دورية أكاديمية
أعرض في EDS

Nuclear DNA as Predictor of Acute Kidney Injury in Patients Undergoing Coronary Artery Bypass Graft: A Pilot Study.

التفاصيل البيبلوغرافية
العنوان: Nuclear DNA as Predictor of Acute Kidney Injury in Patients Undergoing Coronary Artery Bypass Graft: A Pilot Study.
المؤلفون: Likhvantsev VV; Moscow Regional Clinical and Research Institute, Moscow, Russia., Landoni G; Anesthesiology and Intensive Care IRCCS San Raffaele Scientific Institute, Milan, Italy and Vita-Salute San Raffaele University, Milan, Italy. Electronic address: landoni.giovanni@hsr.it., Grebenchikov OA; Moscow Regional Clinical and Research Institute, Moscow, Russia., Skripkin YV; Moscow Regional Clinical and Research Institute, Moscow, Russia., Zabelina TS; Anesthesiology and Intensive Care Department, Moscow Regional Clinical and Research Institute, Moscow, Russia., Zinovkina LA; Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, Russia., Prikhodko AS; Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, Russia., Lomivorotov VV; Department of Anesthesiology and Intensive Care, State Research Institute of Circulation Pathology, Novosibirsk, Russia., Zinovkin RA; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.
المصدر: Journal of cardiothoracic and vascular anesthesia [J Cardiothorac Vasc Anesth] 2017 Dec; Vol. 31 (6), pp. 2080-2085. Date of Electronic Publication: 2017 May 01.
نوع المنشور: Journal Article; Observational Study
اللغة: English
بيانات الدورية: Publisher: W.B. Saunders Country of Publication: United States NLM ID: 9110208 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-8422 (Electronic) Linking ISSN: 10530770 NLM ISO Abbreviation: J Cardiothorac Vasc Anesth Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Philadelphia, PA : W.B. Saunders, c1991-
مواضيع طبية MeSH: Acute Kidney Injury/*blood , Acute Kidney Injury/*diagnosis , Coronary Artery Bypass/*adverse effects , DNA/*blood , Postoperative Complications/*blood , Postoperative Complications/*diagnosis, Acute Kidney Injury/etiology ; Aged ; Coronary Artery Bypass/trends ; Humans ; Middle Aged ; Pilot Projects ; Postoperative Complications/etiology ; Predictive Value of Tests ; Prospective Studies ; Risk Factors
مستخلص: Objective: To measure the release of plasma nuclear deoxyribonucleic acid (DNA) and to assess the relationship between nuclear DNA level and acute kidney injury occurrence in patients undergoing cardiac surgery.
Setting: Cardiovascular anesthesiology and intensive care unit of a large tertiary-care university hospital.
Design: Prospective observational study.
Participants: Fifty adult patients undergoing cardiac surgery.
Interventions: Nuclear DNA concentration was measured in the plasma. The relationship between the level of nuclear DNA and the incidence of acute kidney injury after coronary artery bypass grafting was investigated.
Measurements and Main Results: Cardiac surgery leads to significant increase in plasma nuclear DNA with peak levels 12 hours after surgery (median [interquartile range] 7.0 [9.6-22.5] µg/mL). No difference was observed between off-pump and on-pump surgical techniques. Nuclear DNA was the only predictor of acute kidney injury between baseline and early postoperative risk factors.
Conclusions: The authors found an increase of nuclear DNA in the plasma of patients who had undergone coronary artery bypass grafting, with a peak after 12 hours and an association of nuclear DNA with postoperative acute kidney injury.
(Copyright © 2017 Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: acute kidney injury; coronary artery bypass grafting; nuclear DNA; systemic inflammatory response syndrome
المشرفين على المادة: 9007-49-2 (DNA)
تواريخ الأحداث: Date Created: 20171003 Date Completed: 20180719 Latest Revision: 20180719
رمز التحديث: 20240628
DOI: 10.1053/j.jvca.2017.04.051
PMID: 28967626
قاعدة البيانات: MEDLINE
الوصف
تدمد:1532-8422
DOI:10.1053/j.jvca.2017.04.051