دورية أكاديمية
Astrocytic signaling supports hippocampal-prefrontal theta synchronization and cognitive function.
| العنوان: | Astrocytic signaling supports hippocampal-prefrontal theta synchronization and cognitive function. |
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| المؤلفون: | Sardinha VM; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, Braga 4710-057, Portugal.; ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal., Guerra-Gomes S; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, Braga 4710-057, Portugal.; ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal., Caetano I; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, Braga 4710-057, Portugal.; ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal., Tavares G; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, Braga 4710-057, Portugal.; ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal., Martins M; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, Braga 4710-057, Portugal.; ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal., Reis JS; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, Braga 4710-057, Portugal.; ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal., Correia JS; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, Braga 4710-057, Portugal.; ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal., Teixeira-Castro A; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, Braga 4710-057, Portugal.; ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal., Pinto L; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, Braga 4710-057, Portugal.; ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal., Sousa N; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, Braga 4710-057, Portugal.; ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal., Oliveira JF; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, Braga 4710-057, Portugal.; ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal.; DIGARC, Polytechnic Institute of Cávado and Ave, Barcelos 4750-810, Portugal. |
| المصدر: | Glia [Glia] 2017 Dec; Vol. 65 (12), pp. 1944-1960. Date of Electronic Publication: 2017 Sep 08. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8806785 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-1136 (Electronic) Linking ISSN: 08941491 NLM ISO Abbreviation: Glia Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York, NY : Wiley-Liss Original Publication: New York : Alan R. Liss, Inc., c1988- |
| مواضيع طبية MeSH: | Astrocytes/*metabolism , Cognition/*physiology , Hippocampus/*cytology , Prefrontal Cortex/*physiology , Signal Transduction/*physiology, Animals ; Astrocytes/pathology ; Astrocytes/ultrastructure ; Cognition Disorders/drug therapy ; Cognition Disorders/genetics ; Doxycycline/pharmacology ; Glial Fibrillary Acidic Protein/metabolism ; Glutamic Acid/metabolism ; Hippocampus/drug effects ; Hippocampus/physiology ; Maze Learning/physiology ; Mice ; Mice, Transgenic ; Models, Neurological ; Neurons/ultrastructure ; Prefrontal Cortex/cytology ; Prefrontal Cortex/drug effects ; Recognition, Psychology/physiology ; S100 Calcium Binding Protein beta Subunit/metabolism ; SNARE Proteins/genetics ; SNARE Proteins/metabolism ; Serine/pharmacology ; Spatial Behavior/physiology ; Theta Rhythm/drug effects ; Theta Rhythm/genetics |
| مستخلص: | Astrocytes interact with neurons at the cellular level through modulation of synaptic formation, maturation, and function, but the impact of such interaction into behavior remains unclear. Here, we studied the dominant negative SNARE (dnSNARE) mouse model to dissect the role of astrocyte-derived signaling in corticolimbic circuits, with implications for cognitive processing. We found that the blockade of gliotransmitter release in astrocytes triggers a critical desynchronization of neural theta oscillations between dorsal hippocampus and prefrontal cortex. Moreover, we found a strong cognitive impairment in tasks depending on this network. Importantly, the supplementation with d-serine completely restores hippocampal-prefrontal theta synchronization and rescues the spatial memory and long-term memory of dnSNARE mice. We provide here novel evidence of long distance network modulation by astrocytes, with direct implications to cognitive function. (© 2017 Wiley Periodicals, Inc.) |
| فهرسة مساهمة: | Keywords: astrocyte; behavior; local field potential; neuronal morphology; oscillations |
| المشرفين على المادة: | 0 (Glial Fibrillary Acidic Protein) 0 (S100 Calcium Binding Protein beta Subunit) 0 (SNARE Proteins) 3KX376GY7L (Glutamic Acid) 452VLY9402 (Serine) N12000U13O (Doxycycline) |
| تواريخ الأحداث: | Date Created: 20170909 Date Completed: 20180605 Latest Revision: 20220330 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1002/glia.23205 |
| PMID: | 28885722 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1098-1136 |
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| DOI: | 10.1002/glia.23205 |