دورية أكاديمية
أعرض في EDS

Personalized translational epilepsy research - Novel approaches and future perspectives: Part I: Clinical and network analysis approaches.

التفاصيل البيبلوغرافية
العنوان: Personalized translational epilepsy research - Novel approaches and future perspectives: Part I: Clinical and network analysis approaches.
المؤلفون: Rosenow F; Epilepsy Center Frankfurt Rhine-Main, Department of Neurology, Center of Neurology and Neurosurgery, Goethe University Frankfurt, 60528 Frankfurt, Germany; Epilepsy Center Marburg, Department of Neurology, Philipps-University Marburg, 35043 Marburg, Germany; Center for Personalized Translational Epilepsy Research (CePTER), 60528 Frankfurt, Germany(1). Electronic address: rosenow@med.uni-frankfurt.de., van Alphen N; Epilepsy Center Frankfurt Rhine-Main, Department of Neurology, Center of Neurology and Neurosurgery, Goethe University Frankfurt, 60528 Frankfurt, Germany; Center for Personalized Translational Epilepsy Research (CePTER), 60528 Frankfurt, Germany(1)., Becker A; Institute for Neuropathology, University Bonn, 53105 Bonn, Germany., Chiocchetti A; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Goethe University Frankfurt, 60528 Frankfurt, Germany; Center for Personalized Translational Epilepsy Research (CePTER), 60528 Frankfurt, Germany(1)., Deichmann R; Brain Imaging Center (BIC) Frankfurt, Department of Neurology, Center of Neurology and Neurosurgery, Goethe University Frankfurt, 60528 Frankfurt, Germany; Center for Personalized Translational Epilepsy Research (CePTER), 60528 Frankfurt, Germany(1)., Deller T; Institute of Clinical Neuroanatomy, Dr. Senckenberg Anatomy, Neuroscience Center, Goethe University Frankfurt, 60590 Frankfurt, Germany; Center for Personalized Translational Epilepsy Research (CePTER), 60528 Frankfurt, Germany(1)., Freiman T; Epilepsy Center Frankfurt Rhine-Main, Department of Neurology, Center of Neurology and Neurosurgery, Goethe University Frankfurt, 60528 Frankfurt, Germany; Center for Personalized Translational Epilepsy Research (CePTER), 60528 Frankfurt, Germany(1)., Freitag CM; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Goethe University Frankfurt, 60528 Frankfurt, Germany; Center for Personalized Translational Epilepsy Research (CePTER), 60528 Frankfurt, Germany(1)., Gehrig J; Emmy-Noether Group Kell, Department of Neurology, Center of Neurology and Neurosurgery, Goethe University Frankfurt, 60528 Frankfurt, Germany; Center for Personalized Translational Epilepsy Research (CePTER), 60528 Frankfurt, Germany(1)., Hermsen AM; Epilepsy Center Frankfurt Rhine-Main, Department of Neurology, Center of Neurology and Neurosurgery, Goethe University Frankfurt, 60528 Frankfurt, Germany; Center for Personalized Translational Epilepsy Research (CePTER), 60528 Frankfurt, Germany(1)., Jedlicka P; Institute of Clinical Neuroanatomy, Dr. Senckenberg Anatomy, Neuroscience Center, Goethe University Frankfurt, 60590 Frankfurt, Germany; Center for Personalized Translational Epilepsy Research (CePTER), 60528 Frankfurt, Germany(1)., Kell C; Emmy-Noether Group Kell, Department of Neurology, Center of Neurology and Neurosurgery, Goethe University Frankfurt, 60528 Frankfurt, Germany; Center for Personalized Translational Epilepsy Research (CePTER), 60528 Frankfurt, Germany(1)., Klein KM; Epilepsy Center Frankfurt Rhine-Main, Department of Neurology, Center of Neurology and Neurosurgery, Goethe University Frankfurt, 60528 Frankfurt, Germany; Epilepsy Center Marburg, Department of Neurology, Philipps-University Marburg, 35043 Marburg, Germany; Center for Personalized Translational Epilepsy Research (CePTER), 60528 Frankfurt, Germany(1)., Knake S; Epilepsy Center Marburg, Department of Neurology, Philipps-University Marburg, 35043 Marburg, Germany; Center for Personalized Translational Epilepsy Research (CePTER), 60528 Frankfurt, Germany(1)., Kullmann DM; Institute of Neurology, University College London (UCL), London WC1E 6BT, United Kingdom., Liebner S; Edinger-Institute Frankfurt, Neuroscience Center, Goethe University Frankfurt, 