دورية أكاديمية
Design, Synthesis, and Characterization of N-Oxide-Containing Heterocycles with in Vivo Sterilizing Antitubercular Activity.
العنوان: | Design, Synthesis, and Characterization of N-Oxide-Containing Heterocycles with in Vivo Sterilizing Antitubercular Activity. |
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المؤلفون: | Dos Santos Fernandes GF; São Paulo State University (UNESP) , Institute of Chemistry, Araraquara 14800060, Brazil.; São Paulo State University (UNESP) , School of Pharmaceutical Sciences, Araraquara 14800903, Brazil.; Universidad de Navarra , Department of Organic and Pharmaceutical Chemistry, Instituto de Salud Tropical, Pamplona 31008, Spain., de Souza PC; São Paulo State University (UNESP) , School of Pharmaceutical Sciences, Araraquara 14800903, Brazil.; Institute of Tuberculosis Research, University of Illinois at Chicago , Chicago, Illinois 60607, United States., Moreno-Viguri E; Universidad de Navarra , Department of Organic and Pharmaceutical Chemistry, Instituto de Salud Tropical, Pamplona 31008, Spain., Santivañez-Veliz M; Universidad de Navarra , Department of Organic and Pharmaceutical Chemistry, Instituto de Salud Tropical, Pamplona 31008, Spain., Paucar R; Universidad de Navarra , Department of Organic and Pharmaceutical Chemistry, Instituto de Salud Tropical, Pamplona 31008, Spain., Pérez-Silanes S; Universidad de Navarra , Department of Organic and Pharmaceutical Chemistry, Instituto de Salud Tropical, Pamplona 31008, Spain., Chegaev K; Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino , Turin 10124, Italy., Guglielmo S; Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino , Turin 10124, Italy., Lazzarato L; Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino , Turin 10124, Italy., Fruttero R; Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino , Turin 10124, Italy., Man Chin C; São Paulo State University (UNESP) , School of Pharmaceutical Sciences, Araraquara 14800903, Brazil., da Silva PB; São Paulo State University (UNESP) , School of Pharmaceutical Sciences, Araraquara 14800903, Brazil., Chorilli M; São Paulo State University (UNESP) , School of Pharmaceutical Sciences, Araraquara 14800903, Brazil., Solcia MC; São Paulo State University (UNESP) , School of Pharmaceutical Sciences, Araraquara 14800903, Brazil., Ribeiro CM; São Paulo State University (UNESP) , School of Pharmaceutical Sciences, Araraquara 14800903, Brazil., Silva CSP; São Paulo State University (UNESP) , School of Pharmaceutical Sciences, Araraquara 14800903, Brazil., Marino LB; São Paulo State University (UNESP) , School of Pharmaceutical Sciences, Araraquara 14800903, Brazil., Bosquesi PL; São Paulo State University (UNESP) , School of Pharmaceutical Sciences, Araraquara 14800903, Brazil., Hunt DM; Mycobacterial Metabolism and Antibiotic Research Laboratory, The Francis Crick Institute , 1 Midland Road, London NW1 1AT, United Kingdom., de Carvalho LPS; Mycobacterial Metabolism and Antibiotic Research Laboratory, The Francis Crick Institute , 1 Midland Road, London NW1 1AT, United Kingdom., de Souza Costa CA; São Paulo State University (UNESP) , School of Odontology, Araraquara 14801903, Brazil., Cho SH; Institute of Tuberculosis Research, University of Illinois at Chicago , Chicago, Illinois 60607, United States., Wang Y; Institute of Tuberculosis Research, University of Illinois at Chicago , Chicago, Illinois 60607, United States., Franzblau SG; Institute of Tuberculosis Research, University of Illinois at Chicago , Chicago, Illinois 60607, United States., Pavan FR; São Paulo State University (UNESP) , School of Pharmaceutical Sciences, Araraquara 14800903, Brazil., Dos Santos JL; São Paulo State University (UNESP) , Institute of Chemistry, Araraquara 14800060, Brazil.; São Paulo State University (UNESP) , School of Pharmaceutical Sciences, Araraquara 14800903, Brazil. |
المصدر: | Journal of medicinal chemistry [J Med Chem] 2017 Oct 26; Vol. 60 (20), pp. 8647-8660. Date of Electronic Publication: 2017 Oct 16. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
اللغة: | English |
بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Washington Dc : American Chemical Society Original Publication: [Easton, Pa.] : American Chemical Society, [c1963- |
مواضيع طبية MeSH: | Antitubercular Agents/*chemistry , Antitubercular Agents/*pharmacology , Heterocyclic Compounds/*chemistry , Heterocyclic Compounds/*pharmacology, Animals ; Antitubercular Agents/chemical synthesis ; Antitubercular Agents/pharmacokinetics ; Biological Availability ; Caco-2 Cells ; Heterocyclic Compounds/chemical synthesis ; Heterocyclic Compounds/pharmacokinetics ; Humans ; Mice ; Mice, Inbred BALB C ; Microbial Sensitivity Tests ; Mycobacterium tuberculosis/drug effects ; Oxides/chemistry ; Spectrum Analysis/methods |
مستخلص: | Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), is the infectious disease responsible for the highest number of deaths worldwide. Herein, 22 new N-oxide-containing compounds were synthesized followed by in vitro and in vivo evaluation of their antitubercular potential against Mtb. Compound 8 was found to be the most promising compound, with MIC |
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معلومات مُعتمدة: | HHSN272201100009I United States AI NIAID NIH HHS; FC001060 United Kingdom CRUK_ Cancer Research UK; HHSN272201100009C United States AI NIAID NIH HHS; United Kingdom WT_ Wellcome Trust; FC001060 United Kingdom MRC_ Medical Research Council; FC001060 United Kingdom WT_ Wellcome Trust |
المشرفين على المادة: | 0 (Antitubercular Agents) 0 (Heterocyclic Compounds) 0 (Oxides) |
تواريخ الأحداث: | Date Created: 20171003 Date Completed: 20171121 Latest Revision: 20220129 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC5677254 |
DOI: | 10.1021/acs.jmedchem.7b01332 |
PMID: | 28968083 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1520-4804 |
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DOI: | 10.1021/acs.jmedchem.7b01332 |