دورية أكاديمية
Drug repurposing strategy against Trypanosoma cruzi infection: In vitro and in vivo assessment of the activity of metronidazole in mono- and combined therapy.
العنوان: | Drug repurposing strategy against Trypanosoma cruzi infection: In vitro and in vivo assessment of the activity of metronidazole in mono- and combined therapy. |
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المؤلفون: | Simões-Silva MR; Laboratório de Biologia Celular do Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil., De Araújo JS; Laboratório de Biologia Celular do Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil., Oliveira GM; Laboratório de Biologia Celular do Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil., Demarque KC; Laboratório de Biologia Celular do Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil., Peres RB; Laboratório de Biologia Celular do Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil., D'Almeida-Melo I; Laboratório de Biologia Celular do Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil., Batista DGJ; Laboratório de Biologia Celular do Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil., Da Silva CF; Laboratório de Biologia Celular do Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil., Cardoso-Santos C; Laboratório de Biologia Celular do Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil., Da Silva PB; Laboratório de Biologia Celular do Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil., Batista MM; Laboratório de Biologia Celular do Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil., Bahia MT; Laboratório de Doenças Parasitárias, Escola de Medicina & Núcleo de Pesquisas em Ciências Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil., Soeiro MNC; Laboratório de Biologia Celular do Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address: soeiro@ioc.fiocruz.br. |
المصدر: | Biochemical pharmacology [Biochem Pharmacol] 2017 Dec 01; Vol. 145, pp. 46-53. Date of Electronic Publication: 2017 Sep 07. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Oxford : Elsevier Science Original Publication: Oxford, New York [etc.] Paragamon Press. |
مواضيع طبية MeSH: | Trypanosoma cruzi*, Antiprotozoal Agents/*pharmacology , Chagas Disease/*drug therapy , Metronidazole/*pharmacology , Myocytes, Cardiac/*parasitology , Nitroimidazoles/*pharmacology, Animals ; Antiprotozoal Agents/administration & dosage ; Antiprotozoal Agents/chemistry ; Antiprotozoal Agents/therapeutic use ; Cells, Cultured ; Drug Therapy, Combination ; Metronidazole/administration & dosage ; Metronidazole/chemistry ; Metronidazole/therapeutic use ; Mice ; Molecular Structure ; Myocytes, Cardiac/drug effects ; Nitroimidazoles/administration & dosage ; Nitroimidazoles/chemistry ; Nitroimidazoles/therapeutic use |
مستخلص: | Metronidazole (Mtz) is a commercial broad-spectrum nitroimidazolic derivative with relevant antimicrobial activity and relative safety profile. Therefore, it is fair to consider Mtz a candidate for drug repurposing for other neglected conditions such as Chagas disease (CD), a parasitic pathology caused by Trypanosoma cruzi. CD is treated only with benznidazole (Bz) and nifurtimox, both introduced in clinics decades ago despite important limitations, including low efficacy on the later disease stage (chronic form) and severe side effects. New cheap and fast alternative treatments for CD are needed, thus the repurposing of Mtz was assessed in vitro and in vivo in mono- and combined therapy. In vitro assays demonstrated EC (Copyright © 2017 Elsevier Inc. All rights reserved.) |
فهرسة مساهمة: | Keywords: Combined therapy; Drug repurposing; Metronidazole; Trypanosoma cruzi |
المشرفين على المادة: | 0 (Antiprotozoal Agents) 0 (Nitroimidazoles) 140QMO216E (Metronidazole) YC42NRJ1ZD (benzonidazole) |
تواريخ الأحداث: | Date Created: 20170906 Date Completed: 20171204 Latest Revision: 20180202 |
رمز التحديث: | 20221213 |
DOI: | 10.1016/j.bcp.2017.08.025 |
PMID: | 28870526 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1873-2968 |
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DOI: | 10.1016/j.bcp.2017.08.025 |