60590 Frankfurt, Germany; Center for Personalized Translational Epilepsy Research (CePTER), 60528 Frankfurt, Germany(1)., Norwood BA; Epilepsy Center Marburg, Department of Neurology, Philipps-University Marburg, 35043 Marburg, Germany., Omigie D; Max-Planck-Institute for Empirical Aesthetics, 60322 Frankfurt, Germany; Center for Personalized Translational Epilepsy Research (CePTER), 60528 Frankfurt, Germany(1)., Plate K; Edinger-Institute Frankfurt, Neuroscience Center, Goethe University Frankfurt, 60590 Frankfurt, Germany; Center for Personalized Translational Epilepsy Research (CePTER), 60528 Frankfurt, Germany(1)., Reif A; Department of Psychiatry, Psychosomatics and Psychotherapy, Goethe University Frankfurt, 60528 Frankfurt, Germany; Center for Personalized Translational Epilepsy Research (CePTER), 60528 Frankfurt, Germany(1)., Reif PS; Epilepsy Center Frankfurt Rhine-Main, Department of Neurology, Center of Neurology and Neurosurgery, Goethe University Frankfurt, 60528 Frankfurt, Germany; Center for Personalized Translational Epilepsy Research (CePTER), 60528 Frankfurt, Germany(1)., Reiss Y; Edinger-Institute Frankfurt, Neuroscience Center, Goethe University Frankfurt, 60590 Frankfurt, Germany; Center for Personalized Translational Epilepsy Research (CePTER), 60528 Frankfurt, Germany(1)., Roeper J; Institute of Neurophysiology, Neuroscience Center, Goethe-University Frankfurt, 60590 Frankfurt, Germany; Center for Personalized Translational Epilepsy Research (CePTER), 60528 Frankfurt, Germany(1)., Ronellenfitsch MW; Dr. Senckenberg Institute for Neurooncology, Center of Neurology and Neurosurgery, Goethe University Frankfurt, 60528 Frankfurt, Germany; Center for Personalized Translational Epilepsy Research (CePTER), 60528 Frankfurt, Germany(1)., Schorge S; Institute of Neurology, University College London (UCL), London WC1E 6BT, United Kingdom., Schratt G; Institute of Physiological Chemistry, Philipps-University Marburg, 35043 Marburg, Germany; Center for Personalized Translational Epilepsy Research (CePTER), 60528 Frankfurt, Germany(1)., Schwarzacher SW; Institute of Clinical Neuroanatomy, Dr. Senckenberg Anatomy, Neuroscience Center, Goethe University Frankfurt, 60590 Frankfurt, Germany; Center for Personalized Translational Epilepsy Research (CePTER), 60528 Frankfurt, Germany(1)., Steinbach JP; Dr. Senckenberg Institute for Neurooncology, Center of Neurology and Neurosurgery, Goethe University Frankfurt, 60528 Frankfurt, Germany; Center for Personalized Translational Epilepsy Research (CePTER), 60528 Frankfurt, Germany(1)., Strzelczyk A; Epilepsy Center Frankfurt Rhine-Main, Department of Neurology, Center of Neurology and Neurosurgery, Goethe University Frankfurt, 60528 Frankfurt, Germany; Epilepsy Center Marburg, Department of Neurology, Philipps-University Marburg, 35043 Marburg, Germany; Center for Personalized Translational Epilepsy Research (CePTER), 60528 Frankfurt, Germany(1)., Triesch J; Frankfurt Institute for Advanced Studies (FIAS), 60438 Frankfurt, Germany; Center for Personalized Translational Epilepsy Research (CePTER), 60528 Frankfurt, Germany(1)., Wagner M; Institute of Neuroradiology, Center of Neurology and Neurosurgery, Goethe University Frankfurt, 60528 Frankfurt, Germany; Center for Personalized Translational Epilepsy Research (CePTER), 60528 Frankfurt, Germany(1)., Walker MC; Institute of Neurology, University College London (UCL), London WC1E 6BT, United Kingdom., von Wegner F; Epilepsy Center Frankfurt Rhine-Main, Department of Neurology, Center of Neurology and Neurosurgery, Goethe University Frankfurt, 60528 Frankfurt, Germany; Center for Personalized Translational Epilepsy Research (CePTER), 60528 Frankfurt, Germany(1)., Bauer S; Epilepsy Center Frankfurt Rhine-Main, Department of Neurology, Center of Neurology and Neurosurgery, Goethe University Frankfurt, 60528 Frankfurt, Germany; Epilepsy Center Marburg, Department of Neurology, Philipps-University Marburg, 35043 Marburg, Germany; Center for Personalized Translational Epilepsy Research (CePTER), 60528 Frankfurt, Germany(1).
