sampling by tail incision in rats. Lab Anim. 2000; 34:372–378.
Garcia MJ, Williams J, Sinderman B, Earley RL. Ready for a fight? The physiological effects of detecting an opponent’s pheromone cues prior to a contest. Physiol Behav. 2015; 1:1–7.
Gewirtz JC, Davis M. Using Pavlovian higher-order conditioning paradigms to investigate the neural substrates of emotional learning and memory. Learn Mem. 2000; 7:257–266.
Gilboa A, Sekeres M, Moscovitch M, Winocur G. Higher-order conditioning is impaired by hippocampal lesions. Curr Biol. 2014; 22:2202–2207.
Heim C, Nemeroff CB. Neurobiology of posttraumatic stress disorder. CNS Spectr. 2009; 14Suppl 113–24.
Hoeller AA, Duzzioni M, Duarte FS, Leme LR, Costa AP, Santos EC, et al. GABA-A receptor modulators alter emotionality and hippocampal theta rhythm in an animal model of long-lasting anxiety. Brain Res. 2013; 26:21–31.
Jaggi AS, Bhatia N, Kumar N, Singh N, Anand P, Dhawan R. A review on animal models for screening potential anti-stress agents. Neurol Sci. 2011; 32:993–1005.
Jung ME, Lal H, Gatch MB. The discriminative stimulus effects of pentylenetetrazole as a model of anxiety: recent developments. Neurosci Biobehav Rev. 2002; 26:429–439.
Kilpatrick L, Cahill L. Modulation of memory consolidation for olfactory learning by reversible inactivation of the basolateral amygdala. Behav Neurosci. 2003; 117:184–188.
Kim KN, Kim BT, Kim YS, Lee JH, Jahng JW. Increase of glucocorticoids is not required for the acquisition, but hinders the extinction, of lithium-induced conditioned taste aversion. Eur J Pharmacol. 2014; 5:14–19.
Kincheski GC, Mota-Ortiz SR, Pavesi E, Canteras NS, Carobrez AP. The dorsolateral periaqueductal gray and its role in mediating fear learning to life threatening events. PLoS One. 2012; 7:e50361.
Kirschbaum C, Wolf OT, May M, Wippich W, Hellhammer DH. Stress- and treatment-induced elevation of cortisol levels associated with impaired declarative memory in healthy adults. Life Sci. 1996; 58:1475–1483.
Kobayashi K, Oka M, Inoue T, Ogino T, Yoshinaga H, Ohtsuka Y. Characteristics of slow waves on EEG associated with epileptic spasms. Epilepsia. 2005; 46:1098–1105.
Krivanek J, McGaugh J. Effects of pentylenetetrazol on memory storage in mice. Psychopharmacologia. 1968; 12:303–321.
Kroon JA, Carobrez AP. Olfactory fear conditioning paradigm in rats: Effects of midazolam, propranolol or scopolamine. Neurobiol Learn Mem. 2009; 91:32–40.
Lal H, Emmett-Oglesby MW. Behavioral analogues of anxiety. Animal models. Neuropharmacology. 1983; 22:1423–1441.
LeDoux JE. Emotion circuits in the brain. Annu Rev Neurosci. 2000; 23:155–184.
Lindgren JL, Gallagher M, Holland PC. Lesions of basolateral amygdala impair extinction of CS motivational value, but not of explicit conditioned responses, in Pavlovian appetitive second-order conditioning. Eur J Neurosci. 2003; 17:160–166.
McEwen BS. Mood disorders and allostatic load. Biol Psychiatry. 2003; 54:200–207.
McEwen BS. Central effects of stress hormones in health and disease: understanding the protective and damaging effects of stress and stress mediators. Eur J Pharmacol. 2008; 583:174–185.
McNaughton N, Richardson J, Gore C. Reticular elicitation of hippocampal slow waves: common effects of some anxiolytic drugs. Neuroscience. 1986; 19:899–903.
Mizoguchi K, Ishige A, Takeda S, Aburada M, Tabira T. Endogenous glucocorticoids are essential for maintaining prefrontal cortical cognitive function. J Neurosci. 2004; 16:5492–5499.
O’Donnell D, Francis D, Weaver S, Meaney MJ. Effects of adrenalectomy and corticosterone replacement on glucocorticoid receptor levels in rat brain tissue: a comparison between western blotting and receptor binding assays. Brain Res. 1995; 687:133–142.
