دورية أكاديمية
Respiratory syncytial virus hospitalization in middle-aged and older adults.
العنوان: | Respiratory syncytial virus hospitalization in middle-aged and older adults. |
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المؤلفون: | Malosh RE; University of Michigan School of Public Health, Ann Arbor, MI, United States. Electronic address: rmalosh@umich.edu., Martin ET; University of Michigan School of Public Health, Ann Arbor, MI, United States. Electronic address: etmartin@umich.edu., Callear AP; University of Michigan School of Public Health, Ann Arbor, MI, United States., Petrie JG; University of Michigan School of Public Health, Ann Arbor, MI, United States., Lauring AS; University of Michigan Medical School, Ann Arbor, MI, United States., Lamerato L; Henry Ford Health System, Detroit, MI, United States., Fry AM; Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA, United States., Ferdinands J; Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA, United States., Flannery B; Henry Ford Health System, Detroit, MI, United States., Monto AS; University of Michigan School of Public Health, Ann Arbor, MI, United States. |
المصدر: | Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology [J Clin Virol] 2017 Nov; Vol. 96, pp. 37-43. Date of Electronic Publication: 2017 Sep 07. |
نوع المنشور: | Journal Article; Research Support, U.S. Gov't, P.H.S.; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 9815671 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5967 (Electronic) Linking ISSN: 13866532 NLM ISO Abbreviation: J Clin Virol Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier Science, c1998- |
مواضيع طبية MeSH: | Hospitalization*, Respiratory Syncytial Virus Infections/*epidemiology , Respiratory Syncytial Virus Infections/*pathology , Respiratory Syncytial Viruses/*isolation & purification, Adolescent ; Adult ; Aged ; Aged, 80 and over ; Female ; Hospitals ; Humans ; Male ; Michigan ; Middle Aged ; Prognosis ; Prospective Studies ; Treatment Outcome ; Young Adult |
مستخلص: | Background: The importance of Respiratory Syncytial Virus (RSV) is increasingly recognized in hospitalized adults, but mainly in those ≥ 65 years. Objectives: We sought to describe the epidemiology and clinical severity of RSV compared to influenza in hospitalized adults ≥18 years. Study Design: Adults hospitalized with acute respiratory illnesses (ARI) of ≤10days duration were prospectively enrolled from two Michigan hospitals during two influenza seasons. Collected specimens were tested for RSV and influenza by real-time, reverse transcription polymerase chain reaction (RT-PCR). Viral load and subtype were determined for RSV-positive specimens. We evaluated factors associated with RSV and outcomes of infection using multivariable logistic regression. RSV-positive patients were separately compared to two reference groups: RSV-negative and influenza-negative, and influenza-positive patients. Results: RSV was detected in 84 (7%) of 1259 hospitalized individuals (55 RSV-B, 29 RSV-A). The highest prevalence was found in 50-64year olds (40/460; 8.7%); 98% of RSV cases in this age group had at least one chronic comorbidity. RSV detection was associated with obesity (OR: 1.71 95% CI: 0.99-3.06, p=0.03). Individuals with RSV were admitted to the hospital later in their illness and had a higher median Charlson comborbidity index (3 vs 2 p<0.001) compared to those with influenza. Clinical severity of RSV-associated hospitalizations was similar to influenza-associated hospitalizations. Discussion: In this study we observed the highest frequency of RSV-associated hospitalizations among adult 50-64 years old; many of whom had chronic comorbidities. Our results suggest the potential benefit of including these individuals in future RSV vaccination strategies. (Copyright © 2017 Elsevier B.V. All rights reserved.) |
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معلومات مُعتمدة: | U01 IP000474 United States IP NCIRD CDC HHS; U01 IP000974 United States IP NCIRD CDC HHS; U01IP000974 United States ACL HHS; U01IP000974 ACL HHS |
فهرسة مساهمة: | Keywords: Adults*; Hospitalization*; Influenza*; RSV*; acute respiratory illness* |
تواريخ الأحداث: | Date Created: 20170925 Date Completed: 20180129 Latest Revision: 20191008 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC5889293 |
DOI: | 10.1016/j.jcv.2017.09.001 |
PMID: | 28942341 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1873-5967 |
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DOI: | 10.1016/j.jcv.2017.09.001 |