المصدر: Epilepsy & behavior : E&B [Epilepsy Behav] 2017 Nov; Vol. 76, pp. 13-18. Date of Electronic Publication: 2017 Sep 13.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 100892858 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-5069 (Electronic) Linking ISSN: 15255050 NLM ISO Abbreviation: Epilepsy Behav Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Diego, CA : Academic Press, c2000-
مواضيع طبية MeSH: Precision Medicine*/trends, Anticonvulsants/*therapeutic use , Epilepsy/*drug therapy , Epilepsy/*genetics, Blood-Brain Barrier ; Brain/pathology ; Brain Injuries/pathology ; Epigenomics ; Genetic Markers/genetics ; Genetic Variation ; Humans ; Translational Research, Biomedical ; Treatment Outcome
مستخلص: Despite the availability of more than 15 new "antiepileptic drugs", the proportion of patients with pharmacoresistant epilepsy has remained constant at about 20-30%. Furthermore, no disease-modifying treatments shown to prevent the development of epilepsy following an initial precipitating brain injury or to reverse established epilepsy have been identified to date. This is likely in part due to the polyetiologic nature of epilepsy, which in turn requires personalized medicine approaches. Recent advances in imaging, pathology, genetics and epigenetics have led to new pathophysiological concepts and the identification of monogenic causes of epilepsy. In the context of these advances, the First International Symposium on Personalized Translational Epilepsy Research (1st ISymPTER) was held in Frankfurt on September 8, 2016, to discuss novel approaches and future perspectives for personalized translational research. These included new developments and ideas in a range of experimental and clinical areas such as deep phenotyping, quantitative brain imaging, EEG/MEG-based analysis of network dysfunction, tissue-based translational studies, innate immunity mechanisms, microRNA as treatment targets, functional characterization of genetic variants in human cell models and rodent organotypic slice cultures, personalized treatment approaches for monogenic epilepsies, blood-brain barrier dysfunction, therapeutic focal tissue modification, computational modeling for target and biomarker identification, and cost analysis in (monogenic) disease and its treatment. This report on the meeting proceedings is aimed at stimulating much needed investments of time and resources in personalized translational epilepsy research. Part I includes the clinical phenotyping and diagnostic methods, EEG network-analysis, biomarkers, and personalized treatment approaches. In Part II, experimental and translational approaches will be discussed (Bauer et al., 2017) [1].
(Copyright © 2017 Elsevier Inc. All rights reserved.)
معلومات مُعتمدة: G0802158 United Kingdom MRC_ Medical Research Council; G116/147 United Kingdom MRC_ Medical Research Council; MR/L01095X/1 United Kingdom MRC_ Medical Research Council; 086882/Z/08/Z United Kingdom WT_ Wellcome Trust
فهرسة مساهمة: Keywords: Biomarkers; New treatment targets; Personalized medicine; Precision medicine; Treatment targets
المشرفين على المادة: 0 (Anticonvulsants)
0 (Genetic Markers)
تواريخ الأحداث: Date Created: 20170918 Date Completed: 20180509 Latest Revision: 20211204
رمز التحديث: 20221213
DOI: 10.1016/j.yebeh.2017.06.041
PMID: 28917501
قاعدة البيانات: MEDLINE
الوصف
تدمد:1525-5069
DOI:10.1016/j.yebeh.2017.06.041