دورية أكاديمية
أعرض في EDS

Probiotic Supplementation in Chronic Kidney Disease: A Double-blind, Randomized, Placebo-controlled Trial.

التفاصيل البيبلوغرافية
العنوان: Probiotic Supplementation in Chronic Kidney Disease: A Double-blind, Randomized, Placebo-controlled Trial.
المؤلفون: Borges NA; Graduate Program in Cardiovascular Sciences, Fluminense Federal University (UFF), Niterói-RJ, Brazil; Medical Sciences Graduate Program, Federal University Fluminense (UFF), Niterói-RJ, Brazil. Electronic address: nat_borges_@hotmail.com., Carmo FL; Institute of Microbiology, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil., Stockler-Pinto MB; Graduate Program in Cardiovascular Sciences, Fluminense Federal University (UFF), Niterói-RJ, Brazil., de Brito JS; Graduate Program in Cardiovascular Sciences, Fluminense Federal University (UFF), Niterói-RJ, Brazil., Dolenga CJ; Basic Pathology Department, Federal University of Paraná (UFPR), Curitiba-PR, Brazil., Ferreira DC; Faculty of Dentistry, Veiga de Almeida University, Rio de Janeiro, Brazil., Nakao LS; Basic Pathology Department, Federal University of Paraná (UFPR), Curitiba-PR, Brazil., Rosado A; Institute of Microbiology, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil., Fouque D; Department of Nephrology, Centre Hospitalier Lyon Sud, Univ Lyon, UCBL, Inserm Carmen, CENS, F-69622 Lyon, France., Mafra D; Graduate Program in Cardiovascular Sciences, Fluminense Federal University (UFF), Niterói-RJ, Brazil; Medical Sciences Graduate Program, Federal University Fluminense (UFF), Niterói-RJ, Brazil.
المصدر: Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation [J Ren Nutr] 2018 Jan; Vol. 28 (1), pp. 28-36. Date of Electronic Publication: 2017 Sep 06.
نوع المنشور: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: W.B. Saunders Co Country of Publication: United States NLM ID: 9112938 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-8503 (Electronic) Linking ISSN: 10512276 NLM ISO Abbreviation: J Ren Nutr Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Philadelphia, PA : W.B. Saunders Co., [1991-
مواضيع طبية MeSH: Probiotics/*administration & dosage , Renal Insufficiency, Chronic/*therapy, Adult ; Bifidobacterium ; Biomarkers/blood ; Blood Glucose/metabolism ; Body Mass Index ; C-Reactive Protein/metabolism ; Cresols/blood ; Double-Blind Method ; Feces/chemistry ; Feces/microbiology ; Female ; Gastrointestinal Microbiome ; Humans ; Hydrogen-Ion Concentration ; Indican/blood ; Indoleacetic Acids/blood ; Interleukin-6/blood ; Lactobacillus acidophilus ; Male ; Middle Aged ; Nutrition Assessment ; Renal Insufficiency, Chronic/microbiology ; Streptococcus thermophilus ; Sulfuric Acid Esters/blood ; Waist Circumference
مستخلص: Objective: The objective of the study was to evaluate the effects of probiotic supplementation on the gut microbiota profile and inflammatory markers in chronic kidney disease patients undergoing maintenance hemodialysis (HD).
Design and Methods: This was a randomized, double-blind, placebo-controlled study. Forty-six HD patients were assigned to receive 1 of 2 treatments: probiotic (n = 23; Streptococcus thermophilus, Lactobacillus acidophilus e Bifidobacterialongum, 90 billion colony-forming units per day) or placebo (n = 23) daily for 3 months. Blood and feces were collected at baseline and after intervention. The inflammatory markers (C-reactive protein and interleukin-6) were analyzed by immunoenzymatic assay (enzyme-linked immunosorbent assay). Uremic toxins plasma levels (indoxyl sulfate, p-cresyl sulfate, and indole-3-acetic acid) were obtained by Reversed-Phase High-Performance Liquid Chromatography. Routine laboratory parameters were measured by standard techniques. Fecal pH was measured by the colorimetric method, and the gut microbiota profile was assessed by Denaturing Gradient Gel Electrophoresis analysis.
Results: Sixteen patients remained in the probiotic group (11 men, 53.6 ± 11.0 year old, 25.3 ± 4.6 kg/m 2 ) and 17 in the placebo group (10 men, 50.3 ± 8.5 year old, 25.2 ± 5.7 kg/m 2 ). After probiotic supplementation there was a significant increase in serum urea (from 149.6 ± 34.2 mg/dL to 172.6 ± 45.0 mg/dL, P = .02), potassium (from 4.4 ± 0.4 mmol/L to 4.8 ± 0.4 mmol/L, P = .02), and indoxyl sulfate (from 31.2 ± 15.9 to 36.5 ± 15.0 mg/dL, P = .02). The fecal pH was reduced from 7.2 ± 0.8 to 6.5 ± 0.5 (P = .01). These parameters did not change significantly in placebo group. Changes in the percentage delta (Δ) between groups were exhibited with no statistical differences observed. The inflammatory markers and gut profile were not altered by supplementation.
Conclusions: Aprobiotic supplementation failed to reduce uremic toxins and inflammatory markers. Therefore, probiotic therapy should be chosen with caution in HD patients. Further studies addressing probiotic therapy in chronic kidney disease patients are needed.
(Copyright © 2017 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.)
التعليقات: Comment in: J Ren Nutr. 2018 Jan;28(1):1-3. (PMID: 29249294)
المشرفين على المادة: 0 (Biomarkers)
0 (Blood Glucose)
0 (Cresols)
0 (IL6 protein, human)
0 (Indoleacetic Acids)
0 (Interleukin-6)
0 (Sulfuric Acid Esters)
56M34ZQY1S (4-cresol sulfate)
6U1S09C61L (indoleacetic acid)
9007-41-4 (C-Reactive Protein)
N187WK1Y1J (Indican)
تواريخ الأحداث: Date Created: 20170911 Date Completed: 20180806 Latest Revision: 20190306
رمز التحديث: 20240628
DOI: 10.1053/j.jrn.2017.06.010
PMID: 28888762
قاعدة البيانات: MEDLINE
الوصف
تدمد:1532-8503
DOI:10.1053/j.jrn.2017.06.010