Osterman JE, Hopper J, Heran WJ, Keane TM, Van der Kolk BA. Awareness under anesthesia and the development of posttraumatic stress disorder. Gen Hosp Psychiatry. 2001; 23:198–204.
Parkes SL, Westbrook RF. The basolateral amygdala is critical for the acquisition and extinction of associations between a neutral stimulus and a learned danger signal but not between two neutral stimuli. J Neurosci. 2010; 22:12608–12618.
Paschall GY, Davis M. Olfactory-mediated fear-potentiated startle. Behav Neurosci. 2002; 116:4–12.
Pavesi E, Canteras NS, Carobrez AP. Acquisition of Pavlovian fear conditioning using β-adrenoceptor activation of the dorsal premammillary nucleus as an unconditioned stimulus to mimic live predator-threat exposure. Neuropsychopharmacology. 2011; 36:926–939.
Pugh CR, Tremblay D, Fleshner M, Rudy JW. A selective role for corticosterone in contextual-fear conditioning. Behav Neurosci. 1997; 111:503–511.
Rashidy-Pour A, Sadeghi H, Taherain AA, Vafaei AA, Fathollahi Y. The effects of acute restraint stress and dexamethasone on retrieval of long-term memory in rats: an interaction with opiate system. Behav Brain Res. 2004; 23:193–198.
Rodin E. Metrazol tolerance in a normal volunteer population: an investigation of the potential significance of abnormal findings. Electroencephalogr Clin Neurophysiol. 1958; 10:433–446.
Rueda N, Florez J, Martinez-Cue C. Chronic pentylenetetrazole but not denezepil treatment rescues spatial cognition in Ts65Dn mice, a model for Down syndrome. Neurosci Lett. 2008; 433:22–27.
Schelling G. Post-traumatic stress disorder in somatic disease: lessons from critically ill patients. Prog Brain Res. 2008; 167:229–237.
Schenberg LC, Bittencourt AS, Sudré EC, Vargas LC. Modeling panic attacks. Neurosci Biobehav Rev. 2001; 25:647–659.
Sejima H, Ito M, Kishi K, Tsuda H, Shiraishi H. Regional excitatory and inhibitory amino acid concentration in pentylenetetrazole kindling and kindled rat brain. Brain Dev. 1997; 19:171–175.
Shemesh E, Yehuda R, Milo O, Dinur I, Rudnick A, Vered Z, et al. Posttraumatic stress, nonadherence, and adverse outcome in survivors of a myocardial infarction. Psychosom Med. 2004; 66:521–526.
Souza RR, Dal Bó S, de Kloet ER, Oitzl MS, Carobrez AP. Paradoxical mineralocorticoid receptor-mediated effect in fear memory encoding and expression of rats submitted to an olfactory fear conditioning task. Neuropharmacology. 2014; 79:201–211.
Spanswick SC, Epp JR, Keith JR, Sutherland RJ. Adrenalectomy-induced granule cell degeneration in the hippocampus causes spatial memory deficits that are not reversed by chronic treatment with corticosterone or fluoxetine. Hippocampus. 2007; 17:137–146.
Spoont MR, Williams JW Jr, Kehle-Forbes S, Nieuwsma JA, Mann-Wrobel MC, Gross R. Does this patient have posttraumatic stress disorder? Rational clinical examination systematic review. JAMA. 2015; 4:501–510.
Suliman S, Ericksen T, Labuschgne P, de Wit R, Stein DJ, Seedat S. Comparison of pain, cortisol levels, and psychological distress in women undergoing surgical termination of pregnancy under local anaesthesia versus intravenous sedation. BMC Psychiatry. 2007; 7:24.
Terrazzino S, Perego C, De Simoni MG. Effect of development of habituation to restraint stress on hypothalamic noradrenaline release and adrenocorticotropin secretion. J Neurochem. 1995; 65:263–267.
Wong M, Wozniak DF, Yamada KA. An animal model of generalized nonconvulsive status epilepticus: immediate characteristics and long-term effects. Exp Neurol. 2003; 183:87–99.
المشرفين على المادة: 7S5I7G3JQL (Dexamethasone)
WM5Z385K7T (Pentylenetetrazole)
تواريخ الأحداث: Date Created: 20170902 Date Completed: 20210201 Latest Revision: 20210202
رمز التحديث: 20231215
DOI: 10.1097/FBP.0000000000000344
PMID: 28863004
قاعدة البيانات: MEDLINE
الوصف
تدمد:1473-5849
DOI:10.1097/FBP.0000000000000344