دورية أكاديمية
[Optimize concentrate process of alkaloid from Leonurus japonicus by ultrafultration-nanofiltration coupling technology].
| العنوان: | [Optimize concentrate process of alkaloid from Leonurus japonicus by ultrafultration-nanofiltration coupling technology]. |
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| المؤلفون: | Li CY; College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.; Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing 210023, China., Ma Y; College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China., Liu YZ; College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China., Li HY; College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China., Gu JM; College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China., Peng GP; College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.; Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing 210023, China. |
| المصدر: | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica [Zhongguo Zhong Yao Za Zhi] 2017 Jan; Vol. 42 (1), pp. 100-106. |
| نوع المنشور: | Journal Article |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Zhongguo yao xue hui : Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo Country of Publication: China NLM ID: 8913656 Publication Model: Print Cited Medium: Print ISSN: 1001-5302 (Print) Linking ISSN: 10015302 NLM ISO Abbreviation: Zhongguo Zhong Yao Za Zhi Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Beijing : Zhongguo yao xue hui : Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo Original Publication: [Beijing] : Zhongguo yao xue hui : [Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo, 1989- |
| مواضيع طبية MeSH: | Ultrafiltration*, Alkaloids/*isolation & purification , Leonurus/*chemistry, Drugs, Chinese Herbal ; Medicine, Chinese Traditional |
| مستخلص: | To optimize the concentrate process of alkaloid from Leonurus japonicus by nanofiltration-ultrafiltration coupling technology with response surface methodology. The experiment showed that after ultrafiltration pre-treatment, the total protein removal rate was 94.38% in aqueous extract from L. japonicus, and the nanofiltration technology had obvious advantages over the conventional concentrate process. The optimal concentrate conditions were as follows：molecular weight cut-off 450, pH 3.07, concentration of stachydrine hydrochloride 80.15 mg•L⁻¹, and concentration of the total alkaloid 285.73 mg•L⁻¹. The cut-off rate was 93.37% and 95.85% respectively for stachydrine hydrochloride and the total alkaloid under the optimum conditions, with a relative error of 0.79% and 1.16% respectively. The combination of Box-Behnken design and response surface analysis can well optimize the concentrate process of L. japonicus by nanofiltration, and the results provide the basis for nanofiltration concentrate for heat-sensitive traditional Chinese medicine. Competing Interests: The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose. (Copyright© by the Chinese Pharmaceutical Association.) |
| فهرسة مساهمة: | Keywords: Leonurus japonicas; alkaloid; concentrate; nanofiltration; stachydrine hydrochloride; ultrafiltration |
| المشرفين على المادة: | 0 (Alkaloids) 0 (Drugs, Chinese Herbal) |
| تواريخ الأحداث: | Date Created: 20170926 Date Completed: 20180531 Latest Revision: 20181202 |
| رمز التحديث: | 20240628 |
| DOI: | 10.19540/j.cnki.cjcmm.20161222.057 |
| PMID: | 28945032 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1001-5302 |
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| DOI: | 10.19540/j.cnki.cjcmm.20161222.057 |