دورية أكاديمية
Herbal Mixture Adsorbed to Polyethylene Glycol Microspheres Induces Apoptotic Effects on Breast Cancer Cells.
| العنوان: | Herbal Mixture Adsorbed to Polyethylene Glycol Microspheres Induces Apoptotic Effects on Breast Cancer Cells. |
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| المؤلفون: | Ribeiro AAL; Institute of Biological and Health Science, Federal University of Mato Grosso, Barra do Garcas, Mato Grosso, Brazil., da Silva FH; Institute of Biological and Health Science, Federal University of Mato Grosso, Barra do Garcas, Mato Grosso, Brazil., de Melo Cotrim AC; Institute of Biological and Health Science, Federal University of Mato Grosso, Barra do Garcas, Mato Grosso, Brazil., Deluque AL; Institute of Biological and Health Science, Federal University of Mato Grosso, Barra do Garcas, Mato Grosso, Brazil., de Marchi PGF; Institute of Biological and Health Science, Federal University of Mato Grosso, Barra do Garcas, Mato Grosso, Brazil., Fagundes DLG; Institute of Biological and Health Science, Federal University of Mato Grosso, Barra do Garcas, Mato Grosso, Brazil., de Sousa Pereira C; Institute of Biological and Health Science, Federal University of Mato Grosso, Barra do Garcas, Mato Grosso, Brazil., Franca EL; Institute of Biological and Health Science, Federal University of Mato Grosso, Barra do Garcas, Mato Grosso, Brazil., Honorio-Franca AC; Institute of Biological and Health Science, Federal University of Mato Grosso, Barra do Garcas, Mato Grosso, Brazil. |
| المصدر: | Current drug delivery [Curr Drug Deliv] 2018 Feb 14; Vol. 15 (2), pp. 227-234. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 101208455 Publication Model: Print Cited Medium: Internet ISSN: 1875-5704 (Electronic) Linking ISSN: 15672018 NLM ISO Abbreviation: Curr Drug Deliv Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Saif Zone, Sharjah, U.A.E. ; San Francisco, CA : Bentham Science Publishers, c2004- |
| مواضيع طبية MeSH: | Apoptosis/*drug effects , Breast Neoplasms/*drug therapy , Drugs, Chinese Herbal/*chemistry , Drugs, Chinese Herbal/*pharmacology , Polyethylene Glycols/*chemistry, Adolescent ; Adsorption ; Adult ; Breast Neoplasms/metabolism ; Calcium/metabolism ; Cell Line, Tumor ; Coculture Techniques/methods ; Female ; Humans ; Leukocytes, Mononuclear/drug effects ; Leukocytes, Mononuclear/metabolism ; MCF-7 Cells ; Male ; Microspheres ; Young Adult |
| مستخلص: | Background: The combination of medicinal plants and polymeric matrices raised the possibility of obtaining new drugs to treat a number of diseases, including cancer. Breast cancer is one of the most frequent diseases among women, but the effective treatments is still a challenge. Methods: Thus, this study investigated the effect of herbal mixture adsorbed to PEG microspheres on MCF-7 human breast cancer cells and these cells in co-culture of blood MN cells. The MCF-7 cells and the blood mononuclear [MN] cells from volunteer donors. MN cells, MCF-7 cells and co-culture [MN and MCF-7 cells] were pre-incubated for 24 h with or without herbal mixture [HM], polyethylene glycol [PEG] microspheres or herbal mixture adsorbed in PEG microspheres [PEG-HM]. Viability, intracellular calcium and apoptosis were determined by flow cytometry. The herbal mixture adsorbed in PEG microspheres reduces the viability of MCF-7 cells. Results: The lowest viability índex was observed in co-culture incubated with herbal mixture adsorbed to PEG microspheres. MN cells, MCF-7 cells and co-culture showed higher intracellular Ca2+ release when incubated with herbal mixture adsorbed to PEG microspheres. The apoptosis index was higher in MCF-7 cells that were treated with herbal mixture. The highest apoptosis index was observed in coculture of these cells incubated with herbal mixture adsorbed to PEG microspheres. Conclusion: These data suggest that herbal mixture adsorbed by PEG microspheres has apoptotic effects on human MCF-7 breast cancer cells and is therefore a possible therapeutic alternative. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.) |
| فهرسة مساهمة: | Keywords: MCF-7; MN cells; PEG Microspheres; apoptosis; cancer.; herbal mixture |
| المشرفين على المادة: | 0 (Drugs, Chinese Herbal) 3WJQ0SDW1A (Polyethylene Glycols) SY7Q814VUP (Calcium) |
| تواريخ الأحداث: | Date Created: 20171004 Date Completed: 20180829 Latest Revision: 20181202 |
| رمز التحديث: | 20221213 |
| DOI: | 10.2174/1567201814666171002141430 |
| PMID: | 28969566 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1875-5704 |
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| DOI: | 10.2174/1567201814666171002141430 |