دورية أكاديمية
Highly Pathogenic Avian Influenza A(H5N1) Viruses at the Animal-Human Interface in Vietnam, 2003-2010.
| العنوان: | Highly Pathogenic Avian Influenza A(H5N1) Viruses at the Animal-Human Interface in Vietnam, 2003-2010. |
|---|---|
| المؤلفون: | Creanga A; Influenza Division, Centers for Disease Control and Prevention.; Battelle Memorial Institute, Atlanta, Georgia., Hang NLK; National Institute of Hygiene and Epidemiology., Cuong VD; National Institute of Hygiene and Epidemiology., Nguyen HT; Influenza Division, Centers for Disease Control and Prevention., Phuong HVM; National Institute of Hygiene and Epidemiology., Thanh LT; National Institute of Hygiene and Epidemiology., Thach NC; National Institute of Hygiene and Epidemiology., Hien PT; National Institute of Hygiene and Epidemiology., Tung N; National Centre of Veterinary Diagnostics., Jang Y; Influenza Division, Centers for Disease Control and Prevention., Balish A; Influenza Division, Centers for Disease Control and Prevention., Dang NH; National Centre of Veterinary Diagnostics., Duong MT; National Centre of Veterinary Diagnostics., Huong NT; National Centre of Veterinary Diagnostics., Hoa DN; National Centre of Veterinary Diagnostics., Tho ND; National Centre of Veterinary Diagnostics., Klimov A; Influenza Division, Centers for Disease Control and Prevention., Kapella BK; Influenza Division, Centers for Disease Control and Prevention.; Influenza and Animal-Human Interface Program, Centers for Disease Control and Prevention, Hanoi, Vietnam., Gubareva L; Influenza Division, Centers for Disease Control and Prevention., Kile JC; Influenza Division, Centers for Disease Control and Prevention.; Influenza and Animal-Human Interface Program, Centers for Disease Control and Prevention, Hanoi, Vietnam., Hien NT; National Institute of Hygiene and Epidemiology., Mai LQ; National Institute of Hygiene and Epidemiology., Davis CT; Influenza Division, Centers for Disease Control and Prevention. |
| المصدر: | The Journal of infectious diseases [J Infect Dis] 2017 Sep 15; Vol. 216 (suppl_4), pp. S529-S538. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2011- : Oxford : Oxford University Press Original Publication: 1904-2010 : Chicago, IL : University of Chicago Press |
| مواضيع طبية MeSH: | Influenza A Virus, H5N1 Subtype/*isolation & purification , Influenza in Birds/*epidemiology , Influenza, Human/*epidemiology, Amino Acid Sequence ; Animals ; Drug Resistance, Multiple, Viral ; Genotype ; Genotyping Techniques ; Humans ; Influenza A Virus, H5N1 Subtype/genetics ; Influenza in Birds/drug therapy ; Influenza in Birds/transmission ; Influenza, Human/drug therapy ; Pandemics ; Phylogeny ; Poultry/virology ; RNA, Viral/genetics ; Sequence Analysis, RNA ; Spatio-Temporal Analysis ; Vietnam/epidemiology ; Viral Proteins/genetics |
| مستخلص: | Mutation and reassortment of highly pathogenic avian influenza A(H5N1) viruses at the animal-human interface remain a major concern for emergence of viruses with pandemic potential. To understand the relationship of H5N1 viruses circulating in poultry and those isolated from humans, comprehensive phylogenetic and molecular analyses of viruses collected from both hosts in Vietnam between 2003 and 2010 were performed. We examined the temporal and spatial distribution of human cases relative to H5N1 poultry outbreaks and characterized the genetic lineages and amino acid substitutions in each gene segment identified in humans relative to closely related viruses from avian hosts. Six hemagglutinin clades and 8 genotypes were identified in humans, all of which were initially identified in poultry. Several amino acid mutations throughout the genomes of viruses isolated from humans were identified, indicating the potential for poultry viruses infecting humans to rapidly acquire molecular markers associated with mammalian adaptation and antiviral resistance. (Published by Oxford University Press for the Infectious Diseases Society of America 2017. This work is written by (a) US Government employee(s) and is in the public domain in the US.) |
| فهرسة مساهمة: | Keywords: Orthomyxovirus; Vietnam; evolution; highly pathogenic avian influenza A(H5N1) virus; phylogenetics |
| المشرفين على المادة: | 0 (RNA, Viral) 0 (Viral Proteins) |
| تواريخ الأحداث: | Date Created: 20170922 Date Completed: 20170929 Latest Revision: 20190221 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1093/infdis/jix003 |
| PMID: | 28934457 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1537-6613 |
|---|---|
| DOI: | 10.1093/infdis/jix003 |