دورية أكاديمية
Small molecule targeting of PTPs in cancer.
| العنوان: | Small molecule targeting of PTPs in cancer. |
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| المؤلفون: | Lazo JS; Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, United States. Electronic address: lazo@virginia.edu., McQueeney KE; Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, United States., Burnett JC; Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, United States., Wipf P; Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, United States., Sharlow ER; Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, United States. |
| المصدر: | The international journal of biochemistry & cell biology [Int J Biochem Cell Biol] 2018 Mar; Vol. 96, pp. 171-181. Date of Electronic Publication: 2017 Sep 21. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9508482 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5875 (Electronic) Linking ISSN: 13572725 NLM ISO Abbreviation: Int J Biochem Cell Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: Exeter, England ; Tarrytown, NY, U.S.A. : Pergamon, c1995- |
| مواضيع طبية MeSH: | Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/therapeutic use , Neoplasms*/drug therapy , Neoplasms*/enzymology , Neoplasms*/genetics , Protein Tyrosine Phosphatases*/antagonists & inhibitors , Protein Tyrosine Phosphatases*/genetics , Protein Tyrosine Phosphatases*/metabolism, Drug Delivery Systems/*methods, Animals ; Humans |
| مستخلص: | Protein tyrosine phosphatases (PTPs) undeniably have a central role in the development and progression of human cancers. Historically, however, PTPs have not been viewed as privileged drug targets, and progress on identifying potent, selective, and cell-active small molecule PTP inhibitors has suffered accordingly. This situation is rapidly changing, however, due to biochemical advances in the study of PTPs and recent small molecule screening campaigns, which have identified potent and mechanistically diverse lead structures. These compounds are facilitating the exploration of the fundamental cellular processes controlled by PTPs in cancers, and could form the inflection point for new therapeutic paradigms for the treatment of a range of cancers. Herein, we review recent advances in the discovery and biological annotation of cancer-relevant small molecule PTP inhibitors. (Copyright © 2017. Published by Elsevier Ltd.) |
| معلومات مُعتمدة: | R21 CA191944 United States CA NCI NIH HHS; F31 CA196062 United States CA NCI NIH HHS |
| فهرسة مساهمة: | Keywords: Allosteric inhibition; Cancer; Chemical probes; Drug-like inhibitors; Tyrosine phosphatases |
| المشرفين على المادة: | 0 (Enzyme Inhibitors) EC 3.1.3.48 (Protein Tyrosine Phosphatases) |
| تواريخ الأحداث: | Date Created: 20170926 Date Completed: 20190103 Latest Revision: 20220317 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.biocel.2017.09.011 |
| PMID: | 28943273 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1878-5875 |
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| DOI: | 10.1016/j.biocel.2017.09.011 |