دورية أكاديمية
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Developmental change and sexual difference in synaptic modulation produced by oxytocin in rat substantia gelatinosa neurons.

التفاصيل البيبلوغرافية
العنوان: Developmental change and sexual difference in synaptic modulation produced by oxytocin in rat substantia gelatinosa neurons.
المؤلفون: Jiang CY; Department of Physiology, Saga Medical School, 5-1-1 Nabeshima, Saga 849-8501, Japan., Fujita T; Department of Physiology, Saga Medical School, 5-1-1 Nabeshima, Saga 849-8501, Japan., Kumamoto E; Department of Physiology, Saga Medical School, 5-1-1 Nabeshima, Saga 849-8501, Japan.
المصدر: Biochemistry and biophysics reports [Biochem Biophys Rep] 2016 Jun 15; Vol. 7, pp. 206-213. Date of Electronic Publication: 2016 Jun 15 (Print Publication: 2016).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101660999 Publication Model: eCollection Cited Medium: Print ISSN: 2405-5808 (Print) Linking ISSN: 24055808 NLM ISO Abbreviation: Biochem Biophys Rep Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Amsterdam] : Elsevier B.V., [2015]-
مستخلص: We have previously reported that oxytocin produces an inward current at a holding potential of -70 mV without a change in glutamatergic excitatory transmission in adult male rat spinal lamina II (substantia gelatinosa; SG) neurons that play a pivotal role in regulating nociceptive transmission. Oxytocin also enhanced GABAergic and glycinergic spontaneous inhibitory transmissions in a manner sensitive to a voltage-gated Na + -channel blocker tetrodotoxin. These actions were mediated by oxytocin-receptor activation. Such a result was different from that obtained by other investigators in young male rat superficial dorsal horn neurons in which an oxytocin-receptor agonist enhanced glutamatergic and GABAergic but not glycinergic spontaneous transmissions. In order to know a developmental change and also sexual difference in the actions of oxytocin, we examined its effect on spontaneous synaptic transmission in adult female and young male rat SG neurons by using the whole-cell patch-clamp technique in spinal cord slices. In adult female rats, oxytocin produced an inward current at -70 mV without a change in excitatory transmission. GABAergic and glycinergic transmissions were enhanced by oxytocin, the duration of which enhancement was much shorter than in adult male rats. In young (11-21 postnatal days) male rats, oxytocin produced not only an inward but also outward current at -70 mV, and presynaptically inhibited or facilitated excitatory transmission, depending on the neurons tested; both GABAergic and glycinergic transmissions were enhanced by oxytocin. The inhibitory transmission enhancements in adult female and young male rats were sensitive to tetrodotoxin. Although the data may not be enough to be estimated, it is suggested that synaptic modulation by oxytocin in SG neurons, i.e. , cellular mechanism for its antinociceptive action, exhibits a developmental change and sexual difference.
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فهرسة مساهمة: Keywords: Developmental change; Excitatory transmission; Inhibitory transmission; Oxytocin; PND, postnatal day; SG, substantia gelatinosa; Sexual difference; Spinal substantia gelatinosa; TGOT, [Thr4, Gly7]-oxytocin; TTX, tetrodotoxin; VH, holding potential; sEPSC, spontaneous excitatory postsynaptic current; sIPSC, spontaneous inhibitory postsynaptic current
تواريخ الأحداث: Date Created: 20170929 Latest Revision: 20200930
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC5613344
DOI: 10.1016/j.bbrep.2016.06.011
PMID: 28955908
قاعدة البيانات: MEDLINE
الوصف
تدمد:2405-5808
DOI:10.1016/j.bbrep.2016.06.011