دورية أكاديمية
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Development, Physicochemical Characterization and In Vitro Anti-Inflammatory Activity of Solid Dispersions of α,β Amyrin Isolated from Protium Oilresin.

التفاصيل البيبلوغرافية
العنوان: Development, Physicochemical Characterization and In Vitro Anti-Inflammatory Activity of Solid Dispersions of α,β Amyrin Isolated from Protium Oilresin.
المؤلفون: da Silva Júnior WF; Pharmacy Department, Health Sciences Center, Universidade Federal do Rio Grande do Norte (UFRN), Natal 59012-570, Rio Grande do Norte (RN), Brazil. walterjuniornt@hotmail.com., Pinheiro JGO; Pharmacy Department, Health Sciences Center, Universidade Federal do Rio Grande do Norte (UFRN), Natal 59012-570, Rio Grande do Norte (RN), Brazil. jgopinheiro@gmail.com., de Menezes DLB; Pharmacy Department, Health Sciences Center, Universidade Federal do Rio Grande do Norte (UFRN), Natal 59012-570, Rio Grande do Norte (RN), Brazil. daniellelbmenezes@gmail.com., E Silva NES; Pharmacy Department, Health Sciences Center, Universidade Federal do Rio Grande do Norte (UFRN), Natal 59012-570, Rio Grande do Norte (RN), Brazil. natan.farmacia@gmail.com., de Almeida PDO; Department of Pharmacy, Laboratory of Biological Activity, Federal University of Amazonas, Manaus 69077-000, AM, Brazil. patt_danielle@hotmail.com., Lima ES; Department of Pharmacy, Laboratory of Biological Activity, Federal University of Amazonas, Manaus 69077-000, AM, Brazil. eslima@ufam.edu.br., da Veiga Júnior VF; Department of Chemistry, Institute of Exact Sciences, Federal University of Amazonas, Manaus 69077-000, AM, Brazil. valdir.veiga@gmail.com.; Military Institute of Engineering, Rio de Janeiro 22290-270, RJ, Brazil. valdir.veiga@gmail.com., de Azevedo EP; Graduate Program in Biotechnology, Laureate International Universities-UnP, Natal 59056-000, RN, Brazil. azevedoep@hotmail.com., de Lima ÁAN; Pharmacy Department, Health Sciences Center, Universidade Federal do Rio Grande do Norte (UFRN), Natal 59012-570, Rio Grande do Norte (RN), Brazil. adleyantonini@yahoo.com.br.
المصدر: Molecules (Basel, Switzerland) [Molecules] 2017 Sep 09; Vol. 22 (9). Date of Electronic Publication: 2017 Sep 09.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c1995-
مواضيع طبية MeSH: Anti-Inflammatory Agents, Non-Steroidal/*chemistry , Burseraceae/*chemistry , Lipopolysaccharides/*antagonists & inhibitors , Nitric Oxide/*antagonists & inhibitors , Oleanolic Acid/*analogs & derivatives, Anti-Inflammatory Agents, Non-Steroidal/isolation & purification ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Cell Line ; Cell Survival/drug effects ; Humans ; Hypromellose Derivatives/chemistry ; Inflammation ; Lipopolysaccharides/pharmacology ; Macrophages/cytology ; Macrophages/drug effects ; Macrophages/metabolism ; Nitric Oxide/biosynthesis ; Oleanolic Acid/chemistry ; Oleanolic Acid/isolation & purification ; Oleanolic Acid/pharmacology ; Plant Oils/chemistry ; Polyethylene Glycols/chemistry ; Povidone/chemistry ; Resins, Plant/chemistry ; Suspensions
مستخلص: α,β Amyrin (ABAM) is a natural mixture of pentacyclic triterpenes that has shown a variety of pharmacological properties, including anti-inflammatory effect. ABAM is isolated from Burseraceae oilresins, especially from the Protium species, which is commonly found in the Brazilian Amazon. This work aimed to develop solid dispersions (SD) of ABAM with the following hydrophilic polymers: polyvinylpyrrolidone (PVP-K30), polyethylene glycol (PEG-6000) and hydroxypropylmethylcellulose (HPMC). The SDs were prepared by physical mixture (PM), kneading (KND) and rotary evaporation (RE) methods. In order to verify any interaction between ABAM and the hydrophilic polymers, physicochemical characterization was performed by Fourier transform infrared (FTIR), scanning electron microscopy (SEM), powder X-ray diffraction (XRD), thermogravimetry (TG) and differential scanning calorimetry (DSC) analysis. Furthermore, an in vitro anti-inflammatory assay was performed with ABAM alone and as SDs with the hydrophilic polymers. The results from the characterization analysis show that the SDs were able to induce changes in the physicochemical properties of ABAM, which suggests interaction with the polymer matrix. In vitro anti-inflammatory assay showed that the SDs improved the anti-inflammatory activity of ABAM and showed no cytotoxicity. In conclusion, this study showed the potential use of SDs as an efficient tool for improving the stability and anti-inflammatory activity of ABAM without cytotoxicity.
Competing Interests: The authors declare no conflict of interest.
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فهرسة مساهمة: Keywords: anti-inflammatory activity; hydrophilic polymers; pentacyclic triterpenes; solid dispersions; α,β amyrin
المشرفين على المادة: 0 (Anti-Inflammatory Agents, Non-Steroidal)
0 (Lipopolysaccharides)
0 (Plant Oils)
0 (Resins, Plant)
0 (Suspensions)
30IQX730WE (Polyethylene Glycol 6000)
31C4KY9ESH (Nitric Oxide)
3NXW29V3WO (Hypromellose Derivatives)
3WJQ0SDW1A (Polyethylene Glycols)
6SMK8R7TGJ (Oleanolic Acid)
FZ989GH94E (Povidone)
KM8353IPSO (beta-amyrin)
تواريخ الأحداث: Date Created: 20170912 Date Completed: 20180515 Latest Revision: 20191210
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6151820
DOI: 10.3390/molecules22091512
PMID: 28891943
قاعدة البيانات: MEDLINE
الوصف
تدمد:1420-3049
DOI:10.3390/molecules22091512