دورية أكاديمية
أعرض في EDS

Respiratory syncytial virus hospitalization in middle-aged and older adults.

التفاصيل البيبلوغرافية
العنوان: Respiratory syncytial virus hospitalization in middle-aged and older adults.
المؤلفون: Malosh RE; University of Michigan School of Public Health, Ann Arbor, MI, United States. Electronic address: rmalosh@umich.edu., Martin ET; University of Michigan School of Public Health, Ann Arbor, MI, United States. Electronic address: etmartin@umich.edu., Callear AP; University of Michigan School of Public Health, Ann Arbor, MI, United States., Petrie JG; University of Michigan School of Public Health, Ann Arbor, MI, United States., Lauring AS; University of Michigan Medical School, Ann Arbor, MI, United States., Lamerato L; Henry Ford Health System, Detroit, MI, United States., Fry AM; Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA, United States., Ferdinands J; Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA, United States., Flannery B; Henry Ford Health System, Detroit, MI, United States., Monto AS; University of Michigan School of Public Health, Ann Arbor, MI, United States.
المصدر: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology [J Clin Virol] 2017 Nov; Vol. 96, pp. 37-43. Date of Electronic Publication: 2017 Sep 07.
نوع المنشور: Journal Article; Research Support, U.S. Gov't, P.H.S.; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 9815671 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5967 (Electronic) Linking ISSN: 13866532 NLM ISO Abbreviation: J Clin Virol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam : Elsevier Science, c1998-
مواضيع طبية MeSH: Hospitalization*, Respiratory Syncytial Virus Infections/*epidemiology , Respiratory Syncytial Virus Infections/*pathology , Respiratory Syncytial Viruses/*isolation & purification, Adolescent ; Adult ; Aged ; Aged, 80 and over ; Female ; Hospitals ; Humans ; Male ; Michigan ; Middle Aged ; Prognosis ; Prospective Studies ; Treatment Outcome ; Young Adult
مستخلص: Background: The importance of Respiratory Syncytial Virus (RSV) is increasingly recognized in hospitalized adults, but mainly in those ≥ 65 years.
Objectives: We sought to describe the epidemiology and clinical severity of RSV compared to influenza in hospitalized adults ≥18 years.
Study Design: Adults hospitalized with acute respiratory illnesses (ARI) of ≤10days duration were prospectively enrolled from two Michigan hospitals during two influenza seasons. Collected specimens were tested for RSV and influenza by real-time, reverse transcription polymerase chain reaction (RT-PCR). Viral load and subtype were determined for RSV-positive specimens. We evaluated factors associated with RSV and outcomes of infection using multivariable logistic regression. RSV-positive patients were separately compared to two reference groups: RSV-negative and influenza-negative, and influenza-positive patients.
Results: RSV was detected in 84 (7%) of 1259 hospitalized individuals (55 RSV-B, 29 RSV-A). The highest prevalence was found in 50-64year olds (40/460; 8.7%); 98% of RSV cases in this age group had at least one chronic comorbidity. RSV detection was associated with obesity (OR: 1.71 95% CI: 0.99-3.06, p=0.03). Individuals with RSV were admitted to the hospital later in their illness and had a higher median Charlson comborbidity index (3 vs 2 p<0.001) compared to those with influenza. Clinical severity of RSV-associated hospitalizations was similar to influenza-associated hospitalizations.
Discussion: In this study we observed the highest frequency of RSV-associated hospitalizations among adult 50-64 years old; many of whom had chronic comorbidities. Our results suggest the potential benefit of including these individuals in future RSV vaccination strategies.
(Copyright © 2017 Elsevier B.V. All rights reserved.)
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معلومات مُعتمدة: U01 IP000474 United States IP NCIRD CDC HHS; U01 IP000974 United States IP NCIRD CDC HHS; U01IP000974 United States ACL HHS; U01IP000974 ACL HHS
فهرسة مساهمة: Keywords: Adults*; Hospitalization*; Influenza*; RSV*; acute respiratory illness*
تواريخ الأحداث: Date Created: 20170925 Date Completed: 20180129 Latest Revision: 20191008
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC5889293
DOI: 10.1016/j.jcv.2017.09.001
PMID: 28942341
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-5967
DOI:10.1016/j.jcv.2017.09.001